A5072058867- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Polyomavirus and related diseases
- Phagocytosis and Immune Regulation
- Gut microbiota and health
- Exercise and Physiological Responses
- CAR-T cell therapy research
- Inflammatory Biomarkers in Disease Prognosis
- Endometrial and Cervical Cancer Treatments
- Gastrointestinal motility and disorders
- IL-33, ST2, and ILC Pathways
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
New York University
2021-2025
NYU Langone Health
2022-2024
University School
2021
The gut microbiome shapes local and systemic immunity. liver is presumed to be a protected sterile site. As such, hepatic has not been examined. Here, we showed in mice humans that distinct from of the enriched Proteobacteria. It undergoes dynamic alterations with age influenced by environment host physiology. Fecal microbial transfer experiments revealed populated highly selective manner. Hepatic immunity dependent on microbiome, specifically bacteroidetes species. Targeting oral...
Objective: Identify how surgical resection of pancreatic ductal adenocarcinoma (PDAC) affects systemic minimal residual disease (MRD). Methods: Pancreatic tumors were generated by orthotopic implantation tumor cells into the pancreas immunocompetent mice. Tumor was carried out via distal pancreatectomy and splenectomy. Liver metastases microenvironment immune changes analyzed in resected vs. non-resected Results: Resection accompanied proliferative expansion liver an increase hepatic...
Abstract The majority of pancreatic ductal adenocarcinoma (PDAC) patients are metastatic at presentation with limited treatment options and a poor overall 5-year survival 3%. liver is the predominant site distant metastasis in PDAC. Our group has previously shown that aerobic exercise can inhibit tumorigenesis primary PDAC mouse model by promoting anti-tumor immunity, however, effects setting have not been explored. As such, we developed isolating cell lines from 18–20-week-old...
Abstract Tumor-infiltrating immune cells play a central role in controlling cancer development and progression, as well responses to therapeutic interventions. However, the mechanisms that control their mobilization, composition, function are not completely understood. Here, we show aerobic exercise is sufficient induce an intra-tumoral expansion of activated CD8 T reduction tumor growth murine models pancreatic cancer. Specifically, exercise-induced spikes epinephrine promote systemic...