A5034643470- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Sperm and Testicular Function
- Ovarian function and disorders
- Phytochemistry and Biological Activities
- Reproductive Biology and Fertility
- Multiple Sclerosis Research Studies
- Fungal Plant Pathogen Control
Max Delbrück Center
2021
University of Göttingen
2021
Fluorine (19F) magnetic resonance imaging (MRI) is severely limited by a low signal-to noise ratio (SNR), and tapping it for 19F drug detection in vivo still poses significant challenge. However, bears the potential label-free theranostic imaging. Recently, we detected fluorinated dihydroorotate dehydrogenase (DHODH) inhibitor teriflunomide (TF) noninvasively an animal model of multiple sclerosis (MS) using MR spectroscopy (MRS). In present study, probed distinct modifications to CF3 group...
Abstract Background: Embryos are usually produced in culture systems with an oil overlay, which conveys protection against the evaporation of water and microbial contamination. The can also release toxic substances absorb essential components, such as hormones, adversely affect quality oocytes development embryos vitro. Objective: aim this study was to validate oil‐free bovine vitro production (IVP) system. Method: Cumulus–oocyte complexes collected from abattoir‐derived ovaries were...
Purpose Low SNR in fluorine‐19 ( 19 F) MRI benefits from cryogenically‐cooled transceive surface RF probes (CRPs), but strong B 1 inhomogeneities hinder quantification. Rapid acquisition with refocused echoes (RARE) is an SNR‐efficient method for of neuroinflammation perfluorinated compounds lacks analytical signal intensity equation to retrospectively correct inhomogeneity. Here, a workflow was proposed and validated quantify F‐MR signals the inflamed mouse brain using F‐CRP. Methods In...
Siponimod is a fluorinated drug approved for treatment of secondary progressive multiple sclerosis. We detect 19 F-MR signal in the liver, brain, kidneys, and thymus, achieve first images disease modifying drug, both liver brain ex vivo proof-of-concept experiment. Clear concentration differences between lobes or regions CNS can be observed. have demonstrated feasibility using F-MRI to study distribution drugs improve our understanding pharmacokinetics guide therapeutic decisions.