A5102931388- RNA Research and Splicing
- Immune Cell Function and Interaction
- Vibration and Dynamic Analysis
- Sesame and Sesamin Research
- Fluid Dynamics and Vibration Analysis
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Stress, Anesthesia, and Immune Response
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Redox biology and oxidative stress
- Graphene and Nanomaterials Applications
- Medical and Biological Ozone Research
- RNA modifications and cancer
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Adrenal Hormones and Disorders
- Supramolecular Self-Assembly in Materials
- Wind and Air Flow Studies
- RNA and protein synthesis mechanisms
Southern Medical University
2023-2025
Nanfang Hospital
2024-2025
Soochow University
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Key Laboratory of Guangdong Province
2024
Shanghai Jiao Tong University
2018
Intervertebral disc degeneration (IVDD) is a worldwide disease that causes low back pain and reduces quality of life. Biotherapeutic strategies based on tissue engineering alternatives, such as intervertebral scaffolds, supplemented by drug-targeted therapy have brought new hope for IVDD. In this study, to explore the role mechanism MnO2/GelMA composite hydrogels in alleviating IVDD, we prepared with MnO2 methacrylate gelatin (GelMA) characterized them using compression testing transmission...
Abstract Background Dysfunction of CD8 + T cells in the tumor microenvironment (TME) contributes to immune escape and immunotherapy tolerance. The effects hormones such as leptin, steroid hormones, glucocorticoids on cell function have been reported previously. However, mechanism underlying thyroid‐stimulating hormone (TSH)/thyroid‐stimulating receptor (TSHR) signaling exhaustion evasion remain poorly understood. This study was aimed at investigating TSH/TSHR colorectal cancer (CRC). Methods...
Background: Oxidative stress contributes to the development of prostate adenocarcinoma (PRAD). However, prognosis prediction and therapy response predicted based on oxidative stress-associated genes lacked comprehensive study. Herein, an integrated bioinformatics approach was adopted identify prognosis-associated for PRAD. Methods: From Gene-Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases, transcriptomic data clinical were collected. Genes related retrieved from pathway...
Increased differentiation or activity of osteoclasts is the key pathogenic factor postmenopausal osteoporosis (PMOP). N4‐acetylcytidine (ac4C) modification, catalyzed by Nat10, a novel posttranscriptional mRNA modification related to many diseases. However, its impact on regulating osteoclast activation in PMOP remains uncertain. Here, we initially observed that Nat10-mediated ac4C positively correlates with monocytes and low bone mass PMOP. The specific knockout Nat10 remodelin, inhibitor,...
Carbon nanotubes (CNTs), members of the nanomaterial family, are increasingly being used in consumer products and extensively studied for various biomedical applications. Due to their benign elemental composition, large surface area, chemical biological activities, CNTs demonstrate great potential cancer therapy, including drug delivery, imaging analysis, photothermal photodynamic radiotherapy. However, there is still a major knowledge gap when it comes transitioning from research clinical...
Abstract Osteosarcoma (OS) is a heterogeneous malignant spindle cell tumor that aggressive and has poor prognosis. Although combining surgery chemotherapy significantly improved patient outcomes, the prognosis for OS patients with metastatic or recurrent remained unsatisfactory. Therefore, it imperative to gain fresh perspective on development mechanisms treatment strategies. After studying single-cell RNA sequencing (scRNA-seq) data in public databases, we identified seven subclonal types...
Dysfunction of CD8+ T cells in the tumor microenvironment (TME) contributes to immune escape and immunotherapy tolerance, malignant are involved immunosuppression TME. However, specific underlying mechanism colorectal cancer (CRC) remains poorly understood. Here, we show that thyroid stimulating hormone receptor (TSHR) plays a pivotal role regulating cell exhaustion TME CRC. We identified TSH/TSHR signaling as intrinsic pathway for exhaustion. Conditional deletion TSHR tumor-infiltrating...