A5014556910- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Brain Metastases and Treatment
- Diet, Metabolism, and Disease
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- HER2/EGFR in Cancer Research
- SARS-CoV-2 detection and testing
- Hearing Loss and Rehabilitation
- Cerebral Venous Sinus Thrombosis
- Ear and Head Tumors
- Autophagy in Disease and Therapy
- Nitric Oxide and Endothelin Effects
- Cancer-related gene regulation
- Vestibular and auditory disorders
- Heart Failure Treatment and Management
- Renin-Angiotensin System Studies
- COVID-19 diagnosis using AI
- Nutrition, Genetics, and Disease
- Diabetes and associated disorders
- Lipid metabolism and biosynthesis
- SARS-CoV-2 and COVID-19 Research
- RNA regulation and disease
Northwestern University
2025
University of Delaware
2025
Massachusetts Eye and Ear Infirmary
2021-2024
Harvard University
2010-2024
Massachusetts General Hospital
2022
AstraZeneca (France)
2021
University of Utah
2020
Center for Human Genetics
2010
Virginia Mason Medical Center
2000
University Children’s Hospital Bern
1980
COVID-19 is a pandemic respiratory and vascular disease caused by SARS-CoV-2 virus. There growing number of sensory deficits associated with molecular mechanisms underlying these are incompletely understood.
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic globally. NAFLD a consequence fat accumulation in to lipotoxicity. Increasing evidence has demonstrated critical role autophagy NAFLD. This study uncovers unexpected immune surveillance protein DDX58/Rig-1 (DExD/H box helicase 58) activating macroautophagy/autophagy and protecting from lipotoxicity associated with Here we show for first time that DDX58 significantly reduced nonalcoholic steatohepatitis (NASH) mouse...
Normalizing the tumor microenvironment with losartan prevents tumor-induced hearing loss and enhances radiation response in schwannoma rodent models.
Vestibular schwannoma (VS) is a non-malignant intracranial neoplasm arising from the vestibular branch of 8th cranial nerve; sensorineural hearing loss (SNHL) most common associated symptom. Understanding whether VS imaging characteristics at time diagnosis can be with severity VS-induced SNHL impact patient counseling and define promising areas for future research. Patients diagnosed Massachusetts Eye Ear (MEE) 1994 through 2018 were analyzed if magnetic resonance presentation sequential...
<h3>Importance</h3> <i>International Statistical Classification of Diseases and Related Health Problems, Tenth Revision </i>(<i>ICD-10</i>) codes are used to characterize coronavirus disease 2019 (COVID-19)–related symptoms. Their accuracy is unknown, which could affect downstream analyses. <h3>Objective</h3> To compare the performance fever-, cough-, dyspnea-specific<i>ICD-10</i>codes with medical record review among patients tested for COVID-19. <h3>Design, Setting, Participants</h3> This...
Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells and typically presenting with hearing loss. The traditional belief that deficit caused by physical expansion of the VS, compressing auditory nerve, does not explain common clinical finding patients small tumors can have profound loss, suggesting tumor-secreted factors could influence ability in VS patients. We conducted profiling patients’ plasma for 66 immune-related sporadic ( N > 170) identified...
Objective(s) Recently directed methods of inner ear drug delivery underscore the necessity for understanding critical anatomical dimensions. This study examines measurements human middle and relevant studied with three different imaging modalities. Methods Post‐mortem temporal bones were analyzed using bone histopathology ( N = 24), micro computerized tomography (μCT; 4), synchrotron radiation phase‐contrast (SR‐PCI; 7). Nine involving oval round windows performed when structures visualized...
Introduction: Adverse Childhood Experiences (ACEs) are used as an indicator of childhood trauma. Two-thirds the United States population has experienced at least one ACE. Research indicates there is a relationship between ACEs and unhealthy behaviors, such smoking physical inactivity, that increase one’s risk for cardiovascular diseases. Very few studies have analyzed how impact dietary patterns, another factor disease, increasing hypertension (HTN). This study aimed to explore number...
Abstract The United States (US), which is currently the epicenter for COVID-19 pandemic, a country whose demographic composition differs from that of other highly-impacted countries. US-based descriptions SARS-CoV-2 infections have, most part, focused on patient populations with severe disease, captured in areas limited testing capacity. objective this study to compare characteristics positive and negative patients, population primarily comprised mild moderate infections, identified...
Objective To validate how an automated model for vestibular schwannoma (VS) segmentation developed on external homogeneous dataset performs when applied to internal heterogeneous data. Patients The comprised 242 patients with previously untreated, sporadic unilateral VS undergoing Gamma Knife radiosurgery, magnetic resonance imaging (MRI) scans. 10 from our institution, MRI Interventions An was the dataset. tested Main Outcome Measure Dice score, which measures agreement between ground truth...
Sensorineural hearing loss (SNHL), which typically arises from the inner ear, is most common sensory deficit worldwide. The traditional method for studying pathophysiology underlying human SNHL involves histological processing of ear temporal bones collected during autopsy. Histopathological analysis destructive and limits future use a given specimen. Non-destructive strategies study are urgently needed to fully leverage utility each specimen because access increasingly difficult these...
The number of individuals with non-alcoholic fatty liver disease (NAFLD) is at epidemic levels worldwide. Although thought as benign, NAFLD can progress to more severe forms the that include steatohepatitis (NASH), fibrosis, cirrhosis, and in some cases hepatocellular carcinoma. Presently no therapies exist treat and/or NASH even though this area drug discovery has been highly active. accumulation triglycerides acids are linked initiation progression NAFLD. Intestinal monoacylglycerol...