A5049739469- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Sexual function and dysfunction studies
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Renal and related cancers
- Multiple Myeloma Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Biochemical Analysis and Sensing Techniques
- Biochemical effects in animals
- Genital Health and Disease
- Frailty in Older Adults
- Hormonal and reproductive studies
- Regulation of Appetite and Obesity
- Telomeres, Telomerase, and Senescence
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
Tottori University
2020-2025
Kogakuin University
2013
ABSTRACT Objective We evaluated the long‐term outcomes in health‐related quality of life (QOL) after robot‐assisted radical prostatectomy (RARP) and factors influencing them. Methods Overall, 246 patients who underwent RARP were included. The Expanded Prostate Cancer Index Composite (EPIC) Short Form‐8 (SF‐8) questionnaires utilized. Continence was defined as a score ≤ 1 on question International Consultation Incontinence Questionnaire‐Short Form. Questionnaires collected preoperatively...
To evaluate and compare the survivals radiotherapy-induced adverse events (AEs) of intensity-modulated radiotherapy (IMRT) with androgen deprivation therapy (ADT) trimodality therapy, including low-dose iodine-125 brachytherapy, external beam radiotherapy, ADT, for high-risk localized prostate cancer (LPC). High-risk patients LPC at T stage ≥ 3a, Gleason score 8, initial prostate-specific antigen 20.0 ng/mL treated between 2010 2021 were retrospectively evaluated. All IMRT plus ADT or...
Abstract Objective To evaluate the real-world clinical usage and effectiveness of apalutamide in men with nonmetastatic castration-resistant prostate cancer (nmCRPC). Methods We retrospectively reviewed data 186 who received across 17 institutions. The primary outcomes were for nmCRPC: prior other androgen receptor signaling inhibitors (ARSIs), radical treatment, distribution prostate-specific antigen (PSA) doubling time (PSA-DT) at initial administration apalutamide. secondary efficacy...
725 Background: First-line chemotherapy with 4-6 cycles followed by avelumab 1L maintenance therapy is the standard of care in patients metastatic urothelial carcinoma (mUC). However, a non-negligible number received less than four due to adverse events, or pre-existing severe comorbidities our daily practice. Thus, we examined prognostic impact first-line mUC treated avelumab. Methods: In this multi-institutional study, collected data 91 who following 1 st -line chemotherapy. Patients were...
Few studies have verified the relationship between treatment outcomes of robot-assisted radical cystectomy (RARC) and laparoscopic (LRC). This study aimed to compare perioperative oncologic RARC LRC. Medical records 75 patients (45 30 LRC) who underwent standard or higher lymph node dissection April 2013 December 2019 at Tottori University other satellite hospitals were reviewed. The operative time was shorter in LRC group. Mean estimated blood loss lower No differences noted complication...
Aim The Geriatric 8 (G8) screening tool consists of eight questions and is widely used to assess geriatric frailty. This study aimed compare laparoscopic radical nephroureterectomy outcomes in patients aged >70 years with high low G8 scores. Materials methods Patients who underwent at a single center between 2017 2022 were included this study. Patient background perioperative evaluated two groups: (<14) (≥14). effects age body mass index (BMI) assessed using logistic regression models...
Bladder cancer is a leading cause of cancer-related mortality worldwide, partly due to the absence reliable biomarkers for accurate prediction patient prognosis. Amphoterin-induced gene and open reading frame 2 (AMIGO2) expression prognostic factor in several types cancer. The present study aimed clarify whether AMIGO2 can predict prognosis patients with bladder This retrospective included primary who underwent radical cystectomy at Tottori University Hospital (Yonago, Japan) its affiliated...
Abstract Background Japanese men receiving apalutamide often experience skin-adverse events (AEs), possibly requiring treatment interruption or dose reduction. However, concerns have arisen regarding the impact of these adjustments on efficacy apalutamide. Our study evaluated efficacy, safety, and persistence in with metastatic castration-sensitive prostate cancer (mCSPC). Methods We retrospectively reviewed medical records 108 mCSPC from 14 institutions. The primary outcomes were...
This study aimed to investigate the response platinum-based chemotherapy rechallenge in patients with pembrolizumab-refractory urothelial carcinoma.We retrospectively reviewed 14 carcinoma. Each patient received a regimen that they had not previously (paclitaxel plus carboplatin 10, gemcitabine docetaxel and four). Tumor adverse events were assessed. We evaluated overall survival from start date until death.The median was 11.2 months. The disease-control rate 85.7%. Partial responses...
