A5103508679- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- interferon and immune responses
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Lymphocytic Leukemia Research
- Chemokine receptors and signaling
- Neuroendocrine Tumor Research Advances
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Power System Optimization and Stability
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- HVDC Systems and Fault Protection
- Anodic Oxide Films and Nanostructures
- Photochromic and Fluorescence Chemistry
- Retinal Development and Disorders
- Ubiquitin and proteasome pathways
- Process Optimization and Integration
- Phosphodiesterase function and regulation
- Viral-associated cancers and disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Peripheral Neuropathies and Disorders
- Parathyroid Disorders and Treatments
- MicroRNA in disease regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Peking Union Medical College Hospital
2015-2025
Liaoning University of Traditional Chinese Medicine
2025
Capital Medical University
2025
Beijing Ditan Hospital
2025
Tsinghua University
2006-2022
Air Force General Hospital PLA
2018
Universität Ulm
2013
Heidelberg University
2013
Illumina (United States)
2010
Abstract Adiponectin is an important insulin‐sensitizing adipokine with multiple beneficial effects on obesity‐associated medical complications. It secreted from adipocytes into circulation as high, medium, and low molecular weight forms (HMW, MMW, LMW). Each oligomeric form of adiponectin exerts non‐overlapping biological functions, the HMW oligomer possessing most potent activity. In this study, we reported that emodin, a natural product active ingredient various Chinese herbs, activates...
Histone deacetylase (HDAC) inhibitors have been shown to reverse epigenetic repression of certain genes, including retinoic acid receptor beta2 (RARbeta2). In this study, we examined whether RARbeta2 expression is repressed in human renal cell carcinoma (RCC) and the HDAC inhibitor MS-275 may revert its repression.Six tumor RCC lines were analyzed for gene methylation acetylation status at promoter level. Modulation correlation with antitumor activity by combination 13-cis-retinoic (CRA) was...
In acute myeloid leukemia (AML) without retinoic acid receptor (RAR) rearrangement, the effect of all-trans-retinoic (ATRA) is still poorly understood despite an association NPM1 mutation and ATRA response. Recently, preferentially expressed antigen in melanoma (PRAME) has been shown to be a dominant repressor RAR signaling.Thus, we further investigated response mechanisms, especially impact PRAME expression on responsiveness. We profiled gene diagnostic samples derived from our AML HD98B...
Alterations in DNA methylation have been proposed as a mechanism for the complex toxicological effects of arsenic. In this study, whole-genome and gene expression changes were evaluated lungs from female mice exposed 90 days to 50 ppm arsenate (As) drinking water. measured using reduced representation bisulfite deep sequencing. Differential was observed approximately 700 1900 start transcribed regions, respectively. The regions showed bias toward decreased methylation. No region. A...
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The incidence of chronic hepatitis B (CHB) combined with metabolism-associated fatty liver disease (MAFLD) is increasing annually, and the presence MAFLD may influence clinical assessment viral activity transaminase levels. However, it remains unclear whether impacts achievement cure in CHB patients treated polyethylene glycol interferon (Peg-IFN). A prospective cohort study was conducted to enroll dominant (on NA treatment, HBsAg <1,500 IU/mL, HBeAg negative, HBV DNA <10 IU/mL) MAFLD, all...
Idiopathic multicentric Castleman disease (iMCD) is a rare characterized by polyclonal lymphoproliferation and systemic inflammation. Siltuximab, targeting interleukin-6 (IL-6), has been recommended as the first-line therapy for iMCD. However, substantial real-world data from China were still lacking, treatment patients with severe iMCD remained challenging. This single-center retrospective study investigated efficacy safety of siltuximab-based in 43 consecutive July 2022 to March 2024. The...
Curdlan is an important biomacromolecule whose bioactivity strongly depending on its supramolecular structures. We have demonstrated that atomic force microscopy (AFM)-based single-molecule spectroscopy (SMFS) able to recognize triple- and double-helical structures random coils in curdlan, which are controlled by the concentration of sodium hydroxide. obtained information about force-induced conformation transition dynamics curdlan at molecular level.
