A5100440283- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Coronary Interventions and Diagnostics
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Orthodontics and Dentofacial Orthopedics
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- Dental Radiography and Imaging
- Atherosclerosis and Cardiovascular Diseases
- Dental Anxiety and Anesthesia Techniques
- Infectious Diseases and Mycology
- Natural product bioactivities and synthesis
- Mycobacterium research and diagnosis
- NF-κB Signaling Pathways
- Ferroptosis and cancer prognosis
Harbin Medical University
2022
Second Affiliated Hospital of Harbin Medical University
2022
Weifang People's Hospital
2021
Beijing Chang'an Integrated Traditional Chinese and Western Medicine Hospital
2021
Huazhong University of Science and Technology
2021
Central Hospital of Wuhan
2021
Aerospace Center Hospital
2021
Henan University Huaihe Hospital and Huaihe Clinical Institute
2020
Jinan Maternity And Care Hospital
2020
Chinese People's Liberation Army
2012
Lung cancer is the most frequent cause of cancer-related mortality in men, and 85 % lung diagnosed as non-small-cell (NSCLC). Plasmacytoma variant translocation1 (PVT1) serves an oncogenic factor NSCLC. However, pathogenesis PVT1 NSCLC still vague. The expression levels PVT1, sex determining region Y (SRY)-related high mobility group (HMG)-box9 (SOX9), microRNA (miR)-361-3p tissues cells were detected by quantitative real-time polymerase chain reaction (RT-qPCR). protein SOX9, β-catenin,...
The long noncoding RNAs (lncRNAs) have been confirmed to be involved in sepsis-induced organ injury. Here, we first investigated the functional role and underlying mechanism of lncRNA LINC00472 acute hepatic injury (AHI). Human liver THLE-3 cells were treated with lipopolysaccharide (LPS) mimic AHI vitro; intraperitoneal injection LPS rats used as an vivo model induced by sepsis. expressions LINC00472, miR-373-3p, TRIM8 mRNA detected qRT-PCR. effects miR-373-3p on viability assessed CCK-8...
Objective . To explore the effect and related mechanism of LncRNA PVT1 on hypoxia‐induced cardiomyocyte injury. Methods PVT1RNA miR‐214‐3p levels were detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). Cell vitality apoptosis were, respectively, evaluated Counting Kit‐8 (CCK‐8) flow cytometry analysis. Starbase Dual luciferase reporter (DLR) gene assay was employed to validate interaction between PVT1. Results statistically upregulated, downregulated in H9c2 cells. The...
To investigate the association between operation time and serious postoperative symptom severity (PoSS) in patients following surgical removal of mandibular third molar (M3M), independent degree impaction.A retrospective hospital-based observational study was carried out at Stomatology Hospital Tianjin Medical University. The recorded divided by quartiles (Q1-Q4). primary outcome PoSS. Clinical, demographic radiologic variables were also recorded. A descriptive bivariate analysis performed....
Myasthenia gravis (MG) is a T cell-dependent antibody-mediated autoimmune disorder that can seriously affect patients' quality of life. However, few studies have focused on the severity MG. Moreover, existing therapeutic efforts, including those targeting biomarkers for MG, remain unsatisfactory. Therefore, it vital we investigate pathogenesis MG and identify new not only evaluate disease but also serve as potential targets. Long noncoding RNA LINC00680 has been found to be associated with...
Abstract Background: Ferroptosis is a newly described form of regulated cell death, targeting nuclear factor erythroid-2-related 2 (Nrf2) -mediated ferroptosis may be an attractive option to counteract malignant tumor. Whether miR-144-5p sensitize erastin-induced in gastric cancer via regulation Nrf2 pathway unclear. Methods: To speculate the function cancers, bioinformatic analysis was performed. Dual-luciferase reporter gene assay used predict effect on expression Nrf2. The expressions and...
The occurrence of vascular endothelial injury is key to the progression atherosclerosis (AS). This research explores expression lncRNA DLGAP1-AS1 in a mouse model and its effect on ox-LDL-induced cell injury. A AS was constructed, detected using nano real-time PCR method. Vascular cells (VEC) are categorized into four groups. Flow cytometry detects apoptosis, Western blot Bax Bcl-2 expressions; WST-8 method level SOD. Thiobarbituric acid method, Ammonium molybdate colorimetric DCFH-DA were...