A5101712002- Acute Kidney Injury Research
- Meat and Animal Product Quality
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Wound Healing and Treatments
- Spine and Intervertebral Disc Pathology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Ferroptosis and cancer prognosis
- Child Nutrition and Feeding Issues
- Musculoskeletal pain and rehabilitation
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Neonatal and Maternal Infections
- Traditional Chinese Medicine Analysis
- Autoimmune and Inflammatory Disorders Research
- Spinal Cord Injury Research
- Food Security and Health in Diverse Populations
- Electrospun Nanofibers in Biomedical Applications
- Body Composition Measurement Techniques
- Protein Hydrolysis and Bioactive Peptides
- Food Industry and Aquatic Biology
- Lipid metabolism and disorders
Nanfang Hospital
2017-2025
Southern Medical University
2017-2025
China Medical University
2022-2025
Abbott (Singapore)
2022-2024
Hainan University
2021-2024
Peking University First Hospital
2017-2023
Peking University
2017-2023
First Affiliated Hospital of Zhengzhou University
2022-2023
Shandong Provincial Hospital
2022
Shandong First Medical University
2022
There is an increasingly strong association between sarcopenia and malnutrition in research findings. We aimed to determine the prevalence factors associated with community-dwelling older adults (≥ 65 years) at risk of based on Malnutrition Universal Screening Tool (MUST).This was a cross-sectional study 811 participants. Participants were recruited from general population, community centers, senior activity polyclinics, hospital. Community-dwelling participated study. Participants' data...
Acerola polysaccharides (ACPs) were purified from acerola (Malpighia emarginata DC.), a tropical fruit with strong antioxidant and anti-inflammatory activities. However, the biological activities of ACPs have barely been investigated. The present study was designed to investigate efficacy in treatment high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) C57BL/6 mice. Male mice fed treated different doses for 9 continuous weeks. NAFLD examined terms body weight, lipid...
The difference in the oxidative susceptibility of triacylglycerols and phospholipids effects same polyphenolic antioxidant on such dried scallops.
Background: Immune checkpoint inhibitors (ICIs) have shown efficacy in patients with metastatic urothelial cancer (mUC), however, only a small subset of could benefit from ICIs. Identifying predictive biomarkers ICIs mUC is clinical meaningful for patient stratification and administration. Methods: Clinical transcriptomic data treated cohort (IMvigor210 study) was utilized to explore the biomarkers. LASSO Cox regression performed construct model. The model trained tested cohort, then...
Allantoin has been reported as a promising biomarker for monitoring of oxidative stress in humans and widely utilized variety topical pharmaceuticals cosmetics. Currently, the detection allantoin is achieved by using chromatographic coupled techniques, which needs sample pre-extraction, derivatization, complex matrixes, expensive instrumentation. Herein we report both intense chemiluminescence with lucigenin chemiluminescent first time. The lucigenin–allantoin system demonstrated emission...
Food-borne bioactive peptides have shown promise in preventing and mitigating alcohol-induced liver injury. This study was the first to assess novel properties of Mactra chinenesis (MCPs) acute alcoholic injury mice, further elucidated underlying mechanisms associated with this effect. The results showed that MCPs can improve lipid metabolism by modulating AMPK signaling pathway, decreasing fatty acid synthase activity, increasing carnitine palmitoyltransferase 1a activity. Meanwhile,...
Trimeric phthalides in nature are rarely reported. This research successfully isolated three novel trimeric phthalides, triangesinenolides A-C (1-3), from Angelica sinensis. These compounds, derived Z-ligustilide via diverse linkage patterns, display intricate polycyclic skeletons. Their structures were confirmed by spectroscopic and crystallographic analyses. Unlike previously identified triangesinenolide C (3) is the first phthalide synthesized [2 + 2]/[4 2] cycloaddition. In vitro assays...
Increased differentiation or activity of osteoclasts is the key pathogenic factor postmenopausal osteoporosis (PMOP). N4‐acetylcytidine (ac4C) modification, catalyzed by Nat10, a novel posttranscriptional mRNA modification related to many diseases. However, its impact on regulating osteoclast activation in PMOP remains uncertain. Here, we initially observed that Nat10-mediated ac4C positively correlates with monocytes and low bone mass PMOP. The specific knockout Nat10 remodelin, inhibitor,...