RRAM is a promising candidate to implement large-capacity in-memory computing on edge AI devices due its high density. However, the efficiency and accuracy of RRAM-based computing-in-memory (CIM) works are limited by large accumulation currents device variations. The SRAM-based digital CIM achieves superior performance while adder tree dominates area. In this brief, macro proposed achieve better trade-off between accuracy, energy, three techniques. First, dynamic voltage sense amplifier...
Comfrey is consumed by humans as a vegetable and tea, has been used an herbal medicine for more than 2000 years. Comfrey, however, hepatotoxic in livestock carcinogenic experimental animals. Our previous study suggested that comfrey induces liver tumors genotoxic mechanism the pyrrolizidine alkaloids plant are responsible mutation induction tumor initiation rat liver.In this study, we identified comfrey-induced gene expression profile livers of rats. Groups 6 male transgenic Big Blue rats...
Background: Patients with amyloid light-chain (AL) amyloidosis who have advanced cardiac damage are at risk of premature mortality. Currently, bortezomib is the mainstay in treatment AL amyloidosis, but benefits patients ultra-high-risk (2004 Mayo stage IIIb or 2012 IV) not been proved definitively. Methods: We performed a retrospective analysis newly diagnosed received bortezomib-based regimen supportive treatment. aimed to establish effects on early mortality and long-term outcomes this...
Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor that exerts variety of effects, including anti-inflammatory, immunosuppressive, and anti-tumor effects. The aim this study was to investigate the effect rolipram on metabolic disorder its underlying mechanisms. Metabolic induced in 8-week-old wild type BABL/c mice by administration D-galactose for weeks. Simultaneously were administered vehicle or rolipram. Alternatively, beginning at 3 21 months, db-cAMP with without high-fat-diet...
An extrusion method, using anodic aluminium oxide (AAO) membranes as templates, has been developed to fabricate Nafion®-115 nanowire arrays. Surface decoration of the templates plays an important role in synthesis By sodium dodecyl sulfate (SDS) a surfactant surface decoration, filling rate nanowires corresponding template exceeds 95%, compared with 42% undecorated template, while on cetyltrimethylammonium bromide (CTAB) surfactant, is only about 20%. Systematical investigations show that...
Identifying novel differentiating agents to promote leukemia-cell differentiation is a pressing need. Here, we demonstrated that vibsanol A, vibsane-type diterpenoid, inhibited the growth of acute myeloid leukemia (AML) cells via induction cell differentiation, which was characterized by G1 cycle arrest. The differentiation-inducing effects A were dependent upon protein kinase C (PKC) activation, and subsequent activation extracellular signal-regulated (ERK) pathway. Furthermore, treatment...
Bubbles have been observed moving along heated wires during subcooled nucleate boiling as they are driven by Marangoni convection around the bubbles. This paper presents more detailed observations of vapor bubble interactions and behavior on a microwire. The experimental results show that bubbles coalesce or rebound from other hop wire. These how significantly affect heat transfer rates flow plays an important role in microscale mechanisms.
Interphotoreceptor retinoid binding protein (IRBP) is a and fatty acid glycoprotein secreted by rod cone photoreceptors in all vertebrates. IRBP believed to serve as carrier for retinoids the bleaching regeneration cycle of rhodopsin. has been found be decreased vitamin A-deprived rats; it rapidly recovered after retinol repletion. To understand mechanism this recovery, we determined whether A affects transcription translation gene. Wild-type transgenic mice harboring promoter-CAT reporter...
It is important to search voltage stability margin (VSM) of an interconnected power system in order determine secure operation constraints. Traditionally, centralised continuation flow (CPF) used, which may fail model the varied load growth directions different regional grids. In this study, a distributed VSM searching method proposed grounding on coordinated CPF (CCPF) performed by neighbouring dispatch centres. First, for established, considers automatic allocation network loss. Then,...