A5113222206- Histiocytic Disorders and Treatments
- Genetic and rare skin diseases.
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- Vascular Malformations and Hemangiomas
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA regulation and disease
- Mast cells and histamine
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Multiple Myeloma Research and Treatments
- Hedgehog Signaling Pathway Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Acute Myeloid Leukemia Research
- Cardiac Imaging and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Genital Health and Disease
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Spine and Intervertebral Disc Pathology
- Knee injuries and reconstruction techniques
Peking Union Medical College Hospital
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Henan Institute of Geological Survey
2025
Second Affiliated Hospital of Jilin University
2024
The First People's Hospital of Shunde
2023
Ningxia Medical University General Hospital
2021-2022
Ningxia Medical University
2017-2022
Academy of Medical Sciences
2015-2020
Union Hospital
2009
Huazhong University of Science and Technology
2009
Background Myocardial injury (MI) was a severe complication of novel coronavirus disease (COVID-19) and inflammation suggested as potential cause for MI. However, the correlation MI with in COVID-19 patients is not revealed so far. Method This retrospective single-center cohort study enrolled 64 critically ill COVID-19. Patients were categorized into two groups by presence on admission. Demographic data, clinical characteristics, laboratory tests, treatments outcomes analyzed this study....
Not available.
To evaluate the heart response of Erdheim-Chester disease (ECD) through continuous follow-up within our large cohort, for which there is a lack understanding.
Summary The optimal treatment strategy for adult Langerhans cell histiocytosis (LCH) remains unclear. Our previous study demonstrated the remarkable efficacy of combined methotrexate and cytarabine (Ara‐C) [MA] therapy in patients newly diagnosed with LCH, a median follow‐up 2 years. present article reports long‐term data spanning 78 months (6.5 years) from single‐arm, single‐centre, prospective phase clinical trial (NCT 02389400) conducted between January 2014 December 2020. Ninety‐five...
<div>AbstractPurpose:<p>Langerhans cell histiocytosis (LCH) is a rare and highly heterogeneous histiocytosis. There are currently few studies examining the correlation between molecular profiling clinical phenotype or outcomes in adult patients with LCH. The objective of this study was to characterize genomic landscape LCH correlate findings features patient outcomes.</p>Experimental Design:<p>This included 254 patients, ages ≥18 years, biopsy-proven from January 2000...
<p>Supplementary Figure S4. The function complex (BRAF-MEK-14-3-3) predicted by Alphafold3 [PyMOL(TM) 2.5.3 - Incentive Product Copyright (C) Schrodinger, LLC.].</p>
<p>Supplementary Figure S2. Initial treatments of adult patients with LCH.</p>
<p>Supplementary Figure S3. Prognosis of adult patients with LCH according to BRAFV600E status.</p>
<p>Supplementary Figure S1. The distribution of myeloid-associated mutations based on age at diagnosis. relationship between and diagnosis.</p>
<p>Supplementary Video S1. The function complex (BRAF-MEK-14-3-3) predicted by Alphafold3.</p>
Idiopathic multicentric Castleman disease (iMCD) is a rare characterized by polyclonal lymphoproliferation and systemic inflammation. Siltuximab, targeting interleukin-6 (IL-6), has been recommended as the first-line therapy for iMCD. However, substantial real-world data from China were still lacking, treatment patients with severe iMCD remained challenging. This single-center retrospective study investigated efficacy safety of siltuximab-based in 43 consecutive July 2022 to March 2024. The...
Comprehensive assessment of pore structure and multiphase water distribution is critical to the flow transport process in coalbed methane (CBM) reservoirs. In this study, nuclear magnetic resonance (NMR) multifractal analysis were integrated quantify multiscale heterogeneity nine medium- high-rank coals under water-saturated dry conditions. By applying box-counting method transverse relaxation time (T2) spectra, parameters derived characterize residual distribution. The influencing factors...
Although pegylated interferon (PEG-IFN) has been widely used in the treatment of polycythemia vera (PV), there is still a significant variability its specific dosage and administration. This single-center retrospective study assessed efficacy safety PEG-IFN JAK2V617F-positive PV patients using dose de-escalation strategy. From 2018 to 2022, 110 received monitored for JAK2V617F variant allele frequency (VAF) over 12 months, with 95.4% achieving complete hematological response (CHR) 70.8%...
ABSTRACT The discovery of the MAPK pathway mutations in lesions patients with Langerhans cell histiocytosis (LCH) has made targeted therapy an important therapeutic approach for these patients. Theoretically, RAF‐independent mutation MAP2K1 E102_I103del is naturally resistant to allosteric MEK inhibitors. We report a dramatic response inhibitor trametinib case LCH mutation, which indicates that worth trying recurrence and refractory . Trial Registration : authors have confirmed clinical...
In order to study the CXCR4 expression with [68Ga]pentixafor PET in different types of non-Hodgkin lymphoma, we performed a retrospective describe PET/CT imaging spectrum lymphomas and compare it [18F]FDG PET/CT.Twenty-seven patients newly diagnosed lymphoma were recruited retrospectively. showed increased radioactivity lymphoplasmacytic (n = 8), marginal zone 4), diffuse large B cell 3), follicular 2), mantle 1), unclassified indolent enteropathy associated T 3). However, peripheral not...
Magnetic resonance imaging (MRI) is widely used for the evaluation of knee injuries, however, accuracy MRI in classifying multiple ligament injuries (MLKIs) remains unknown. This study aimed to investigate diagnosing and acute traumatic MLKIs, we hypothesize that had high detecting MLKIs.The clinical data 97 patients who were diagnosed with MLKIs managed by multi-ligament reconstruction between 2012 2020 retrospectively reviewed. The MR images read two experienced radiologists results...