A5047183615- RNA modifications and cancer
- Congenital heart defects research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Forensic and Genetic Research
- Cancer-related gene regulation
- Congenital Heart Disease Studies
- Insect Resistance and Genetics
- Signaling Pathways in Disease
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Viral Infectious Diseases and Gene Expression in Insects
- Coronary Artery Anomalies
- SARS-CoV-2 and COVID-19 Research
- 14-3-3 protein interactions
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Immunotoxicology and immune responses
- Birth, Development, and Health
- Crystallization and Solubility Studies
- Complement system in diseases
- Protein Kinase Regulation and GTPase Signaling
Fujian Medical University
2021-2024
Union Hospital
2021-2024
Immunomedics (Germany)
2024
Weatherford College
2024
Hunan Normal University
2012-2023
Soochow University
2018
East China Normal University
2016
Shenzhen University
2009
Objectives: This study aimed to evaluate the associations between bullying victimization and life satisfaction in primary school children also investigate interactive effects of left-behind status on satisfaction. Materials Methods: Bullying was measured using Chinese version revised Olweus Bully/Victim Questionnaire. Life assessed Multidimensional Students' Satisfaction Scale (MSLSS). is composed five domains, namely, family, school, friends, environment, self-satisfaction. Left-behind...
In this work, the solid–liquid equilibrium for levetiracetam in 10 neat solvents (methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, ethyl acetate, 1,4-dioxane, toluene, and cyclohexane) binary liquid mixtures (ethanol + acetate) was measured by using a static gravimetric method at temperatures T = 283.15–323.15 K under pressure of 101.2 kPa. general, solubility highest methanol lowest cyclohexane. The modified Apelblat equation, λh Wilson model, NRTL model were used to...
Lung adenocarcinoma (LUAD) is one of the common cancers. Studies show that MMP-1 involved in tumor progression, yet relevant regulatory mechanism LUAD remains to be further elucidated. Here, we demonstrated from bioinformatics analysis for GEO data was differentially up-regulated LUAD. miR-202-3p, identified as upstream regulator by both and dual-luciferase assays, down-regulated presented a negative correlation with MMP-1. Following cell biological experiments proved knocking down...
The sterile alpha motif (SAM) is a putative protein interaction domain involved in wide variety of biological processes. Here we report the identification and characterization novel gene, SAMD4B, which encodes 694 amino acids with SAM domain. Northern blot RT-PCR analysis showed that SAMD4B widely expressed human embryonic adult tissues. Transcriptional activity assays show suppresses transcriptional L8G5-luciferase. Over-expression mammalian cells inhibited activities activator protein-1...
Previous studies have demonstrated that Smyd1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization. In this study, we uncovered novel function of the regulation endothelial cells (ECs). Our data showed is expressed vascular cells, knockdown SMYD1 impairs EC migration tube formation. Furthermore, Co-IP GST pull-down assays associated with Serum Response Factor (SRF). EMSA further forms complex SRF enhances DNA binding activity. indicate...
Objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aimed to investigate the prevalence and factors hyperhomocysteinemia, especially modifiable lifestyle factors, such as smoking behaviour dietary factors. Design Population-based cross-sectional study. Setting Hunan Province, China Participants A total of 4012 participants completed study, between July 2013 March 2014. The median age 55 (interquartile range: 45–63) years, with 1644 males (41%) 2368...
Wnt/β-catenin signaling plays a key role in pathological cardiac remodeling adults. The identification of tissue-specific interaction factor may provide clinical targeting strategy. Drosophila Pygo encodes the core Wnt/β-catenin. Two homologs (Pygo1 and Pygo2) have been identified mammals. Different from ubiquitous expression profile Pygo2, Pygo1 is enriched tissue. However, mammalian disease yet to be elucidated. In this study, we found that was upregulated human tissues with hypertrophy....
