A5078811167- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Veterinary medicine and infectious diseases
- Celiac Disease Research and Management
- Microbial Metabolites in Food Biotechnology
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Soft tissue tumor case studies
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Phytochemistry and Bioactive Compounds
- Respiratory and Cough-Related Research
- Diabetes and associated disorders
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
St. Vincentius-Kliniken
2007-2020
Karlsruhe University of Education
2011
Friedrich-Alexander-Universität Erlangen-Nürnberg
1997-2006
Institut für Psychogerontologie
1998-2006
Massachusetts General Hospital
2004
University of Bonn
2002
Institute of Medical Microbiology and Hygiene
2001
University of Lübeck
2001
Technische Universität Dresden
1999
Max Planck Society
1999
In this study, we isolated and characterized a chromosomal locus of Helicobacter pylori previously identified by transposon shuttle mutagenesis as being involved in the adhesion pathogen to gastric epithelial cells. Two closely homologous genes were identified, designated alpA alpB, encoding outer membrane (OM) proteins 518 amino acids each. They are members protein supergene family H. 26695 complete genome sequence. AlpA carries functional lipoprotein signal AlpB putative standard...
Association studies have implicated the glycosaminoglycan hyaluronan (hyaluronic acid, HA) and its degrading enzymes hyaluronidases in tumour progression metastasis. Oligosaccharides of degraded HA been ascribed a number biological functions that are not exerted by high-molecular-weight (HMW-HA). However, whether these small oligosaccharides (sHA) role currently remains uncertain due to an inability analyse their concentration tumours. We report novel method determine sHA ranging from 6 25...
In Asian medicine the fruit of okra plant, Abelmoschus esculentus (L.) Moench., is used as a mucilaginous food additive against gastric irritative and inflammative diseases. To find rational basis for its use these diseases, several crude purified carbohydrate-containing fractions from immature fruits were isolated analyzed, their effects Helicobacter pylori in an situ adhesion model on sections human mucosa determined. Pretreatment bacteria with fresh juice preparation inhibited bacterial...
ABSTRACT In this study, cytokine patterns produced by CD4 + T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori -positive gastritis were compared. To end, expression intracellular cytokines (interleukin-4 [IL-4] and gamma interferon) was assessed flow cytometry. Ten to 60% the interferon upon stimulation. With exception one patient, IL-4-positive not detected. Therefore, infiltrating stomach mucosa during H. infection show a Th1 phenotype....
Background and Purpose — Helicobacter pylori Chlamydia pneumoniae have been associated epidemiologically pathogenetically with coronary atherosclerosis. However, population-based data on chronic infection stroke are lacking. Therefore, we investigated the association of both bacterial pathogens ischemic subtypes in a case-control study. Methods Patients first Erlangen Stroke Project were collected as cases. Neighborhood controls drawn from study population, matched for age, sex, place...
Background —It has recently been shown that humoral antigastric autoreactivities occur in a substantial number of Helicobacter pylori infected patients. Aims— To analyse the relevance such autoantibodies for histological and serological parameters infection as well clinical course. Methods —Gastric biopsy samples sera from 126 patients with upper abdominal complaints were investigated evidence H using histology serology. Autoantibodies against epitopes human gastric mucosa detected by...
Abstract The homeobox transcription factor Cdx2 specifies intestinal development and homeostasis is considered a tumor suppressor in colorectal carcinogenesis. However, mutations are rarely found. Invasion of cancer characterized by transient loss differentiation nuclear accumulation the oncoprotein β-catenin budding cells. Strikingly, this reversed growing metastases, indicating that progression dynamic process not only driven genetic alterations but also regulated environment. Here we...
Helicobacter pylori NCTC11637 expresses a lipopolysaccharide (LPS) that comprises an O antigen side‐chain with structural homology to the human blood group Lewis X (Le x ). The role of this molecule in adhesion H. gastric epithelial cells was investigated. Mutants expressing truncated LPS structures were generated through insertional mutagenesis rfbM and galE; genes encode GDP mannose pyrophosphorylase galactose epimerase respectively. Compositional analysis revealed galE mutant expressed...
Receptor tyrosine kinases (RTKs) are in the focus of targeted therapy for epithelial tumors. Our study addressed role EGFR, HER2 and HER3 expression dimerization esophageal cancers situ vitro context therapeutic EGFR inhibitors. In archival pretreatment biopsies carcinomas ( n = 110), was preferentially expressed squamous cell (ESCCs) (22.4%; p 0.088) (34.4%; < 0.001) with (91.5%; (Barrett's) adenocarcinomas (EACs). proximity ligation assays revealed mainly homodimers ESCC EAC cases,...
Prostate cancer (CaP) is one of the most common neoplasms in USA and Europe. We used differential display PCR (DD-PCR) to identify genes related development prostate cancer.The RNA 4 patients with untreated CaP was analyzed for differentially expressed genes. Using DD-PCR, we identified a downregulated cDNA-fragment these cells. This fragment (N7) cloned further by CMRT-PCR, Northern-blot analysis, situ hybridization.Sequence analysis revealed that N7 identical 3'-untranslated region...
Background: Maintenance of gastric mucosal integrity depends on the balance between cell loss due to apoptosis and proliferation. Helicobacter pylori induces in epithelial cells, but regulation this process has been little studied. The Bcl-2 proteins are best-studied family involved mechanism apoptotic death. Some members family, such as Bcl-2, inhibit apoptosis, whereas others, Bax, induce it. present study was performed determine rate mRNA protein expression for Bax mucosa duodenal ulcer...
The gram-negative bacterial pathogen Helicobacter pylori is a major cause of peptic ulcer disease and risk factor for gastric cancer in humans. Adapted H. strains, such as strain SS1, are able to infect mice useful model colonization vaccination studies. In this study we used streptomycin-resistant derivative SS1 analyze the behavior success wild-type (wt) various knockout BALB/c C57BL/6J genetic backgrounds. We here report that interleukin-4 (IL-4(-/-)) weakly overcolonized compared wt but...
Several crude and purified polysaccharides from black currant seeds (Ribes nigrum L.) have been isolated, analysed examined on their effects against Helicobacter pylori in situ adhesion studies sections of human gastric mucosa. After pre-treatment with 0.01 to 0.1 % solutions the isolated raw polysaccharide (RPS), epithelial binding bacteria was considerably reduced a concentration-dependent manner, as compared non-treated control suspension. Preincubation mucosal did not result bacteria. An...