A5067133288- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Cerebrovascular and genetic disorders
- Acute Ischemic Stroke Management
- Bipolar Disorder and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Dialysis and Renal Disease Management
- Cardiovascular Health and Disease Prevention
- Health, Environment, Cognitive Aging
- Electroconvulsive Therapy Studies
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Mental Health Treatment and Access
University of Calgary
2015-2024
Population Health Research Institute
2021
Hamilton Health Sciences
2021
Ontario Brain Institute
2019
Neuropsychiatric symptoms (NPS) are risk factors for Alzheimer's disease (AD) but can also manifest secondary to AD pathology. Mild behavioral impairment (MBI) refers later-life emergent and persistent NPS that may mark early-stage AD. To distinguish MBI from transient or which represent psychiatric conditions (non-MBI NPS), we investigated the effect of applying criteria on associations with structural imaging biomarkers incident cognitive decline. Data participants (n = 1273) normal...
To determine whether cognitive reserve attenuates the association of vascular brain injury with cognition.Cross-sectional data were analyzed from 2 harmonized studies: Canadian Alliance for Healthy Hearts and Minds (CAHHM) Prospective Urban Rural Epidemiology (PURE) study. Markers education, involvement in social activities, marital status, height, leisure physical activity, which combined into a composite score. Vascular was defined as nonlacunar infarcts or high white matter hyperintensity...
Background: Cerebral amyloid angiopathy (CAA) is associated with cognitive decline. CAA has diverse impacts on brain structure and function; however, the lesions that mediate association of cognition are not understood well. Aims: To determine degree to which neuroimaging biomarkers dysfunction. Methods: We analyzed cross-sectional data patients probable controls without impairment from Functional Assessment Vascular Reactivity study. Neuropsychological tests were grouped into domains...
Background: Cognitive reserve may protect against the effects of brain pathology, but few studies have looked at whether cognitive modifies adverse vascular pathology. Objective: We determined if attenuates associations lesions with worse cognition in persons subjective concerns or mild impairment. Methods: analyzed 200 participants aged 50–90 years from Comprehensive Assessment Neurodegeneration and Dementia (COMPASS-ND) study. Cognition was measured using Montreal a neuropsychological test...
Abstract Background Mild behavioral impairment (MBI) refers to the de novo emergence of persistent neuropsychiatric symptoms in older adults and has been associated with cognitive decline incident dementia. The purpose this study was identify structural neural correlates MBI using a hypothesis‐driven region‐of‐interest (ROI) approach. Method cohort consisted 744 participants (60.3% female; mean SD age = 71.0 ± 9.7 years; education: 15.8 5.3 years) without dementia from National Alzheimer’s...
Limited research is available on children and adolescent psychosis. Thus, we conducted a Meta-Analysis of pharmaceutical treatments, using literature from the last 5 years. A 16 year cumulative prevalence psychosis in Calgary Health Region was also examined. Conduct to determine effective treatments for study Zone 1994-2009. Update identify treatment interventions psychosis, Region. Direct physician billing data used (Alberta) 1994-2009 (n = 763449) 73078 unique individuals (30762-males,...
Abstract Background Mild behavioral impairment (MBI) identifies a high‐risk group for Alzheimer’s disease and related dementias (ADRD), leveraging the risk associated with later‐life emergent persistent neuropsychiatric symptoms (NPS). MBI may act as complementary analog to cognitive (mild impairment, MCI). These constructs are not mutually exclusive can co‐occur. We characterized relationship between MBI, grey matter volume in hippocampus entorhinal cortex, incident decline older adults...