The degradation process of returned straw in rice fields can improve soil organic matter and promote sustainable agriculture. is a humification as well mineralization involving microorganisms enzymes. However, the straw, effect on decomposing regulatory mechanism potential functionality under cool climate flooding conditions are currently unknown.For this purpose, we investigated biodegradation from point view at 20, 40, 71, 104, 137 d after return conventional (130 kg hm-2), 1/3 (2933 2/3...

Abstract Straw is an important source of organic fertilizer for soil enrichment, however, the effects different nitrogen(N) application rates and depths on straw decomposition microorganisms carbon nitrogen cycling under full return conditions in cool regions Northeast China are not clear at this stage. In paper, we applied macro-genome sequencing technology to investigate N (110 kg hm −2 , 120 130 140 150 ) (0–15 cm, 15–30 cm) decomposing paddy fields zone China. The results showed that (1)...

In recent years, Artocarpus heterophyllus Lam. (jackfruit) polysaccharides (namely JFP-Ps) have attracted much attention due to their multiple biological activities. This study aimed explore the protective effects and underlying mechanisms of JFP-Ps on cyclophosphamide (Cp)-induced liver damage. The effect was evaluated using HE staining, antioxidant testing, enzyme-linked immunosorbent assay (ELISA), real-time quantitative polymerase chain reaction (RT-qPCR), Western blot ultra-performance...

Food-borne bioactive peptides have shown promise in preventing and mitigating alcohol-induced liver injury. This study was the first to assess novel properties of Mactra chinenesis (MCPs) acute alcoholic injury mice, further elucidated underlying mechanisms associated with this effect. The results showed that MCPs can improve lipid metabolism by modulating AMPK signaling pathway, decreasing fatty acid synthase activity, increasing carnitine palmitoyltransferase 1a activity. Meanwhile,...

BACKGROUND: LncRNAs, miRNAs, and the sponge effect between them exert diverse biological influences on pathogenesis progression of coronary artery disease (CAD), thus necessitating an exploration lncRNA-miRNA-gene regulatory network in CAD.METHODS: Expression profile GSE98583 was obtained from NCBI, containing data 12 CAD patients 6 controls. Limma package utilized to determine differentially expressed genes (DEGs). Functional enrichment analysis performed by DAVID. The CAD-related miRNA-DEG...

Abstract The main purpose of this study was to investigate the improvement effect and serum metabolomic analysis co‐fermented collagen peptide‐jackfruit juice (FPJ) against immunosuppression in cyclophosphamide‐induced mice. Serum samples were analyzed using ultra‐performance liquid chromatography coupled with mass spectrometry (UPLC‐MS/MS) targeted metabolomics technology, including normal group, model FPJ determine if such treatments able revert immunosuppression‐related metabolic changes...

Soluble interleukin‐6 receptor (sIL‐6R) was found to be spontaneously released from human myeloma cell line U266 cells into culture supernatant, and quantitatively measured with a fluorescence sandwich enzyme‐linked immunosorbent assay employing antibodies specific IL‐6R. The supernatant IL‐6R generated only IL‐6R‐positive lines; lines RPMI8226 RPMI1788, myelomonocytic U937, THP‐1, HL‐60. In contrast, it not the IL‐6R‐negative cells; T MoIt‐4 Burkitt lympboma Raji. SDS‐PAGE analysis of...

This study aimed to obtain high Fischer's ratio oligopeptides from goat whey (HFO) and investigate antioxidant property of it. Hydrolysis was done with the approach sequential digestion pepsin flavourzyme. With adsorption aromatic amino acids by activated carbon, HFO a 27.070 molecular weight 200-1,000 Da were obtained, branched-chain accounted for 22.87%. Then activity evaluated. At concentrations 2.0 mg/mL 0.50 mg/mL, scavenged 77.27% 99.63% 1,1-diphenyl-2-picrylhydrazyl...

Cervical carcinoma (CC) is the one of most common gynecologic cancers worldwide. The ribosomal proteins (RPs) are essential for ribosome assembly and function, it has been verified that abnormal expression RPs was closely associated with tumorigenesis. In this study, we found RP large subunit 24 (RPL24) level upregulated after CC cell lines SiHa HeLa were treated Cisplatin (CDDP) in vitro . Simultaneously, a nude mouse xenograft model used to examine effect RPL24 on tumor growth vivo , which...

NUT carcinoma (NC) is a rapidly progressing and rare neoplasm that primarily affects younger patients has survival time of about 1 year. Most these neoplasms express epithelial markers with no neuroendocrine observed. Retrospective studies have shown pathologists clinicians do not sufficient understanding the disease due to lack common clinical manifestations, imaging, morphological features.A 60-year-old female presented at Beijing Friendship Hospital, showing repetitive epistaxis, nasal...

The escalating prevalence of diabetes globally underscores the need for management. Recent research highlights growing focus on digital biomarkers in management, with innovations computational frameworks and noninvasive monitoring techniques using personalized glucose metrics. However, they predominantly insulin dosing specific values, or limited attention given to overall glycemic control. This leaves a gap expanding scope control To address such gap, we propose GluMarker - an end-to-end...

An in vitro gastrointestinal digestion model was applied to investigate the effect of on phenolic compounds and antioxidant capacity

Selective androgen receptor modulators (SARMs), because of their preferential muscle vs prostate selectivity, are being developed for muscle-wasting conditions. Oral SARMs suppress high-density lipoprotein cholesterol (HDL-C) but effects on functional capacity and atherogenic potential HDL particles unknown.To determine the an oral SARM (OPK-88004) efflux capacity, particle number size, apolipoprotein size subspecies.We measured (CEC); size; APOB; APOA1; protein-defined subspecies associated...

The escalating prevalence of diabetes globally underscores the need for management. Recent research highlights growing focus on digital biomarkers in management, with innovations computational frameworks and noninvasive monitoring techniques using personalized glucose metrics. However, they predominantly insulin dosing specific values, or limited attention given to overall glycemic control. This leaves a gap expanding scope control To address such gap, we propose GluMarker -- an end-to-end...

Plants repair their mechanical wounds by reprogramming secondary metabolism. However, which genes are reprogrammed during this process in Aquilaria sinensis has rarely been studied. Here, we used high-throughput RNA sequencing to explore the changes transcriptome of Aquilaria’s xylem, six months after stem was subjected wounding. In total, 1165 transcripts were differentially accumulated, 1002 increased and 163 decreased abundances (|log2 (fold change)| ≥ 1 FDR ≤ 0.05). The majority these...

This study investigates the degradation characteristics, bacterial community structure, and mechanism of rice straw under different levels nitrogen (N) application depths return 1-mature-winter tillage in paddy fields a cold zone from perspective biodegradation by using nylon mesh bag situ culture method. Paludibacteraceae Ruminococcaceae were dominant bacteria process, their abundance decreased with increasing depth return. The activities extracellular enzymes associated C-cycle...