A5101780798- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Sirtuins and Resveratrol in Medicine
- Mitochondrial Function and Pathology
- Atrial Fibrillation Management and Outcomes
- Curcumin's Biomedical Applications
- Computational Drug Discovery Methods
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurotransmitter Receptor Influence on Behavior
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Genetic Neurodegenerative Diseases
- Nerve injury and regeneration
- Calcium signaling and nucleotide metabolism
- Restless Legs Syndrome Research
- Receptor Mechanisms and Signaling
- Venous Thromboembolism Diagnosis and Management
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Intensive Care Unit Cognitive Disorders
- Adenosine and Purinergic Signaling
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
University of Oslo
2020-2021
Akershus University Hospital
2020-2021
Anhui Medical University
2020
Anhui Mental Health Center
2020
First Affiliated Hospital of Anhui Medical University
2020
Spinal Research
2020
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2019-2020
XinHua Hospital
2015-2017
Abstract A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer’s disease (AD). Strategies for treating impaired mitophagy would benefit from the identification modulators. Here we report combined use unsupervised machine learning (involving vector representations molecular structures, pharmacophore fingerprinting conformer fingerprinting) a cross-species approach screening experimental validation new...
Mounting evidence suggests that mitochondrial dysfunction and impaired mitophagy lead to Parkinson's disease (PD). Quercetin, one of the most abundant polyphenolic flavonoids, displays many health-promoting biological effects in diseases. We explored neuroprotective effect quercetin vivo 6-hydroxydopamine (6-OHDA)-lesioned rat model PD vitro 6-OHDA-treated PC12 cells. In vitro, we found (20 μM) treatment improved quality control, reduced oxidative stress, increased levels markers PINK1...
Random-pattern skin flaps are widely used to close defects in reconstructive and plastic surgeries; however, they vulnerable necrosis, particularly the distal portion of flap.Here, we examined effects metformin on flap survival mechanisms underlying these effects.Following treatment, area, blood flow, number microvessels present were increased postoperative day 7, whereas tissue edema was reduced.In addition, promoted angiogenesis, inhibited apoptosis, relieved oxidative stress, autophagy...
The exact mechanisms of PD are unclear, but Parkin-mediated mitophagy dysfunction is believed to play a key role. We investigated whether blood levels Parkin and other biomarkers linked the risk developing PD. Baseline measures biomarkers, including Homocysteine, carcinoembryonic antigen, Urea, total proteins, cholesterol, creatine kinase, albumin, were collected from 197 clinically diagnosed Parkinson's disease participants 107 age-matched healthy controls in Wenzhou Biomarkers Living...
Delirium is an acute fluctuating impairment of attention and awareness, common in ischemic stroke (AIS). This study aimed to evaluate the prognostic significance delirium for neurological function at 3 months post-stroke, develop a predictive model integrating biomarkers enhance accuracy. We conducted prospective cohort patients admitted unit (n=722). All were screened daily during clinical care. Plasma measured within 24 hours after admission. The main outcomes evaluated with 3-months...
The ATN's different modalities (fluids and neuroimaging) for each of the Aβ (A), tau (T), neurodegeneration (N) elements are used biological diagnosis Alzheimer's disease (AD). We aim to identify which ATN category achieves highest potential predictive accuracy longitudinal cognitive decline.
Several lines of evidence point to alteration in brain metabolic homeostasis Parkinson's disease (PD) and levodopa-induced dyskinesia (LID), yet the mechanism different regions underlying PD LID remains largely unknown. The present study aimed uncover pathways across anatomical LID. Using an NMR-based metabolomic approach, we generated metabolomics profiling data from six rats following onset LIDs. diversity metabolite patterns its relation were further investigated through principal...
Introduction To explore the combined diagnostic value of plasma Lewy body-associated proteins (p-Asyn at ser129, total α-syn, and oligomeric α-syn) for diagnosis PD versus healthy controls (HCs) other syndromes (PDs), as well clinical characteristics prediction. Methods This study included 145 participants: 79 patients with PD, 24 PDs, 42 HCs. A panel levels p-Asyn, α-syn was measured by enzyme-linked immunosorbent assay (ELISA). The primary outcome discriminative accuracy three biomarkers...
Levodopa (L‑DOPA) is the gold standard for symptomatic treatment of Parkinson's disease (PD); however, long‑term therapy associated with emergence L‑DOPA‑induced dyskinesia (LID). Nigral dopaminergic cell loss determines degree drug exposure and time required initial onset LID. Accumulating evidence indicates that α‑lipoic acid (ALA) decreases this nigral loss. However, until now, precise mechanisms ALA have only been partially understood in Chronic L‑DOPA was demonstrated to develop intense...
Abstract Extensive studies indicate that mitochondria dysfunction is pivotal for Alzheimer’s disease (AD) pathogenesis; while cumulative evidence suggests increased mitochondrial stress response (MSR) may mitigate neurodegeneration in AD, explorations to develop a MSR-targeted therapeutic strategy against AD are scarce. We combined cell biology, molecular and pharmacological approaches unravel novel pathway by which NAD + -boosting agent nicotinamide mononucleotide (NMN) regulates MSR...