A5002735508- Neonatal Health and Biochemistry
- Methemoglobinemia and Tumor Lysis Syndrome
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Respiratory Health Research
- Metabolism and Genetic Disorders
- Retinopathy of Prematurity Studies
- Hemoglobinopathies and Related Disorders
- Birth, Development, and Health
- Folate and B Vitamins Research
- Pharmaceutical studies and practices
- Pediatric Hepatobiliary Diseases and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Biomedical Research and Pathophysiology
- Antioxidant Activity and Oxidative Stress
- Retinal Diseases and Treatments
- Hemoglobin structure and function
- Blood Coagulation and Thrombosis Mechanisms
- Retinoids in leukemia and cellular processes
- Smoking Behavior and Cessation
- Connective tissue disorders research
- Pregnancy and preeclampsia studies
- Neonatal and Maternal Infections
- Porphyrin Metabolism and Disorders
University of North Carolina at Chapel Hill
2023-2024
University of Pennsylvania
1998-2007
Pennsylvania Hospital
1996-2006
Hospital of the University of Pennsylvania
1985-2006
University of Pennsylvania Health System
1999-2006
Wright State University
2002
Shimadzu (Japan)
1999
University of Wisconsin–Madison
1999
Northside Hospital
1999
Jefferson College
1996
Objective. To assess the predictive ability of a universal predischarge serum bilirubin measurement to screen for risk subsequent significant hyperbilirubinemia in direct Coombs negative healthy term and near-term newborn during first postnatal week. Methods. Total (TSB) levels were obtained at time routine metabolic all newborns cared Pennsylvania Hospital Well Baby Nursery (n = 13 003). Postnatal age (in hours) TSB was recorded. A percentile-based nomogram week constructed from...
Background. Jaundice in near-term and term newborns is a frequent diagnosis that may prompt hospital readmission the first postnatal week. Hyperbilirubinemia, when excessive, can lead to potentially irreversible bilirubin-induced neurotoxicity. Predischarge risk assessment (at 24–72 hours of age) for subsequent excessive hyperbilirubinemia feasible by laboratory-based assay total serum bilirubin (TSB). Hypothesis. Noninvasive, transcutaneous, point-of-care measurement transcutaneous (TcB)...
Objective. The purpose of this study was to determine whether end-tidal carbon monoxide (CO) corrected for ambient CO (ETCOc), as a single measurement or in combination with serum total bilirubin (STB) measurements, can predict the development hyperbilirubinemia during first 7 days life. Methods. From 9 multinational clinical sites, 1370 neonates completed cohort from February 20, 1998, through 22, 1999. Measurements both ETCOc and STB were performed at 30 ± 6 hours life; also measured 96 12...
Abstract Objective To investigate the potential value of ultrasound examination fetal profile for present/hypoplastic nasal bone at 15–22 weeks' gestation as a marker trisomy 21. Methods This was an observational study in 1046 singleton pregnancies undergoing amniocentesis karyotyping (median, 17) gestation. Immediately before examined to determine if present or hypoplastic (absent shorter than 2.5 mm). The incidence hypoplasia 21 and chromosomally normal fetuses determined likelihood ratio...
The incidence of culture-proven neonatal sepsis and necrotizing enterocolitis (NEC) in preterm infants maintained at pharmacologic (mean 5.1 mg/dL ± 1.45 SD) serum vitamin E levels for long periods was prospectively studied as part a double-masked clinical trial the effect prophylactic v placebo treatment on development course retinopathy prematurity (ROP). Within few days birth, 914 were enrolled study; 545 (275 placebo-treated infants, 270 E-treated had birth weight 1,500 g or less. A...
Conjugated and unconjugated bilirubin were injected intravenously at different times into normal rats homozygous, jaundiced Gunn rats. As was expected, did not excrete in the bile. After intravenous injection of conjugated rats, approximately twice as much appeared bile per 100 g body wt within 10 min than after comparable amounts bilirubin. This difference probably reflects time required for cellular uptake conjugation prior to excretion. The maximal biliary excretory rate following...
This paper describes the occurrence of kernicterus and factors which influence its development in strain rats * first studied by Gunn.<sup>22,23</sup>The disease humans designated 1903 Schmorl<sup>39</sup>as has, our opinion, not been observed or induced entirety animals. Various workers, however, have demonstrated toxicity indirect bilirubin.<sup>12-15,24,26,44-46</sup>Ernster, Herlin, Zetterström<sup>21</sup>have caused localized pigmentation brain rabbit treatment with bilirubin an S-H...
The clinicopathological syndrome of kernicterus observed in rats with congenital hypoglucuronyltransferasia (Gunn's strain rats) is similar to the human kernicterus. earliest detectable changes ganglion cells are associated presence intracellular bilirubin. Sulfonamides, do not produce normal newborn rats, nor they alter blood-brain barrier. Their deleterious effect Gunn's and premature infants may be explained by displacement bilirubin from blood compartment into extracellular fluid. It...
Journal Article Bilirubin Encephalopathy in the Gunn Rat: A Fine Structure Study of Cerebellar Cortex Get access Henry S. Schutta, M.D., M.D. Philadelphia, Pa. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lois Johnson, Neuropathology & Experimental Neurology, Volume 26, Issue 3, July 1967, Pages 377–396, https://doi.org/10.1097/00005072-196707000-00003 Published: 01 1967
In previous papers, 20,5,55 we have described the occurrence of kernicterus in Gunn strain rats, as well some factors which influence its incidence and pathogenesis. This paper concludes our current study rats summarizes approximately 2 years observation. Methods Terminology As jaundice gene is designated by small letter j normal capital J . 55 Kernicterus defined previously abbreviated tables KI. The methods for serum bilirubin (S.B.) sulfonamide determinations been described. Sodium p...
Journal Article Mitochondrial Abnormalities in Bilirubin Encephalopathy Get access Henry S. Schutta, M.D., M.D. Philadelphia, Pa. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lois Johnson, H. E. Neville, ‡Present Address: University of Colorado Medical Center, Denver, Colorado. Neuropathology & Experimental Neurology, Volume 29, Issue 2, April 1970, Pages 296–305, https://doi.org/10.1097/00005072-197004000-00010 Published: 01 1970
Factors believed to have contributed the reemergence of kernicterus in United States during 1990's are discussed: these include decreased concern about toxicity bilirubin term and near-term infants, increased prevalence breastfeeding, increasingly shortened postnatal hospital stays. The rationale for a universal predischarge measurement at time routine metabolic screen is presented: hour-specific level discharge, plotted on an Hour-Specific Bilirubin Nomogram, improves prediction risk...