A5075463942- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Machine Learning in Bioinformatics
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
- Glutathione Transferases and Polymorphisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Congenital Diaphragmatic Hernia Studies
- Gene expression and cancer classification
- ATP Synthase and ATPases Research
- HVDC Systems and Fault Protection
- Protease and Inhibitor Mechanisms
- Sulfur Compounds in Biology
- Cancer-related gene regulation
- Neonatal Health and Biochemistry
Fujian Medical University
2021-2024
Union Hospital
2021-2024
Abstract Background Lung adenocarcinoma (LUAD) is a prevalent malignancy. SNHG15 has been demonstrated to be oncogenic in many kinds of cancers, however the mechanism LUAD cisplatin (DDP) resistance remains unclear. In this study, we effect on DDP and its related mechanism. Methods Bioinformatics analysis was adopted assess expression tissues predict downstream genes SNHG15. The binding relationship between regulatory proved through RNA immunoprecipitation, chromatin immunoprecipitation...
Cell division cycle 5-like (CDC5L) protein is implicated in the development of various cancers. However, its role progression lung adenocarcinoma (LUAD) remains uncertain. Our findings revealed frequent upregulation CDC5L LUAD, which correlated with poorer overall survival rates and advanced clinical stages.
Abstract METTL14 functions as an RNA methyltransferase involved in m6A modification, influencing mRNA biogenesis, decay, and translation processes. However, the specific mechanism by which regulates glucose-6-phosphate dehydrogenase (G6PD) to promote progression of lung adenocarcinoma (LUAD) is not well understood. Quantitative measurement immunohistochemistry (IHC) analysis have demonstrated higher levels LUAD tissues compared adjacent normal tissues. Additionally, expression was...
AbstractSerum miRNAs are available clinical samples for cancer screening. Identifying early serum markers in lung (LC) is essential patients' diagnosis and treatment. Expression data of adenocarcinoma (LUAD) patients healthy individuals were downloaded from the Gene Omnibus (GEO). These normalized subjected to differential expression analysis obtain differentially expressed (DEmiRNAs). The DEmiRNAs subsequently ReliefF feature selection, subsets closely related screened as candidate miRNAs....
Cisplatin resistance is common in non‑small cell lung cancer (NSCLC); however, the molecular mechanisms remain unclear. The present study aimed to identify a new function of Golgi phosphoprotein 3 (GOLPH3) NSCLC‑associated cisplatin resistance. Using A549 human NSCLC cells and cisplatin‑resistant variant, stable lines with GOLPH3 knockdown or overexpression were established using lentiviral vectors. Through Cell Counting Kit‑8 EdU assays, it was revealed that significantly enhanced...
Objective: The interaction between immunity and hypoxia in tumor microenvironment (TME) has clinical significance, this study aims to explore immune-hypoxia related biomarkers LUAD guide accurate prognosis of patients. Methods: gene expression dataset was downloaded from GEO TCGA databases. immune-related genes hypoxia-related were acquired ImmPort MSigDB databases, respectively. Genes immune obtained by intersection. significantly prognostic LASSO Cox regression analyses a model...
Idiopathic pulmonary fibrosis (IPF) is a progressive and life-threatening respiratory disease characterized by worsening lung function due to excessive scarring. The objective of this study was investigate the role long non-coding RNA ANRIL (antisense in INK4 locus) development IPF. Our research revealed significant increase expression fibrosis, consistent with prior studies indicating elevated levels fibrotic tissues. In vitro experiments demonstrated that promoted fibroblast activation, as...