A5038206081- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Renal and related cancers
- Surgical site infection prevention
- Renal Transplantation Outcomes and Treatments
- GDF15 and Related Biomarkers
- Pediatric Urology and Nephrology Studies
- Pelvic floor disorders treatments
- Polyamine Metabolism and Applications
- Ureteral procedures and complications
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Cancer Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Photodynamic Therapy Research Studies
Kagawa University
2016-2025
Kagawa University Hospital
2019-2025
The University of Texas MD Anderson Cancer Center
2015-2017
Hyogo Medical University
2013-2014
Kurashiki Central Hospital
2010-2014
Université Paris-Est Créteil
2007
Objectives To examine prostate cancer staging in real‐world clinical practice. Methods We retrospectively analyzed 698 patients referred to the Department of Urology at Kagawa University Hospital from 25 facilities for treatment June 2014 December 2023. Patients treated with dutasteride ( n = 10) and who underwent our institution 197) were excluded. The outcomes interest proportion computed tomography bone scintigraphy, diagnostic rates metastasis stratified by D'Amico risk, incidental...
Abstract These guidelines cover a wide range of topics from prostate cancer epidemiology to palliative care. Questions arising in daily clinical practice have been extracted and formulated as questions. In the 4 years since previous edition, there major changes – for example, robot‐assisted prostatectomy has rapidly come into widespread use, new hormones anticancer drugs developed castration‐resistant cancer. response these developments, number fields included this guideline was increased 11...
The use of immune checkpoint inhibitors to treat urothelial carcinoma (UC) is increasing rapidly without clear guidance for validated risk stratification. This multicenter retrospective study collected clinicopathological information on 463 patients, and 11 predefined variables were analyzed develop a multivariate model predicting overall survival (OS). was using an independent dataset 292 patients. Patient characteristics outcomes well balanced between the discovery validation cohorts,...
Objective To examine the association between substaging and outcomes following radical cystectomy (RC) in patients with stage III bladder cancer. Methods We conducted a retrospective observational study using nationwide data from Japan, including 708 cancer who underwent RC. Substaging was based on American Joint Committee Cancer's 8th edition. pT3‐4aN0 pTanyN1 were newly defined as IIIA, while pTanyN2‐3 IIIB. Baseline covariates balanced inverse probability of treatment weighting. analyzed...
EPCA, a nuclear matrix protein, has been identified as novel prostate cancer marker through protein profiling analyses comparing and its normal counterpart. A recent study of biopsy specimens revealed that EPCA stained positive in the negative cores individuals with at later biopsy. We clarified relationship between expression clinicopathological parameters, including grade stage. Morphological characteristics cells noncancerous tissues were also analyzed.Prostate tissue obtained from 50...
The Paris System (TPS) for reporting urinary cytology differs from conventional systems (CS) in that it focuses on the diagnosis of high-grade urothelial carcinoma (HGUC). This study investigated impact TPS implementation diagnostic accuracy HGUC by comparing with our institutional CS.
To assess the impact of histological variants on survival and response to treatment with pembrolizumab in patients chemo-resistant urothelial carcinoma (UC).The medical records 755 advanced UC who received were reviewed retrospectively. Patients classified into pure (PUC) each variant. Best overall (BOR) (OS) compared between groups using a propensity score matching (PSM).Overall, 147 (19.5%) harboured any variant (VUC). After PSM, there no significant differences objective rate (ORR, 24.5%...
5-aminolevulinic acid is a protoporphyrin IX precursor used for photodynamic diagnosis. We aimed to clarify the therapeutic benefits of orally administered diagnosis in transurethral resection non-muscle-invasive bladder cancer real-world setting. From January 2009 December 2020, patients with who have undergone visually complete by initial surgery were included. Histopathologically confirmed residual and intravesical recurrent was retrospectively investigated compared using conventional...
