A5041799453- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Appendicitis Diagnosis and Management
- Gastrointestinal motility and disorders
- Diverticular Disease and Complications
- Biosimilars and Bioanalytical Methods
- Digestive system and related health
- Colorectal Cancer Screening and Detection
- Immunodeficiency and Autoimmune Disorders
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Stoma care and complications
- Diet and metabolism studies
- Celiac Disease Research and Management
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- IgG4-Related and Inflammatory Diseases
- T-cell and B-cell Immunology
- Nutrition, Genetics, and Disease
- Immune Cell Function and Interaction
Alfred Health
2017-2025
Monash University
2017-2025
The Alfred Hospital
2015-2024
The Royal Melbourne Hospital
2022
Response Biomedical (Canada)
2021
King's College London
2012-2019
Guy's and St Thomas' NHS Foundation Trust
2012-2019
St Thomas' Hospital
2011-2019
University Gastroenterology
2018
Central Clinical Hospital
2018
The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on patient's life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into role genetics in prognosis. We identify noncoding polymorphism FOXO3A (rs12212067: T > G) at which minor (G) allele, despite not being associated with susceptibility, milder...
ABSTRACT Background Advice to avoid dietary emulsifiers in Crohn's disease (CD) is based on preclinical data. Aims To examine the effect of diets high (HED) and low (LED) food supply activity CD. Methods In a double‐blinded, randomised feeding study, we adults with symptomatic, sonographically active CD ileal involvement ≥ 2 months' stable medical therapy 4 weeks HED or LED modelled Australian healthy eating guidelines. We measured Harvey‐Bradshaw Index (HBI), sonographic indices (IBUS‐SAS,...
<h3>Objective</h3> Crohn9s disease (CD) is associated with intestinal dysbiosis, altered blood T cell populations, elevated faecal calprotectin (FC) and increased permeability (IP). CD-associated features present in siblings (increased risk of CD) but not healthy controls, provide insight into early CD pathogenesis. We aimed to (1) Delineate the genetic, immune microbiological profile patients CD, their controls (2) Determine which factors discriminate between groups. <h3>Design</h3> Faecal...
Abstract Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the architecture of trait remains largely unknown. The recent development machine learning (ML) approaches incited us to apply them classify healthy and diseased people according their genomic information. Immunochip dataset containing 18,227 CD patients 34,050 controls enrolled genotyped by international Inflammatory Bowel...
We have tracked the fate of immature human B cells at a critical stage in their development when mature cell repertoire is shaped. show that major subset bone marrow emigrant cells, transitional 2 (T2) homes to gut-associated lymphoid tissue (GALT) and most T2 isolated from GALT are activated. Activation previously unknown potential for cells. The process maturation through naive includes removal autoreactive developing repertoire, which known fail systemic lupus erythematosus (SLE). observe...
Summary Background Intestinal ultrasound (IUS) is a valuable tool for assessment of Crohn’s disease (CD). However, there no widely accepted luminal activity index. Aims To identify appropriate IUS protocols, indices, items, and scoring methods measurement CD integration in clinical trials. Methods An expert international panel adult paediatric gastroenterologists (n = 15) radiologists 3) rated the appropriateness 120 statements derived from literature review opinion (scale 1‐9) using...
Summary Background Although dietary emulsifiers are implicated in the pathogenesis of Crohn's disease, their effect has not been studied humans. Aim To determine effects high‐ and low‐emulsifier diets (HED, LED) on intestinal barrier function healthy subjects unstressed acutely stressed states. Methods We conducted a single‐blinded, cross‐over, controlled feeding trial 22 adults. After recording 7 days habitual diet, we randomised participants to HED or LED with ≥3‐week washout between...
Background: The aims of this study were to develop and evaluate a high/low-emulsifier diet compare emulsifier content with preclinical studies that have associated Crohn’s disease emulsifiers. Methods: Supermarkets audited seven-day high- (HED) low-emulsifier (LED) meal plan developed. food was sought from manufacturers, compared acceptable daily intake (ADI), doses provided in trials. Nutritional composition analysis completed. Healthy adults ate these diets for seven days randomized...
The contribution of rare coding sequence variants to genetic susceptibility in complex disorders is an important but unresolved question. Most studies thus far have investigated a limited number genes from regions which contain common disease associated variants. Here we investigate this inflammatory bowel by sequencing the exons and proximal promoters 531 selected both genome-wide association pathway analysis pooled DNA panels 474 cases Crohn's 480 controls. 80 with evidence experiment or...
OBJECTIVES: Galacto-oligosaccharides (GOS) are dietary FODMAPs (fermentable carbohydrates) associated with triggering gastrointestinal symptoms in patients irritable bowel syndrome (IBS). This randomized, double-blind, placebo-controlled, cross-over trial aimed to assess whether oral α-galactosidase co-ingestion foods high GOS and low other would reduce symptoms. METHODS: Patients meeting the Rome III criteria for IBS who were hydrogen-producers on breath testing recruited. Participants...
Orofacial granulomatosis (OFG) causes chronic, disfiguring, granulomatous inflammation of the lips and oral mucosa. A proportion cases have co-existing intestinal Crohn's disease (CD). The pathogenesis is unknown but has recently been linked to dietary sensitivity. Although allergy suggested as an aetiological factor in OFG there are few published data support this link. In study, we sought clinical evidence a series patients with compared inflammatory bowel (IBD) without involvement...
Abstract Background Preclinical studies implicate dietary emulsifiers as detrimental to patients with Crohn’s disease. We aimed examine the effect of high- and low-emulsifiers diets on intestinal inflammation in adults ileal Methods In a pilot double-blinded, randomized, controlled feeding study, symptomatic sonographically active disease involvement stable medical therapy were randomized received four weeks an isocaloric high (HED) or low (LED) emulsifier diet modelled Australian healthy...
One goal of human genetics is to understand the genetic basis disease, a challenge for diseases complex inheritance because risk alleles are few relative vast set benign variants. Risk variants often sought by association studies in which allele frequencies case subjects contrasted with those from population-based samples used as control subjects. In an ideal world we would know population-level frequencies, releasing researchers focus on We argue this possible, at least theoretically, and...
To evaluate clinical outcomes, patterns of use, tolerance and nutritional outcomes exclusive enteral nutrition (EEN) in adults with Crohn's disease to compare initiation the inpatient compared ambulatory care setting.Adults who received EEN at a single centre over 2.5 years were identified assessed via examination patient records.EEN was initiated 60 patients (23 as an outpatient) had objective evidence active disease. Of 49 whom goal induction remission, 28 completed 24 achieved...
Background The syndrome of constipation with other abdominal symptoms (“proximal constipation”) in ulcerative colitis (UC) is commonly recognized by practitioners but poorly described, no definition and little understanding regard to prevalence effect therapies on disease outcomes. This study aimed address these issues a cross‐sectional, consecutive series patients UC. Methods A working proximal was established. Consecutive were recruited, their activity, recent medications, investigations...