Abstract Background Multiparametric MRI (mpMRI) is widely used for the diagnosis, surveillance, and staging of prostate cancer. However, it has several limitations, including higher costs, longer examination times, use gadolinium-based contrast agents. This study aimed to investigate accuracy preoperatively assessed index tumors (ITs) using biparametric (bpMRI)/transrectal ultrasound (TRUS) fusion biopsy compared with radical prostatectomy (RP) specimens. Methods We included 113 patients...
The aim of this study was to investigate the longitudinal 5-year long-term outcomes for urinary continence and quality life (QOL) after robot-assisted radical prostatectomy (RARP), particularly nerve-sparing.Among patients who underwent RARP between October 2010 2015, postoperative symptoms were retrospectively examined using International Prostate Symptom Score (IPSS), Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), QOL index, number pads used. Patients divided into...
Background Robotic-assisted radical cystectomy (RARC) is a well-known standard procedure for muscle-invasive bladder cancer. However, it remains controversial whether extracorporeal urinary diversion (ECUD) or intracorporeal (ICUD) superior in this technique. We have developed HYBRID method that combines ECUD and ICUD to retain the advantages of each. The purpose study was compare perioperative outcomes between RARC evaluate usefulness method.
Objectives To investigate preoperative patient factors that may predict the occurrence of perioperative complications following robot‐assisted radical cystectomy at a single center in Japan. Methods From 2013 to 2022, 103 patients underwent RARC our institution. Complications within 90 days after surgery were assessed using Clavien–Dindo classification. Preoperative characteristics and surgical outcomes compared between cohorts with without ≥grade 3. Logistic regression analysis was used...
Postoperative urinary incontinence (UI) after robot-assisted radical prostatectomy (RARP) has a significant impact on patients' quality of life (QOL). Several surgical techniques have been reported to improve postoperative UI. The aim the study was investigate advanced reconstruction vesicourethral support (ARVUS) symptoms and QOL non-nerve-sparing (RARP).Patients who underwent RARP from October 2010 2020 at Division Urology, Department Surgery, Tottori University Faculty Medicine were...
We present a novel and facile approach for preparing monodispersed liposomes simply by permeating lipid–alcohol solutions through Shirasu porous glass (SPG) membranes. This method uses the phenomenon of mixing two miscible liquids at their interface formed near an SPG membrane surface, which induces spontaneous formation liposomes. The effects lipid concentration, pore size membrane, alcohol used solution on structures properties are studied. liposome is around 120 nm, distribution narrow,...
We sought to evaluate the incidence and extent of orgasmic dysfunction in patients after robot-assisted radical prostatectomy identify factors that could predict at risk.A single-center, questionnaire-based, cross-sectional study was conducted on who underwent (n = 523) between October 2010 November 2019. In addition six questions about sexual activity, function, altered perception orgasms, dysorgasmia, climacturia, International Consultation Incontinence Questionnaire Short Form...
There are few reports confirming the relationship between therapeutic effects of adjuvant systemic chemotherapy and intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma. We aimed to evaluate benefits on carcinoma.We retrospectively reviewed medical records 133 patients with pathological T stage ≥3 carcinoma or lymph node metastasis who underwent January 2010 September 2020 at our hospital other satellite hospitals. In total, 60 received...
Abstract Background This study aimed to evaluate rectal pain and bowel function of the patients following robot‐assisted radical prostatectomy (RARP). Methods We divided 296 who underwent RARP into two groups depending on intervention: NS (nerve‐sparing) group (bilateral NS, unilateral bilateral partial NS) non‐NS (unilateral non‐NS). Bowel was assessed using Extended Prostate Cancer Index Composite for 24 months after RARP. Results The score urgency at 1−6 were more significantly impaired...
Abstract Frequent loss of heterozygosity (LOH) on the short arm human chromosome 3 (3p) region has been found in pancreatic cancer (PC), which suggests likely presence tumor suppressor genes this region. However, functional significance LOH development PC not clearly defined. The telomerase reverse transcriptase gene ( hTERT) contributes to unlimited proliferative and tumorigenicity malignant tumors. We previously demonstrated that hTERT expression was suppressed by introduction several cell...
Objective To investigate the involvement of pretreatment C‐reactive protein (CRP) and neutrophil‐to‐lymphocyte ratio (NLR) in prognosis patients who underwent intravesical bacillus Calmette‐Guérin (BCG) therapy for non‐muscle invasive bladder cancer (NMIBC). Methods The clinicopathological data 1709 with NMIBC initial BCG after transurethral resection tumor were retrospectively analyzed to evaluate outcome a multicenter study conducted by Japan Urological Oncology Group. prognoses these...