The objective of this study is to validate the predictive ability 2021 European Association Urology (EAU) risk model compared that existing models, including 2019 EAU and scoring tables Organization for Research Treatment Cancer, Club Urologico Espanol de Tratamiento Oncologico, Japanese Nishinihon Uro-oncology Extensive Collaboration Group. This retrospective multi-institutional database included two cohorts-3024 patients receiving intravesical bacillus Calmette-Guerin (BCG) treatment (BCG...
Current methods used to determine pathological examination of the lymphatics after radical cystectomy are tedious and costly. We performed a systemic study uroplakin II (UP II) cytokeratin 20 (CK 20) expression in pelvic lymph nodes on multiple sides patients with bladder cancer.A total 82 node 19 tumor samples were obtained from 21 cancer by lymphadenectomy for reverse transcriptase-polymerase chain reaction assay.Of tissue specimens (100%) 13 (68.4%) positive UP CK mRNA expression,...
To explore possible solutions to overcome chronic Bacillus Calmette-Guérin (BCG) shortage affecting seriously the management of non-muscle invasive bladder cancer (NMIBC) in Europe and throughout world, we investigated whether non-maintenance eight-dose induction BCG (iBCG) was comparable six-dose iBCG plus maintenance (mBCG).This observational study evaluated 2669 patients with high- or highest-risk NMIBC who treated without mBCG during 2000-2019. The were classified into five groups...
This analysis utilized a subject-based of data from the prospective single-arm phase III trial (jRCT2061210055) to evaluate efficacy photodynamic diagnosis (PDD) when 5-aminolevulinic acid hydrochloride (5-ALA) was administered 4-8 h before transurethral resection bladder tumors (TURBT). study evaluated 144 patients suspected having non-muscle invasive cancer (NMIBC), including 127 with NMIBC (38 had normal-to-flat-appearing cancer) and 17 without cancer. The diagnostic accuracy clinical...
Background/Objectives: The objective of this study was to evaluate the oncological outcomes and safety nerve-sparing (NS) robot-assisted radical prostatectomy (RARP) when applied without Prostate Imaging-Reporting Data System (PI-RADS) ≥3 lesions or Gleason pattern ≥4 on biopsy in peripheral zone (PZ). Methods: We retrospectively analyzed 208 patients who underwent RARP between August 2017 December 2022, excluding those had received preoperative hormonal therapy. After NS status...
ABSTRACT Objective To evaluate the effects of number neoadjuvant chemotherapy (NAC) cycles and addition adjuvant (AC) after NAC on overall survival (OS) patients with muscle‐invasive bladder cancer (MIBC). Patients Methods We retrospectively evaluated 1687 cT2‐4NxM0 MIBC who received radical cystectomy (RC) alone or RC plus perioperative at 36 institutions within Japanese Urological Oncology Group. effect (2 vs. ≥ 3 cycles) AC OS. Results Among analyzed, 946 a median three cycles. The...
ABSTRACT Introduction Hemophagocytic lymphohistiocytosis (HLH) is characterized by macrophage and cytotoxic lymphocyte hyperactivation, fever, pancytopenia, liver dysfunction, abnormal coagulation. However, no specific treatments have been established for HLH caused immune checkpoint inhibitors. Case Presentation A 63‐year‐old male with clear cell renal carcinoma was treated pembrolizumab lenvatinib. Fifteen days later, he developed impairments, hypofibrinogenemia, hypertriglyceridemia,...
D-allose is a rare sugar that has been reported to up-regulate thioredoxin-interacting protein (TXNIP) expression and affect the production of intracellular reactive oxygen species (ROS). However, antitumor effect unknown. This study aimed determine whether orally administered could be candidate drug against bladder cancer (BC). To this end, BC cell lines were treated with varying concentrations (10, 25, 50 mM). Cell viability ROS levels assessed using assay flow cytometry. TXNIP was...
To analyse the impact of histological discordance subtypes (subtypes or divergent differentiation [DD]) in specimens from transurethral resection (TUR) and radical cystectomy (RC) on outcome patients with bladder cancer receiving RC.