A5003071685- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Marine animal studies overview
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Primate Behavior and Ecology
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Music and Audio Processing
- Virology and Viral Diseases
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Fungal Infections and Studies
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Neuroscience and Music Perception
- Bat Biology and Ecology Studies
- T-cell and B-cell Immunology
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- Chemotherapy-induced cardiotoxicity and mitigation
- CNS Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2016-2025
Roger Williams Medical Center
2015-2023
Providence College
2015-2023
Allen Institute for Brain Science
2022-2023
HealthPartners
2020
Boston University
2016-2018
Duke University
2005-2015
Office of Infectious Diseases
2015
Duke University Hospital
2010-2013
Birds display advanced behaviors, including vocal learning and problem-solving, yet lack a layered neocortex, structure associated with complex behavior in mammals. To determine whether these behavioral similarities result from shared or distinct neural circuits, we used single-cell RNA sequencing to characterize the neuronal repertoire of songbird song motor pathway. Glutamatergic neurons had considerable transcriptional similarity neocortical projection neurons; however, they displayed...
Songbirds learn to sing by memorizing a tutor song that they then vocally mimic using auditory feedback. This developmental sequence suggests brain areas encode memories communicate with for learned vocal control. In the songbird, secondary telencephalic region caudal mesopallium (CM) contains neurons aspects of experience. We investigated whether CM is an important source input two sensorimotor structures implicated in singing, nucleus interface (NIf) and HVC. used reversible inactivation...
Following a serogroup B meningococcal disease outbreak at an Oregon university, carriage evaluation was conducted in conjunction with MenB-FHbp and MenB-4C vaccination campaign. Neither vaccine associated reduced among participants.
Birdsong, like human speech, is a series of learned vocal gestures resulting from the coordination and respiratory brainstem networks under control telencephalon. The song motor circuit includes premotor cortical analogs, known as HVC (used proper name) RA (the robust nucleus arcopallium), respectively. Previous studies showed that projects to projection neurons (PNs) topographically innervate vocal-motor networks. idea singing-related activity flows between in strictly feedforward manner...
Animals learn many complex behaviors by emulating the behavior of more experienced individuals. This essential, yet still poorly understood, form learning relies on ability to encode lasting memories observed behaviors. We identified a vocal-motor pathway in zebra finch where that guide song-element durations can be implanted. Activation synapses this seeds duration and override from social interactions with other Genetic lesions circuit after memory formation, however, do not disrupt...
Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. The drug is commonly used prevent graft rejection in solid organ transplant and graft-versus-host disease hematopoietic stem cell patients. Tacrolimus has narrow therapeutic index with variable oral bioavailability metabolism via cytochrome P-450 3A enzyme. Toxicity can occur from overdosing or drug-drug interactions the simultaneous administration...
Abstract Disruption of the transcription factor FoxP2, which is enriched in basal ganglia, impairs vocal development humans and songbirds. The ganglia are important for selection sequencing motor actions, but circuit mechanisms governing accurate learned vocalizations unknown. Here, we show that expression FoxP2 vital fluent initiation termination birdsong, as well maintenance song syllable adulthood. Knockdown imbalances dopamine receptor across striatal direct-like indirect-like pathways,...
Neuronal activity during experience is thought to induce plastic changes within the hippocampal network that underlie memory formation, although extent and details of such in vivo remain unclear. Here, we employed a temporally precise marker neuronal activity, CaMPARI2, label active CA1 neurons vivo, followed by immediate acute slice preparation electrophysiological quantification synaptic properties. Recently superficial sublayer stratum pyramidale displayed larger post-synaptic responses...
Precise neural sequences are associated with the production of well-learned skilled behaviors. Yet, how arise in brain remains unclear. In songbirds, premotor projection neurons cortical song nucleus HVC necessary for producing learned and exhibit precise sequential activity during singing. Using cell-type specific calcium imaging we identify populations beginning ending singing-related sequences. We characterize that bookend neuronal transition from sparse preparatory prior to Recordings...
Disrupted expression of the autism gene, FoxP1, blocks ability young birds to form memories used learn their adult song.
Sensorimotor computations for learning and behavior rely on precise patterns of synaptic connectivity. Yet, we typically lack the wiring diagrams long-range connections between sensory motor circuits in brain. Here provide diagram sensorimotor involved production zebra finch song, a natural ethologically relevant behavior. We examined functional connectivity from 4 main afferent pathways onto 3 known classes projection neurons song premotor cortical region HVC. Recordings hundreds identified...
Sensorimotor computations for learning and behavior rely on precise patterns of synaptic connectivity. Yet, we typically lack the wiring diagrams long-range connections between sensory motor circuits in brain. Here provide diagram sensorimotor involved production zebra finch song, a natural ethologically relevant behavior. We examined functional connectivity from 4 main afferent pathways onto 3 known classes projection neurons song premotor cortical region HVC. Recordings hundreds identified...
The dorsal striatum is important for highly specialized functions including movement, learning, and habit formation. However, it not known if species-specialized behaviors are associated with cellular specializations in the striatum. Here, we compared single-nucleus RNA sequencing (snRNA-seq) data from human, chimpanzee, rhesus macaque, common marmoset, pale spear-nosed bat caudate (CN) putamen (Pu) separately as well mouse caudoputamen (C-Pu), which represents divergence among species...
Abstract How brain circuits are organized to skillfully produce learned sequences of behaviors is still poorly understood. Here, we functionally examine how the ‘cortical’ song premotor region HVC, which necessary for zebra finch song, controls sequential production syllables. We find that HVC can generate complete sequence syllables independently its main synaptic input pathways. Thalamic permissive initiation but it not required transitions between or completing song. show excitation...