A5027823578- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Peripheral Artery Disease Management
- Circular RNAs in diseases
- Machine Learning in Healthcare
- Aortic Disease and Treatment Approaches
- MicroRNA in disease regulation
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Neurological Disorders and Treatments
- Cancer-related gene regulation
- Vaccine Coverage and Hesitancy
- Coronary Interventions and Diagnostics
- Amyotrophic Lateral Sclerosis Research
- Dementia and Cognitive Impairment Research
- Vascular Malformations Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Viral Infections and Outbreaks Research
- Photoacoustic and Ultrasonic Imaging
Beijing Tian Tan Hospital
2020-2025
Capital Medical University
2015-2025
National Clinical Research Center for Digestive Diseases
2020-2025
Chinese Institute for Brain Research
2017-2024
Janssen (Netherlands)
2023
Beijing Obstetrics and Gynecology Hospital
2015
Ajou University
2008
Abstract Background Peroxiredoxin 2 (Prx2), an intracellular protein that regulates redox reactions, released from red blood cells is involved in inflammatory brain injury after intracerebral hemorrhage (ICH). Toll‐like receptor 4 (TLR4) may be crucial this process. This study investigated the role of Prx2‐TLR4 axis following experimental ICH mice. Methods First, C57BL/6 mice received intracaudate injection autologous arterial or saline and their brains were harvested on day 1 to measure...
<b>BACKGROUND AND PURPOSE:</b> CT perfusion is a much more readily accessible imaging method to assess cerebral hemodynamic status than single-photon emission CT. We prospectively assessed quantitative cerebrovascular reserve by using acetazolamide (ACZ)-challenged for evaluating impairment in ischemic adult Moyamoya disease and compared it with angiographic findings. <b>MATERIALS METHODS:</b> Sixteen patients 12 age-matched normal control subjects underwent both ACZ-challenged digital...
The outcome of deploying balloon-mounted stents for symptomatic intracranial atherosclerotic stenosis (ICAS) has not been fully investigated. In this study we evaluate the safety and long-term using to treat ICAS in comparison with WEAVE/WOVEN study. a multicenter registry stenting artery China, 159 patients treated an stent approved by China Food Drug Administration were evaluated. morphological features lesions categorized Mori classification. endpoints, including periprocedural clinical...
To study the relationship between elevated C-reactive protein (CRP) levels, infection, and spontaneous intracerebral hemorrhage (ICH) outcomes. Patients were classified into four groups (Q1-Q4). Logistic regression was used to analyze different CRP levels functional disability (mRS score of 3-5) at discharge, hematoma evacuation, in-hospital mortality. Subgroup analysis conducted on patients with or without infection during hospitalization. A total 14,529 ICH enrolled in this study. In...
This study aimed to identify predictors of intracranial in-stent restenosis (ISR) after stent placement in symptomatic atherosclerotic stenosis (ICAS).The authors retrospectively collected data from consecutive patients who suffered ICAS and underwent successful Beijing Tiantan hospital. Eligible were classified into "ISR," "indeterminate ISR," or "no-ISR" groups by follow-up digital subtraction angiography CT angiography. A multivariate logistic regression model was used explore the ISR...
Abstract In this study, we aimed to disclose the association of pre- and post-stroke glycemic status with clinical outcome in patients spontaneous intracerebral hemorrhage (sICH). It was a multicenter, prospective, observational cohort conducted 13 hospitals Beijing from January 2014 September 2016. The admission random blood glucose (RBG), fasting (FBG) hemoglobin A1c (HbA1c) at 90 days after sICH onset were analyzed comprehensively. Poor defined as death or modified Rankin Scale (mRS)...
Background and purpose In-stent restenosis (ISR) is one of the long-term adverse outcomes endovascular angioplasty stenting for symptomatic intracranial arterial stenosis. In this study, we try to evaluate safety efficacy treatment ISR. Methods We retrospectively collected patients with ISR who underwent from June 2012 August 2019 at a high-volume stroke center. Successful recanalization was defined as ≤30% residual Stroke, myocardial infarction, death after within 30 days were used...
Background and purpose Both the magnitude cumulative exposure of atherogenic lipoproteins have an impact on atherosclerosis risk, exploration focus has shifted from one single lipoprotein assessment to lipoproteins. We aim investigate relationship between different lipid parameters risk newly developed carotid plaque in this study. Methods In Asymptomatic Polyvascular Abnormalities Community study, 2947 participants were included with follow-up every 2 years 2006 2012. Lipid including total...
Background and Purpose: The Enterprise stent has been used for treating intracranial atherosclerotic stenosis (ICAS), but its long-term outcome remains unclear. purpose of this study was to evaluate the clinical efficacy patients with symptomatic ICAS due hypoperfusion. Method: Patients hypoperfusion treated stents from a high-volume stroke center were evaluated. successful recanalization defined as Modified Thrombolysis In Cerebral Infarction (mTICI) ≥ 2b. neurological death that occurred...