Lung cancer is one of the most prevalent types worldwide, and non-small-cell lung (NSCLC) accounts for ~85% all cases. Despite notable prevalence NSCLC, mechanisms underlying its progression remain unclear. The present study investigated involvement FK506-binding protein 51 (FKBP51) in NSCLC development determined factors associated with FKBP51 modification treatment. Immunohistochemical analysis was performed to analyze expression human tissue samples. Additionally, flow cytometry observe...
Abstract The association between memory CD4+ T cells and cancer prognosis is increasingly recognized, but their impact on lung adenocarcinoma (LUAD) remains unclear. In this study, using the cell‐type identification by estimating relative subsets of RNA transcripts algorithm, we analyzed immune cell composition patient survival in LUAD. Weighted gene coexpression network analysis helped identify cell–associated modules. Combined with module genes, a five‐gene LUAD prognostic risk model (...
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory with limited therapeutic options. Pseudognaphalium affine (D. Don) Anderb. medicinal and edible plant used to treat cough, asthma, COPD for long time in folk medicine. The objective of this study evaluate the effect extract (GAE) investigate possible underlying mechanism vivo vitro. In vivo, administration GAE rat model could significantly ameliorate lung damage function by inhibiting production pro-inflammatory cytokines....
Background: Transforming growth factor-β (TGF-β)/nodal signaling is involved in early embryonic patterning vertebrates. Nodal modulator (Nomo, also called pM5) a negative regulator of nodal signaling. Currently, the role nomo gene cartilage development vertebrates remains unknown. Methods: Nomo mutants were generated knockout model zebrafish by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) targeting fibronectin type III domain....
Background: Short tandem repeats (STRs) are powerful genetic markers widely used in human genetics. Population data and locus-specific mutation rates of STRs crucial for the evaluation interpretation evidence forensic population genetics.Aim: To investigate 21 autosomal a from central south China.Subjects methods: This study analysed 3420 paternity cases with Combined Paternity Index >10,000 Han Hunan. A total 68,743 meiotic transfers were 62 mutations identified.Results: The overall rate...
Abstract BVES is a transmembrane protein, our previous work demonstrated that single nucleotide mutations of in tetralogy fallot (TOF) patients cause downregulation transcription. However, the relationship between and pathogenesis TOF has not been determined. Here we reported research results about right ventricular outflow tract (RVOT) stenosis. expression was significantly downregulated most samples compared with controls. The second heart field (SHF) regulatory network genes, including...
Background: Tetralogy of Fallot (TOF) accounts for ∼10% congenital heart disease cases. The blood vessel epicardial substance (BVES) gene has been reported to play a role in the function adult hearts. However, whether allelic variants BVES contribute risk TOF and its possible mechanism remains unknown. Methods: open reading frame was sequenced using samples from 146 patients 100 unrelated healthy controls. qRT-PCR western blot assays were used confirm expression mutated samples. online...
Immune checkpoint inhibitor pneumonitis (ICIP) is thought to be a self-limiting disease; however, an effective treatment option does not currently exist. This study aimed determine the clinical efficacy of combination therapy with glucocorticoids and pirfenidone for ICIP related programmed cell death protein-1 (PD-1) inhibitors. We conducted retrospective analysis 45 patients advanced non-small lung cancer who developed following PD-1 albumin-bound paclitaxel or carboplatin at our hospital....
Objective: The interaction between immunity and hypoxia in tumor microenvironment (TME) has clinical significance, this study aims to explore immune-hypoxia related biomarkers LUAD guide accurate prognosis of patients. Methods: gene expression dataset was downloaded from GEO TCGA databases. immune-related genes hypoxia-related were acquired ImmPort MSigDB databases, respectively. Genes immune obtained by intersection. significantly prognostic LASSO Cox regression analyses a model...
This study aimed to examine the impact of short-term adiposity change on risk high blood pressure (HBP), and assess low limit range body mass index (BMI) waist-to-height ratio (WHtR) reduction proposed decrease HBP in children. Children were longitudinally surveyed at baseline after a follow-up. General obesity (GOB) is categorized by age gender-specific BMI cut-off points, abdominal (AOB) WHtR. Logistic regression model was used estimate relations between with adjustment covariates. A total...