A5102829395- Effects of Radiation Exposure
- Acute Myeloid Leukemia Research
- TGF-β signaling in diseases
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Hematopoietic Stem Cell Transplantation
- Plant Molecular Biology Research
- Spine and Intervertebral Disc Pathology
- Light effects on plants
- Cancer, Hypoxia, and Metabolism
- Hematological disorders and diagnostics
- Tissue Engineering and Regenerative Medicine
- Histone Deacetylase Inhibitors Research
- NF-κB Signaling Pathways
- Cardiovascular Function and Risk Factors
- Immune Response and Inflammation
- Genetic factors in colorectal cancer
- Receptor Mechanisms and Signaling
- Cardiac Imaging and Diagnostics
- Cancer Research and Treatments
- Mesenchymal stem cell research
- Congenital heart defects research
- Spinal Fractures and Fixation Techniques
- Virus-based gene therapy research
- Peroxisome Proliferator-Activated Receptors
Beijing Radiation Center
2018-2025
Nanfang Hospital
2017-2024
Southern Medical University
2017-2024
Qi2
2023
Affiliated Hospital of Southwest Medical University
2020-2023
Academy of Military Medical Sciences
2013-2022
Nanjing Medical University
2021
Jiangsu Province Hospital
2021
First Affiliated Hospital of Sichuan Medical University
2020
Peking University
2015-2017
Smad3 and Smad4 are sequence-specific DNA-binding factors that bind to their consensus sites in response transforming growth factor β (TGFβ) activate transcription. Recent evidence implicates the transcriptional activation of AP-1 do not interact with Smads directly. Here, we report can physically family members. In vitro binding studies demonstrate both all three Jun members: JunB, cJun, JunD. The Smad interacting region JunB maps a C-terminal 20-amino acid sequence is partially conserved...
Adult mesenchymal stem cells (MSCs) derived from bone marrow contribute to the regeneration of multiple types tissues. Here we describe functional role a novel form cross-talk between transforming growth factor beta1 (TGF-beta1) and Wnt signaling pathways in regulating activities human MSCs. We show that TGF-beta1 induces rapid nuclear translocation beta-catenin MSCs Smad3-dependent manner. Functionally, this pathway is required for stimulation MSC proliferation inhibition osteogenic...
Smads are intermediate effector proteins that transduce the TGF-beta signal from plasma membrane to nucleus, where they participate in transactivation of downstream target genes. We have shown previously coactivators p300/CREB-binding protein involved TGF-beta-mediated two Cdk inhibitor genes, p21 and p15. Here we examined possibility function regulate transcription by directly interacting with protein. show Smad3 can interact a C-terminal fragment p300 temporal phosphorylation-dependent...
In buried seedlings, chloroplasts are arrested at the etioplast stage, but they rapidly mature upon emergence of seedling. Etioplast-chloroplast differentiation is halted through integration soil-induced signals, including pressure and absence light, although details on how this information converges to regulate cellular decisions remain unclear. Here, we identify an interdependent transcription module that integrates mechanical darkness signals control chloroplast development in Arabidopsis...
Transforming growth factor-β (TGF-β)can induce the cyclin-dependent kinase inhibitors p21 and p15 in a variety of cell types. We have shown previously that Smad3 is required for inhibitory activity TGF-β, whereas overexpression Smads not sufficient to activate expression HaCaT cells. These data suggest an additional signaling pathway may be involved stimulating Given recent finding mitogen-activated protein (MAPK) can cause induction arrest cells, we examined involvement this by TGF-β. found...
Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but rate of differentiation is low and mechanism unclear completely. Here, we aimed investigate role miR1-2 in mouse BMSCs cardiomyocyte-like reveal involved signaling pathways procedure.Mouse were treated with 5-azacytine (5-aza). The expression cardiac cell markers: NKx2.5, cTnI GATA4 examined by qPCR. apoptosis was detected flow cytometry activity Wnt/β-catenin pathway evaluated measuring...
To examine signaling pathways underlying transforming growth factor-beta (TGF-beta)-mediated changes in cell morphology, we used a microarray system to identify downstream target genes that may play role this process. Through approach, found the NET1 gene was induced upon TGF-beta treatment several types. is guanine nucleotide exchange factor for RhoA whose activity has been implicated stress fiber formation. In Swiss 3T3 line, induces expression, and correlated with an increase...
