A5059033525- Bladder and Urothelial Cancer Treatments
- Urinary Tract Infections Management
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Ureteral procedures and complications
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Urologic and reproductive health conditions
- Advanced X-ray and CT Imaging
- Metabolism, Diabetes, and Cancer
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Advanced Radiotherapy Techniques
- Renal and related cancers
- Tuberous Sclerosis Complex Research
- Genetic and Kidney Cyst Diseases
- Urinary Bladder and Prostate Research
- Multiple and Secondary Primary Cancers
- Hormonal and reproductive studies
- Testicular diseases and treatments
- Escherichia coli research studies
Fukuyama City Hospital
2010-2025
Okayama University
2015-2023
Okayama University Hospital
2017-2021
Seoul Medical Center
2018
Nashville Oncology Associates
2018
Shimane University
2018
Onomichi General Hospital
2009-2010
Summary Locally advanced or metastatic urothelial cancer is an aggressive form of with high recurrence rates and low survival. Nectin-4 a cell adhesion molecule commonly expressed in several tumors, including expression cancer. Enfortumab vedotin antibody–drug conjugate composed anti-Nectin-4 humanized monoclonal antibody linked to the microtubule disrupting agent, monomethyl auristatin E. In this phase I study (NCT03070990), Japanese patients locally advanced/metastatic treated prior...
Abstract Objective To evaluate the real-world clinical usage and effectiveness of apalutamide in men with nonmetastatic castration-resistant prostate cancer (nmCRPC). Methods We retrospectively reviewed data 186 who received across 17 institutions. The primary outcomes were for nmCRPC: prior other androgen receptor signaling inhibitors (ARSIs), radical treatment, distribution prostate-specific antigen (PSA) doubling time (PSA-DT) at initial administration apalutamide. secondary efficacy...
725 Background: First-line chemotherapy with 4-6 cycles followed by avelumab 1L maintenance therapy is the standard of care in patients metastatic urothelial carcinoma (mUC). However, a non-negligible number received less than four due to adverse events, or pre-existing severe comorbidities our daily practice. Thus, we examined prognostic impact first-line mUC treated avelumab. Methods: In this multi-institutional study, collected data 91 who following 1 st -line chemotherapy. Patients were...
Purpose: Tuberous sclerosis complex (TSC) is a rare autosomal dominant inherited disease, in which approximately 60% to 80% of patients have bilateral angiomyolipoma (AML). There need for repeatable local treatments TSC-AML. Cryotherapy an option renal tumors; however, its safety and efficacy vascular tumors, such as TSC-AML, are unclear. The aim this study was establish the cryotherapy Materials Methods: This open-label, single-arm, prospective phase II evaluate TSC-AML ≤ 4 cm. performed...
A 38-year-old woman with a 2.7-cm left ureteral stenosis requiring chronic stent exchange elected to undergo robotic renal autotransplantation. Left ureteropelvic junction obstruction (UPJO) was also suspected. Robotic donor nephrectomy contributed the fine dissection for desmoplastic changes. The kidney removed through Gelport and examined on ice. UPJO not seen. An end-to-side anastomosis created between external iliac vessels. console time 507 min, warm ischemia 4 min 5 sec. She became...
Fluoroquinolone-non-susceptible Escherichia coli isolated from patients with acute uncomplicated cystitis are a matter of increasing concern. Cefditoren pivoxil is an oral, β-lactamase-stable, extended-spectrum cephalosporin that effective against fluoroquinolone-non-susceptible bacteria. To evaluate the clinical and microbiological efficacies cefditoren to determine optimal duration treatment. We compared 3 7 day regimens in multicentre, randomized, open-label study. A total 104 female were...
Abstract Background Japanese men receiving apalutamide often experience skin-adverse events (AEs), possibly requiring treatment interruption or dose reduction. However, concerns have arisen regarding the impact of these adjustments on efficacy apalutamide. Our study evaluated efficacy, safety, and persistence in with metastatic castration-sensitive prostate cancer (mCSPC). Methods We retrospectively reviewed medical records 108 mCSPC from 14 institutions. The primary outcomes were...
Abstract We compared the implant quality of intraoperatively built custom-linked (IBCL) seeds with loose in permanent prostate brachytherapy. Between June 2012 and January 2015, 64 consecutive cancer patients underwent brachytherapy IBCL ( n = 32) or 32). All were treated 144 Gy alone. Brachytherapy was performed using a dynamic dose calculation technique. Computed tomography/magnetic resonance imaging fusion-based dosimetry 1 month after Post-implant dose–volume histogram (DVH) parameters,...
