A5000852709- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Health and Wellbeing Research
- Renal and related cancers
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Anomalies and Fetal Surgery
- Esophageal and GI Pathology
- TGF-β signaling in diseases
- Nutrition and Health in Aging
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Nitric Oxide and Endothelin Effects
- Neonatal Respiratory Health Research
- Liver Disease and Transplantation
- Neuroscience and Neuropharmacology Research
Yeouido St. Mary's Hospital
2025
Catholic University of Korea
2023-2025
Pusan National University Yangsan Hospital
2023-2025
CHA Bundang Medical Center
2020-2025
CHA University
2023-2025
University of Ulsan
1999-2024
Ulsan College
1999-2024
Asan Medical Center
1999-2024
Kyung Hee University
2024
Seoul National University Hospital
2023
Osteoporosis and sarcopenia are common health problems in postmenopausal women. However, studies of these issues premenopausal women limited. Our present study aimed to investigate relationship the between underweight, bone mineral density (BMD) skeletal muscle index (SMI) a representative sample Korean women.We used data from Korea National Health Nutrition Examination Surveys (2009-2010). Participants included 1767 healthy, ≥ 20-year-old, non-obese Underweight was defined as BMI< 18.5...
In Brief OBJECTIVE: Imbalance between angiogenesis-related factors is closely related to the development of preeclampsia. The objective was estimate most effective and accurate predictive biomarker among levels ratios factors, including soluble fms-like tyrosine kinase 1 (sFlt-1), endoglin, placental growth factor (PlGF), transforming factor-β1 (TGF-β1), in women who subsequently developed METHODS: A nested cohort study conducted sFlt-1, PlGF, TGF-β1 plasma collected second trimester from 40...
To investigate the risks of increasing maternal age on perinatal and obstetric outcomes. Information about 29,760 singleton pregnancies delivered between 2005 2008 was extracted from our database. Patients were categorized into four groups according to age: 20–29 years, 30–34 35–39 ≥40 years. Multivariable logistic regression analysis used evaluate adjusted odd ratios (AORs) adverse pregnancy outcomes after adjusting for parity, body mass index, medical history use in vitro fertilization....
The present study tested the cytoprotective effect of methyleugenol in an vivo ischemia model (i.e. middle cerebral artery occlusion (MCAO) for 1.5 h and subsequent reperfusion 24 h) further investigated its mechanism action vitro ischemic models. When applied shortly after reperfusion, largely reduced injury. Methyleugenol decreased caspase-3 activation death cultured cortical neurons caused by oxygen-glucose deprivation (OGD) 1 re-oxygenation h. markedly superoxide generation brain...
Abstract Background We hypothesized that portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) increases pressure and causes esophageal varices variceal bleedings. examined the incidence of high-risk bleeding determined indications for screening prophylaxis. Methods This study included 1709 asymptomatic patients without any prior history hemorrhage or endoscopic prophylaxis who underwent upper endoscopy within 30 days before after initial anti-HCC treatment. Of these...
Abstract In cerebral ischemic insults, activated inflammatory cells such as microglia and macrophages may be implicated in the pattern degree of injury by producing various bioactive mediators. present study, we provide evidence that microglia/macrophages accelerate overexpression inducible nitric oxide synthase (iNOS). To activate microglia/macrophages, a potent inflammation inducer lipopolysaccharide (LPS, 5 μg/5 μl) was microinjected into rat corpus callosum. Isolectin B4‐positive were...
Lipid membrane peroxidation is highly associated with neuronal death in various neurodegenerative diseases including cerebral stroke. Here, we report that simvastatin decreases oxygen and glucose deprivation (OGD)/reoxygenation-evoked by inhibiting the production cytoxicity of 4-hydroxy-2E-nonenal (HNE), final product lipid peroxidation. Simvastatin markedly decreased OGD/reoxygenation-evoked cortical neurons. OGD/reoxygenation increased intracellular HNE level mostly cells, not glial cells....
(S)-cis-verbenol, a natural metabolite from (-)-alpha-pinene of host pine tree, has been suggested to have anti-ischemic activity. However, the exact mechanism for activity (S)-cis-verbenol remains unclear yet. In present study, reduced cerebral ischemic injury caused by 1.5-h middle artery occlusion followed 24-h reperfusion. Furthermore, significantly prevented neuronal cell death oxygen-glucose deprivation (OGD, 1 h) and subsequent re-oxygenation (5 h). While did not inhibit...
