A5060896904- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Pancreatitis Pathology and Treatment
- Cervical Cancer and HPV Research
- Cancer Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- TGF-β signaling in diseases
- Mitochondrial Function and Pathology
- Caveolin-1 and cellular processes
- SARS-CoV-2 and COVID-19 Research
- Vector-borne infectious diseases
- Agriculture and Farm Safety
- Clusterin in disease pathology
- Hematological disorders and diagnostics
- COVID-19 Clinical Research Studies
- Poxvirus research and outbreaks
- Endometrial and Cervical Cancer Treatments
- Circadian rhythm and melatonin
- Virus-based gene therapy research
- Cancer-related gene regulation
- Genital Health and Disease
New York University
2020-2025
NYU Langone Health
2024
Tel Aviv University
2014-2017
Weizmann Institute of Science
2015
Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes evolution contributes to therapeutic resistance. Here, we demonstrate PDA cell-derived proinflammatory cytokine IL1β essential for the establishment of protumorigenic microenvironment. Tumor promoted activation secretory phenotype quiescent pancreatic stellate cells established immunosuppressive milieu mediated M2 macrophages,...
// Beny Shapiro 1, * , Piera Tocci Gal Haase 1 Nancy Gavert Avri Ben-Ze'ev Department of Molecular Cell Biology, The Weizmann Institute Science, Rehovot, 76100, Israel These authors have equally contributed to this work Correspondence to: Ben-Ze'ev, e-mail: avri.ben-zeev@weizmann.ac.il Keywords: clusterin, L1, colon cancer, metastasis Received: May 12, 2015 Accepted: September 07, Published: 19, ABSTRACT Hyperactive Wnt signaling is a common feature in human colorectal cancer (CRC) cells. A...
Objective: Identify how surgical resection of pancreatic ductal adenocarcinoma (PDAC) affects systemic minimal residual disease (MRD). Methods: Pancreatic tumors were generated by orthotopic implantation tumor cells into the pancreas immunocompetent mice. Tumor was carried out via distal pancreatectomy and splenectomy. Liver metastases microenvironment immune changes analyzed in resected vs. non-resected Results: Resection accompanied proliferative expansion liver an increase hepatic...
Abstract The majority of pancreatic ductal adenocarcinoma (PDAC) patients are metastatic at presentation with limited treatment options and a poor overall 5-year survival 3%. liver is the predominant site distant metastasis in PDAC. Our group has previously shown that aerobic exercise can inhibit tumorigenesis primary PDAC mouse model by promoting anti-tumor immunity, however, effects setting have not been explored. As such, we developed isolating cell lines from 18–20-week-old...
Abstract Surgical resection is currently the mainstay of treatment for pancreatic ductal adenocarcinoma (PDAC). After “curative intent” resection, distant metastasis occurs in majority patients, indicating that PDAC a systemic disease and should be considered as such at time surgical resection. Despite this, effects tumor on are not fully elucidated. trauma induces immunosuppression, can result “window opportunity”, affecting metastatic seeding outgrowth, well responsiveness to therapy. We...
<h3>Abstract</h3> If a health care workers (HCW) experiences COVID-19 associated symptoms, SARS-CoV-2 testing must be performed as soon possible, to prevent transmission of the virus and guarantee continuity care. The gold standard for detection SARS-CoV-2, RT-PCR, has high sensitivity but usually takes 6-8 hours. Lateral flow antigen assays take only 15-30 minutes do not need any tech equipment. In prospective study our hospital’s HCWs, we evaluated Panbio™ Ag Rapid Test (Abbott) against...
<p>Supplementary Methods</p>
<p>IL-1b neutralization sensitizes PDA tumors to PD-1 checkpoint blockade.</p>
<p>IL-1b neutralization sensitizes PDA tumors to PD-1 checkpoint blockade.</p>
<p>NLRP3 inflammasome regulates pro-IL-1b processing in pancreatic tumor cells.</p>
<p>Supplementary Methods</p>
<p>Tumor cell-derived IL-1b regulates pancreatic stellate cell activation and inflammatory functions.</p>
<p>TLR4 signaling induces IL-1b expression in tumor cells response to the pancreatic microbiome.</p>
<p>TLR4 signaling induces IL-1b expression in tumor cells response to the pancreatic microbiome.</p>
<p>NLRP3 inflammasome regulates pro-IL-1b processing in pancreatic tumor cells.</p>
<p>Tumor cell-derived IL-1b regulates pancreatic stellate cell activation and inflammatory functions.</p>
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes evolution contributes to therapeutic resistance. Here, we demonstrate PDA cell–derived proinflammatory cytokine IL1β essential for the establishment of protumorigenic microenvironment. Tumor promoted activation secretory phenotype quiescent pancreatic stellate cells established immunosuppressive milieu mediated...
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes evolution contributes to therapeutic resistance. Here, we demonstrate PDA cell–derived proinflammatory cytokine IL1β essential for the establishment of protumorigenic microenvironment. Tumor promoted activation secretory phenotype quiescent pancreatic stellate cells established immunosuppressive milieu mediated...
<p>Tumor cell-derived IL-1b regulates stromal immune cell profile and production.</p>