A5022471358- Mesenchymal stem cell research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Immune Cell Function and Interaction
- Adolescent and Pediatric Healthcare
- Malaria Research and Control
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Bipolar Disorder and Treatment
- Transplantation: Methods and Outcomes
- Tryptophan and brain disorders
- Organ Transplantation Techniques and Outcomes
- Reproductive System and Pregnancy
- Renal Transplantation Outcomes and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- Pregnancy and preeclampsia studies
- Cancer Immunotherapy and Biomarkers
- Preterm Birth and Chorioamnionitis
- Hearing, Cochlea, Tinnitus, Genetics
Leiden University Medical Center
2017-2024
The Netherlands Cancer Institute
2021
Leiden University
2021
Peter Doherty Institute
2017
The University of Melbourne
2017
Although the immunological complexity of maternal-fetal interface is well appreciated, actual interaction maternal immune cells and fetal trophoblasts insufficiently understood. To comprehend composition spatial orientation extravillous trophoblasts, we applied imaging mass cytometry on decidua basalis three trimesters healthy pregnancy. Within all trimesters, observed considerably higher frequencies myeloid in than seen with single-cell suspension techniques. Moreover, they were most...
Abstract We describe an MHC class II (I-Ab)–restricted TCR transgenic mouse line that produces CD4+ T cells specific for Plasmodium species. This line, termed PbT-II, was derived from a cell hybridoma generated to blood-stage berghei ANKA (PbA). PbT-II responded all species and stages tested so far, including rodent (PbA, P. NK65, chabaudi AS, yoelii 17XNL) human (Plasmodium falciparum) parasites as well irradiated PbA sporozoites. can provide help generation of Ab infection control this...
Tacrolimus is the backbone of immunosuppressive agents to prevent transplant rejection. Paradoxically, tacrolimus nephrotoxic, causing irreversible tubulointerstitial damage. Therefore, infusion mesenchymal stromal cells (MSC) 6 and 7 weeks post-transplantation was assessed facilitate withdrawal in randomized phase II TRITON trial. Here, we performed detailed analysis peripheral blood immune composition using mass cytometry assess potential effects MSC therapy on system. We developed two...
Background. Kidney transplantation is the preferred treatment option for patients with end-stage renal disease. However, long-term graft survival remains a challenge. The enzyme indoleamine 2,3 dioxygenase (IDO) has been reported to have immunomodulatory effects IDO transcripts being elevated in both antibody-mediated rejection and T cell–mediated rejection. Methods. A metal-conjugated antibody panel staining of kidney biopsies was developed, allowing visualization 41 structural immune...
Stem-cell-based repair of auditory neurons may represent an attractive therapeutic option to restore sensorineural hearing loss. Hair-follicle-bulge-derived stem cells (HFBSCs) are promising candidates for this type therapy, because they (1) have migratory properties, enabling migration after transplantation, (2) can differentiate into sensory and glial cells, (3) easily be harvested in relatively high numbers. However, HFBSCs never been used purpose. We hypothesized that cell-based the...
Infusion of mesenchymal stromal cells (MSCs) has been proposed as immune-modulatory therapy in solid organ transplantation. The use allogenic MSCs could improve standardization and allow for direct availability the product.
Abstract We describe an MHC II (IA b )-restricted T cell receptor (TCR) transgenic mouse line that produces CD4 + cells specific for Plasmodium species. This line, termed PbT-II, was derived from a hybridoma generated to blood-stage berghei ANKA (PbA). PbT-II responded all species and stages tested so far, including rodent (PbA, P. NK65, chabaudi AS yoelii 17XNL) human ( P . falciparum) parasites as well irradiated PbA sporozoites. can provide help generation of antibody infection control...
While the immunological complexity of maternal-fetal interface is well appreciated, actual interaction maternal immune cells and fetal trophoblasts insufficiently understood. To comprehend composition spatial orientation extravillous trophoblasts, we applied imaging mass cytometry on decidua basalis three trimesters healthy pregnancy. Within all trimesters, observed considerably higher frequencies myeloid in than seen with single-cell suspension techniques. Moreover, they were most...