Aldehydes are implicated in the development of hypertension. Trans, trans-2,4-decadienal (tt-DDE), a dietary α,β-unsaturated aldehyde, is widespread many food products. However, role tt-DDE pathophysiology hypertension remains unknown. This study was designed to investigate whether consumption evokes and explore mechanisms underlying such role. Sprague-Dawley rats were administered different concentrations tt-DDE. After 28 days, blood pressure endothelial function mesenteric arteries...
Pain hypersensitivity is the most common category of chronic pain and difficult to cure. Oxidative stress certain cells apoptosis, such as dorsal root ganglion (DRG) neurons, play an essential role in induction development hypersensitivity. The focus this study at a more specific molecular level. We investigated advanced oxidative protein products (AOPPs) inducing cellular mechanism underlying proapoptotic effect AOPPs. Normal rats were injected by AOPPs-Rat serum albumin (AOPPs-RSA) cause...
Intervertebral disc degeneration (IVDD) is closely associated with senescence. Annulus fibrosus (AF) cell senescence a crucial driver of AF tissue tearing and fissures, thereby exacerbating IVDD. Increased advanced oxidative protein products (AOPPs) were found in human degenerative discs aged rat may be involved This study aimed to explore the mechanism AOPPs-induced cells.The pathological effects AOPPs vivo investigated using lumbar persistent model caudal puncture model. Rat primary cells...
Common genetic risk variants for prostate cancer (PCa) have been identified at approximately 170 loci using genome-wide association studies (GWAS), most of which were in European populations. Recently, GWAS applied to a large Japanese cohort and 12 novel susceptibility associated with PCa risk. In this study, we aim investigate the Chinese population. The study data will be used promote control China. A total 235 patients 252 subjects (all unrelated) enrolled case-control study. Nine single...
Abstract Wound dressings with waterproof, breathable, and bacterial‐resistant properties are still rarely realized. In this work, a newly hydrogel‐based dressing is designed backing of expanded polytetrafluoroethylene (ePTFE) film. The ePTFE grafting polyvinylpyrrolidone (PVP) brush composited hydrogel successfully an adhesion energy ≈80 kJ m −2 . resultant composite, the contributes excellent breathability, water resistance, bacterial barrier property. vapor transmission rate composite 4.83...
The aim of this study was to evaluate the effect lumbar sacralization on level vertebral slip and disc degeneration in patients with L4 spondylolysis.
This study investigated the effects of oral nutritional supplements (ONSs) along with dietary counseling (DC) in community-dwelling older adults at risk malnutrition. In this randomized controlled trial, 196 who were malnutrition, as identified by Malnutrition Universal Screening Tool (MUST) randomly assigned to receive ONSs twice daily DC (intervention) or DC-only (control) for 60 days. Primary outcome was change body weight from baseline day 60. Nutritional status, energy, and...
This study investigated lipid oxidation and aldehyde formation in roasted scallop during vitro gastrointestinal digestion, the effects of co-digestion antioxidant bamboo leaves (AOB) on this process. The results showed that contents hydroperoxides (LOOH), conjugated dienes (CD), Schiff bases (SB) were increased digestion. Besides, malondialdehyde (MDA) levels total decreased initially at gastric stage but intestinal stage. HPLC-ESI-MS/MS analysis hexanal (HEX), trans, trans-2,4-octadienal...
The main aim of this study was to determine the prevalence, capsular genotyping, antimicrobial susceptibility, and associated factors colonizing Group B Streptococcus (GBS) in pregnant women admitted a hospital Jinan, East China. Demographic data, clinical characteristics, vaginal rectal swabs were obtained from group expecting mothers subjected GBS screening at late stage pregnancy who went into labor over period November 2019 October 2020. Identification determination resistance patterns...
Critically ill patients requiring renal replacement therapy (RRT) are at risk of disease-related bleeding. Systemic heparinization should be avoided. AN69ST, a polyethyleneimine-treated polyacrylonitrile (AN69) membrane hemofilter, can primed with heparin, improving its local anticoagulative activity. Prolonged intermittent RRT (PI-RRT) is shorter duration and cheaper, considered as an alternative to continuous RRT. This study was performed compare the success rate anticoagulant-free PI-RRT...
This study aimed to elucidate the coagulation disorders in non-ICU patients with acute kidney injury (AKI) and their contribution clotting-related outcomes of intermittent replacement therapy (KRT).We included non-ICU-admitted AKI requiring KRT, clinically having a risk bleeding against systemic anticoagulant use during KRT between April December 2018. The premature termination treatment due circuit clotting was considered poor outcome. We analyzed characteristics thromboelastography...