The seeds of terrestrial flowering plants often start their life cycle in subterranean darkness. To protect the fragile apical meristematic tissues and cotyledons from mechanical injuries during soil penetration, dicotyledonous seedlings form an elegant hook at top hypocotyl. has been considered as adaption structure to environment. However, role seedling emergence molecular mechanism formation under real-life conditions remain highly speculative. Here, we find that HOOKLESS 1 (HLS1), a...
Transforming growth factor β (TGF-β) causes arrest in most cell types. TGF-β induces hypophosphorylation of retinoblastoma susceptibility gene 1 product (RB), which sequesters E2F factors needed for progression into S phase the cycle, thereby leading to cycle at G . It is possible, however, that E2F-RB complex induced by may bind sites and suppress expression specific genes whose promoters contain binding sites. We show here treatment HaCaT cells formation E2F4-RB E2F4-p107 complexes, are...
Abstract All-trans retinoic acid (ATRA)-based cell differentiation therapy has been successful in treating acute promyelocytic leukemia, a unique subtype of myeloid leukemia (AML). However, other subtypes AML display resistance to ATRA-based treatment. In this study, we screened natural, plant-derived vibsane-type diterpenoids for their ability induce cells, discovering that vibsanin A potently induced lines and primary blasts. The differentiation-inducing activity was mediated through...
Abstract Background This study aims to compare the clinical outcomes and safety of a novel hand-held retractor system-assisted Wiltse TLIF with that P-TLIF assess whether this system assisted can yield less paraspinal muscle injury. Methods 56 patients (P-TLIF: 26, TLIF: 30) were included in one year prospective controlled study. The operation time, intraoperative blood loss, postoperative drainage, mobilization discharge time recorded. evaluated by ODI, VAS, JOA, SF-36 scores (7 days, 3, 6,...
Transforming growth factor β (TGF-β) is the prototype of a large superfamily signaling molecules involved in regulation cell and differentiation. In certain patients infected with human immunodeficiency virus type 1 (HIV-1), increased levels TGF-β promoted production also impaired host immune system. an effort to understand events linking action HIV production, we show here that can stimulate transcription from HIV-1 long terminal repeat (LTR) promoter through NF-κB binding sites both HaCaT...
Exposure to medium and high doses of ionizing radiation (IR) can induce long-term bone marrow (BM) suppression. We previously showed that recombinant human thrombopoietin (rhTPO) significantly promotes recovery from hematopoietic-acute syndrome, but its effect on BM suppression remains unknown. C57BL/6 mice were exposed 6.5 Gy γ-rays total body irradiation (TBI) at a dose-rate 63.01 cGy per minute, the treated with rhTPO (100 μg; intramuscular injection) or vehicle 2 h after TBI. All killed...
Study Design. Retrospective observational study. Objective. To investigate factors associated with cervical kyphosis after laminoplasty. Summary of Background Data. Many are reportedly the deterioration curvature laminoplasty, including lordosis angle, spine range motion (ROM), T1 slope, and C2–7 sagittal vertical axis. Post-laminoplasty or is likely caused by multiple factors. There currently no consensus on these issues. Methods. Data patients treated laminoplasty for degenerative...
Pain hypersensitivity is the most common category of chronic pain and difficult to cure. Oxidative stress certain cells apoptosis, such as dorsal root ganglion (DRG) neurons, play an essential role in induction development hypersensitivity. The focus this study at a more specific molecular level. We investigated advanced oxidative protein products (AOPPs) inducing cellular mechanism underlying proapoptotic effect AOPPs. Normal rats were injected by AOPPs-Rat serum albumin (AOPPs-RSA) cause...
Breast cancer (BRCA) is the most common type of and second leading cause cancer-related death in women all over world. Metastasis to bone an indicator poor prognosis BRCA patients. This study aimed develop a prognostic score model for predicting metastasis patients with BRCA.
Ionizing radiation (IR)-induced hematopoietic injury has become a global concern in the past decade. The underlying cause of this condition is compromised reserve, and kind could result infection or bleeding, addition to lethal mishaps. Therefore, developing an effective treatment for imperative. Fluacrypyrim (FAPM) recognized inhibitor STAT3, which exhibits anti-inflammation anti-tumor effects disorders. In context, present study aimed determine whether FAPM serve as curative agent...