Objective: To explore the cerebral hemodynamic changes after revascularization in patients with hemorrhagic moyamoya disease (MMD). Materials and Methods: We retrospectively included 57 MMD a high-volume stroke center from January 2016 to December 2018. All subjects were evaluated whole-brain CT perfusion (CTP) before surgical revascularization. Absolute relative CTP values regions of cortical middle artery territory (CMT) deep brain area (DBA) hemispheres measured. Differences between pre-...
Background and Purpose: Our aim was to investigate the frequency of dehydration at admission associations with in-hospital mortality in patients intracerebral hemorrhage (ICH). Methods: Data consecutive ICH between August 2015 July 2019 from China Stroke Center Alliance (CSCA) registry were analyzed. The stratified based on blood urea nitrogen (BUN) creatinine (CR) ratio (BUN/CR) into dehydrated (BUN/CR ≥ 15) or non-dehydrated &lt; groups. analyzed multivariate logistic regression models...
The surface regularity index (SRI) reflects hematoma in patients with intracerebral hemorrhage (ICH). Studies had reported an association between irregularity and expansion (HE). However, research on the correlation SRI clinical outcomes ICH following minimally invasive surgery (MIS) is limited. This study aimed to investigate ability of predict rebleeding poor drainage spontaneous MIS.
Abstract The incidence of intracerebral hemorrhage (ICH) is increasing every year, with very high rates mortality and disability. prognosis elderly ICH patients extremely unfavorable. Interleukin, as an important participant in building the inflammatory microenvironment central nervous system after ICH, has long been focus neuroimmunology research. However, there are no studies on role IL31 play pathologic process ICH. We collected para‐lesion tissue for immunofluorescence flow cytometry...
Background: Headache associated with Moyamoya disease (HAMD) in the Chinese population is not well-described. The long-term outcome of surgical revascularization and natural course HAMD has been disclosed either. Methods: A headache screening questionnaire China based on ICHD2 a face-to-face interview performed by an experienced neurologist were used to investigate characteristics frequency pain intensity 3 months before admission, telephone was for follow-up large cohort 119 patients HAMD....
Abstract Background Intracerebral hemorrhage (ICH) has a high mortality and morbidity in the world. Elevated blood pressure (BP) heart rate (HR) have been identified as independent risk factors, with potential to predict prognosis recurrence of cardiovascular diseases. Our study aimed elucidate association between BP HR levels severity, well prognosis, patients diagnosed ICH. Methods The basic characteristics laboratory examination results, inclusive upon admission, were recorded baseline...
We elucidated the clinical and radiological characteristics analyzed risk factors for hemorrhage poor outcomes of cerebral venous malformations (CVMs) in a northern Chinese population.We included 60 consecutive patients with CVM Beijing Tiantan Hospital from January 2011 to February 2018. The manifestations, characteristics, management, were analyzed. followed up 5-64 months (median, 26). Poor repeat bleeding, secondary infarction, severe disability (modified Rankin scale score ≥3),...
Objective: To evaluate clinical and radiological outcomes after revascularization of hemorrhagic moyamoya disease (MMD). Materials Methods: We retrospectively collected patients with MMD who received from January 2011 to June 2018 at a high-volume stroke center. Rebleeding, ischemic stroke, modified Rankin Scale (mRS) death were used long-term outcome. Poor neurological outcome was defined as mRS>2. The changes original collaterals between different surgical compared. Results: A total 312...
Cytotoxic edema (CE) is an important form of perihematomal (PHE), which a surrogate marker secondary injury after intracerebral hemorrhage (ICH). However, knowledge about CE ICH insufficient. Whether has adverse effects on clinical outcomes patients with remains unknown. Therefore, we aimed to investigate the temporal pattern and its association in ICH.Data were derived from randomized controlled study (comparing deproteinized calf blood extract placebo ICH). Intervention this original did...
Background and Purpose: Intracranial atherosclerosis has gained increasing attention due to the high risk of recurrent clinical or subclinical ischemic events, while relationship between low-density lipoprotein cholesterol (LDL-C) measured at a single time point intracranial atherosclerotic stenosis (ICAS) is inconsistent. This study aims assess association cumulative exposure increased LDL-C prevalence asymptomatic ICAS. Methods: The Asymptomatic Polyvascular Abnormalities Community was...
Chronic carotid artery occlusion remains a poorly understood risk factor for subsequent stroke, and potential revascularization is dependent on understanding the anatomy nature of occlusion. Luminal imaging cannot assess an occlusion, so internal structure must be inferred. The present study examines signal characteristics symptomatic asymptomatic that may point to management differentiation. We prospectively recruited patients who were diagnosed with chronic defined as longer than 4 weeks...