The present case report describes a of recurrent and advanced urachal carcinoma including neuroendocrine features with iliac bone metastasis after partial cystectomy adjuvant chemotherapy consisting irinotecan cisplatin in 32-year-old man. He received gemcitabine/cisplatin/ paclitaxel (GCP) combination chemotherapy, gemcitabin (1,000mg/m2) on day 1, 8, (70mg/m2) (80mg/m2) 1 8. After three cycles PET-CT showed complete regression the disease. So patient underwent total cystourethrectomy,...
Abstract Background The advantages of photodynamic diagnostic technology using 5-aminolevulinic acid (ALA-PDD) have been established. aim this prospective cohort study was to evaluate the usefulness ALA-PDD diagnose upper tract urothelial carcinoma (UT-UC) Olympus VISERA ELITE video system. Methods We carried out a prospective, interventional, non-randomized, non-contrast and open label pilot that involved patients who underwent ureterorenoscopy (URS) detect UT-UC. hydrochloride orally...
Urinary tract infections (UTIs) are the most common bacterial in women, and many patients experience frequent recurrence. The aim of this report is to introduce an on-going prospective phase II clinical trial performed evaluate preventive effectiveness Lactobacillus vaginal suppositories for prevention recurrent cystitis. Patients enrolled study administered containing GAI 98322 strain crispatus every 2 days or 3 times a week one year. primary endpoint recurrence cystitis secondary endpoints...
Nephron-sparing treatment should be offered whenever possible to avoid dialysis in allograph cases. Cryoablation is a new option for treating small-sized renal cell cancer (RCCs). We report case of RCC arising kidney allograft treated by cryoablation. To our knowledge, this the first Asia using Contrast-enhanced CT-guided percutaneous needle biopsy and cryoablation were used identify RCC, which could not identified other techniques. The postoperative course was uneventful. CT also showed no...
(目的) 尾道市立市民病院人間ドックでのPSAによる前立腺癌検診の有用性について検討した． (方法) 1997年4月から2007年12月までの10年9カ月の間に当院人間ドックにおいてPSA単独による前立腺癌検診を施行した延べ1,234例（中央値59歳）を対象とし，PSAの陽性率，二次検診受診率，生検施行率，癌発見率および癌症例の治療成績と臨床的重要度について検討した． (結果)...
We report the case of a 58-year-old Japanese man with bilateral synchronous renal cell carcinoma (RCC). The diameters right and left tumors were 56 69 mm, respectively. Both endophytic. Cryoablation prophylactic embolization was performed for tumor, 1 month later, open partial nephrectomy performed. No recurrence observed during 16-month follow-up, serum creatinine level has been stable. prognosis RCC is better than that dialysis patients. novel approach combining cryoablation can achieve...
None declared.
Background Although immune checkpoint inhibitors (ICIs) are effective cancer drugs, ICI-induced diabetes is a rare but life-threatening adverse event for patients. The deleterious action of ICI on pancreatic beta-cell function concern. However, the influence insulin synthesis and secretion in patients with without remains unknown. Methods This study included 87 diagnosed advanced cancer. Glucose metabolism markers (HbA1c, HOMA-IR) indicators secretory capacity (HOMA-beta, C-peptide) were...
To determine whether neoadjuvant hormonal therapy improves oncological outcomes of patients with localized prostate cancer treated permanent brachytherapy.Between January 2004 and November 2014, 564 underwent transperineal ultrasonography-guided iodine-125 seed brachytherapy. We retrospectively analyzed low- or intermediate-risk based on the National Comprehensive Cancer Network guidelines. The clinical variables were evaluated for influence biochemical recurrence-free survival,...
Tape infection after insertion of tension-free vaginal tape is a well-known but rare complication. We report patient who experienced subcutaneous abscess 19 years the surgery.
Nephrectomy is a curative treatment for localized renal cell carcinoma (RCC), but patients with poor prognostic features may experience relapse. Understanding the impact of programmed death-ligand 1 (PD-L1) expression in who underwent nephrectomy RCC aid future development adjuvant therapy.Of 770 surgical specimens collected from Japanese enrolled ARCHERY study, only samples obtained recurrent after were examined this secondary analysis. Patients categorized into low- and high-risk groups...
137 Background: Japanese patients with prostate cancer (PC) treated apalutamide often encounter skin-adverse events (AE), which might lead to adjust the initial-dose of apalutamide. However, concerns have emerged regarding potential impact these dose adjustments on overall efficacy in real-world clinical practice. We aimed evaluate association between adjustment and outcome men metastatic castration-sensitive PC (mCSPC). Methods: retrospectively evaluated 108 mCSPC divided into two groups:...