A5000992386- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- HIV/AIDS drug development and treatment
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Atmospheric and Environmental Gas Dynamics
- Biopolymer Synthesis and Applications
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- RNA and protein synthesis mechanisms
- Electrochemical sensors and biosensors
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- HIV Research and Treatment
- Lipid metabolism and disorders
- Head and Neck Anomalies
- Soil Carbon and Nitrogen Dynamics
- NF-κB Signaling Pathways
- Cancer Risks and Factors
- Biochemical and Molecular Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
Nanchang University
2022-2024
Third Hospital of Nanchang
2024
Weifang Medical University
2024
Heilongjiang Academy of Land Reclamation Sciences
2019-2023
First Affiliated Hospital of Zhengzhou University
2023
Fudan University
2017-2023
Weatherford College
2021-2023
Zhengzhou People's Hospital
2023
Yanbian University
2021-2023
Tongren Hospital
2021-2022
Abstract Purpose: The epidermal growth factor receptor (EGFR) overexpressed in approximately 80% of non-small cell lung cancers (NSCLC) is a target for novel therapeutics. Concurrent chemoradiation the current standard care treatment patients with locally advanced NSCLC. However, < 20% remain disease-free at 5 years despite this aggressive treatment. Cetuximab humanized monoclonal antibody that recognizes human EGFR, and previous studies, inhibited EGFR-expressing cancer lines. In...
Increasing evidence shows that long noncoding RNAs (lncRNAs) have important roles in the regulation of multiple cellular processes, including cell division, growth, and apoptosis, as well cancer metastasis neurological disease progression; however, mechanism how lncRNAs regulate these processes is not established. In this study, we demonstrated downregulating expression lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) breast cells inhibited growth induced apoptosis. addition,...
Significance Triple-negative breast cancer (TNBC) is responsible for significant mortality among subtypes, with its treatment largely unsuccessful due to ineffective targeted therapies. Our bioinformatics analysis demonstrates a unique alternative splicing pattern in TNBC compared those of other cancers. In analyzing the underlying mechanism distinct profile, TDP43 , critical gene previously implicated neurodegenerative disease, found promote progression. Mechanistically, regulates extensive...
Abstract TRAIL has been proposed as an anti-inflammatory cytokine in animal models of rheumatoid arthritis (RA). Using two agonistic mAbs specific for TRAIL-R1 (DR4) and TRAIL-R2 (DR5), we examined the expression function these death receptors RA synovial fibroblast cells. The tissues primary cells isolated from patients with RA, but not those osteoarthritis, selectively expressed high levels cell surface DR5 were highly susceptible to anti-DR5 Ab (TRA-8)-mediated apoptosis. In contrast,...
Nasopharyngeal carcinoma (NPC) is a common epithelial malignancy that occurs in the nasopharynx and it one of high incidences malignant tumors China. As previous reports, berberine hydrochloride (BH) possesses repressive effect on proliferation various cancer types. But application BH was hampered for long time due to its hydrophobic properties, along with poor stability bioavailability. In this study, folate acid modified chitosan nanoparticles loaded (BH/FA-CTS NPs) were prepared by ionic...
Abstract Alternative splicing (AS) is a promising clinical target for cancer treatment at the post-transcriptional level. We previously identified unique AS profile in triple-negative breast (TNBC), which regulated by regulator TAR DNA-binding protein-43 (TDP43), thus indicating crucial role of TDP43 heterogeneous TNBC. Cluster differentiation 44 (CD44), widely recognized marker stem cells (BCSCs), extensively spliced into CD44 variant isoforms (CD44v) during development cancer. At present,...
Abstract Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. However, underlying molecular mechanism less clear. Here we report that TDP-43, RNA-binding protein, underwent positive selection in mammalian lineage. Furthermore, TDP-43 gene ( Tardbp ) loss induces accumulation large droplets severe deficiency mammary epithelial cells outside alveolar lumens, eventually resulting lactation failure pup starvation within three weeks...
Atherosclerosis is the most common cause of cardiovascular diseases in world. Although development atherosclerosis appears to be result multiple maladaptive pathways, a particularly important factor pathogenesis oxidized low-density lipoprotein (ox-LDL), which contributes endothelial damage. Data from our laboratory and others show that follistatin-related protein (FRP), expressed vasculature, has cardioprotective effects, suggesting loss FRP protection might play role atherosclerosis. In...
MicroRNAs (miRNAs) play a key role in the regulation of gene expression. In this study, we aimed to identify clinical values miR-1179 and investigate potential molecular mechanisms breast cancer (BC).RT-PCR was used detect expression levels both BC tissues cell lines. We analyzed association between clinicopathological factors patient prognosis. The proliferation ability on cells assessed by MTT colony formation assay. migration invasion measured transwell assays. Western blot analysis...
Bone marrow niche cells have been reported to fine-tune hematopoietic stem cell (HSC) stemness via direct interaction or secreted components. Nevertheless, how control HSC activities remains largely unknown. We previously showed that angiopoietin-like protein 2 (ANGPTL2) can support the ex vivo expansion of HSCs by binding human leukocyte immunoglobulin-like receptor B2. However, ANGPTL2 from specific types regulates under physiological conditions is still not clear. Herein, we generated an...
Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1 (EC50 = 1.0 nmol/L), but the poor metabolic stability in human liver microsomes (t1/2 14.6 min) and insufficient selectivity (SI 2059) with high cytotoxicity (CC50 2.08 μmol/L) remained major issues associated JK-4b. The present efforts were devoted to introduction of fluorine into biphenyl ring JK-4b, leading discovery novel series fluorine-substituted...
Abstract. As China has approximately 22% of the world's rice paddies, regional quantification CH4 emissions from these paddies is important in determining their contribution to global greenhouse gas effect. This paper reports use a biogeochemical model (DeNitrification and DeComposition or DNDC) for quantifying fields Taihu Lake region China. For this application, DNDC was linked 1:50 000 soil database derived 1107 paddy profiles compiled during Second National Soil Survey 1980s–1990s. The...
Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66 (SI = 2019.80, S 1.9 μg/mL), a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility were identified by replacement the biphenyl moiety heterocyclic group lower lipophilicity. Evidently, representative analog 7w in this exhibited dramatically enhanced 12,497.73, 4472 μg/mL) comparison μg/mL). This new NNRTI conferred low nanomolar...
TGF-β signaling pathway inhibition is considered an effective way to prevent the development of several diseases. In design and synthesis inhibitors, a rhodanine compound containing quinoxalinyl imidazole moiety was found have strong antimicrobial activity.The purpose this work investigate activity other chiral inhibitors synthesized.Two series 3-substituted-5-(5-(6-methylpyridin-2-yl)-4-(quinoxalinyl-6-yl)- 1Himidazol- 2-yl)methylene)-2-thioxothiazolin-4-ones (12a-h 13a-e) were synthesized...