Citation Kim SY, Park Choi JW, DJ, Lee Lim JH, Han JY, Ryu HM, MH. Association between MTHFR 1298A>C polymorphism and spontaneous abortion with fetal chromosomal aneuploidy. Am J Reprod Immunol 2011; 66: 252–258 Problem Polymorphisms in genes involved folate metabolism are commonly associated defects folate-dependent homocysteine metabolism, which can result DNA hypomethylation chromosome nondisjunction. This prospective study aimed to investigate the associations 677C>T, 1298A>C, MTR...
Non-invasive prenatal testing of trisomy 21 (T21) is being actively investigated using fetal-specific epigenetic markers (EPs) that are present in maternal plasma. Recently, 12 EPs on chromosome were identified based tissue-specific characteristics between placenta and blood, demonstrated excellent clinical performance the non-invasive detection fetal T21. However, disease-specific have not been established. Therefore, we validated these for use We performed a high-resolution tiling array...
Postpartum depression (PPD) can negatively affect infant well-being and child development. Although the frequency risk factors of PPD symptoms might vary depending on country culture, there is limited research these among Korean women. This study aimed to elucidate potential throughout pregnancy help improve screening prevention in The pregnant women at 12 gestational weeks (GW) were enrolled from two obstetric specialized hospitals March 2013 November 2017. A questionnaire survey was...
To assess longitudinally physical activity patterns and intensity from pre-pregnancy to postpartum evaluate the association between timing type of development gestational diabetes mellitus (GDM). The Korean Pregnancy Outcome Study (KPOS) is a prospective cohort study conducted 2013 2017. Our included 3,457 participants with singleton pregnancies in KPOS, classified according pregnancy outcome: GDM (n=231) normal (n=3,226). Physical data were collected at five time points using short form...
Abstract Purpose The guidance regarding routine induction therapy (IT) on direct-ECMO-bridged heart transplantation (ECMO-HTx) has not been established. To date, most of the evidence conducted non-ECMO patients. purpose this study is to investigate impact IT bridged by ECMO, which a high risk infection, and multiple organ failures. Methods We retrospectively reviewed 338 patients who underwent ECMO-HTx between 2014 2023 in Korean Organ Transplant Registry. Patients with dual transplants PRA...
Prolonged therapy using nucleos(t)ide analogs (NUC) is inevitable in patients with chronic hepatitis B (CHB) infection, but its long-term impact on Parkinson's disease (PD) risk remains unclear. This study evaluated the association between NUC and PD incidence a nationwide CHB cohort. The population comprised National Health Insurance Service claims database from January 1, 2013, to December 31, only included treatment naïve those without previously diagnosed PD. Participants were followed...
Anaemia during pregnancy is associated with maternal depressive symptoms and the postpartum period. However, effect of anaemia development on psychological health in non-anaemic women remains unclear. To investigate This study includes a secondary analysis data collected prospectively from Korean Pregnancy Outcome Study. Depression anxiety were evaluated each trimester 4-6 weeks postpartum. The Hospital Anxiety Scale was used for Edinburgh Postnatal depression. Among 3310 normal haemoglobin...
This study aimed to analyze the differences of soluble endoglin (sEng) and transforming growth factor-beta1 (TGF-beta1) according preeclamptic complications investigate correlation between these factors clinical symptoms preeclampsia.We estimated levels sEng TGF-beta1 in plasma collected second trimester at time genetic amniocentesis from 60 women who subsequently developed preeclampsia 124 contemporaneous normotensive women.sEng were higher cases than controls, whereas lower (P < 0.001)....
Abstract Elevation of total cell-free DNA (cfDNA) in patients with preeclampsia is well-known; however, whether this change precedes the onset symptoms remains inconclusive. Here, we conducted a nested case–control study to determine elevation cfDNA levels women who subsequently developed preeclampsia. Methylated HYP2 (m- ) were determined 68 blood samples collected from hypertensive disorders pregnancy, along 136 control samples, using real-time quantitative PCR. The measured m- converted...
Long-term therapy with nucleos(t)ide analogs (NUCs) is inevitable for chronic hepatitis B (CHB) patients. However, how NUC on the developing Alzheimer's disease (AD) in these patients remains controversial. This retrospective cohort study used Korean National Health Insurance Service claims database from January 1, 2013, to December 31, treatment naïve CHB and those without previously diagnosed AD. Participants were followed index date until either diagnosis of AD or study's conclusion 2021....
Laboratory of Medical Genetics, Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea