A5018797184- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Inflammasome and immune disorders
- Gastrointestinal motility and disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Dysphagia Assessment and Management
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cystic Fibrosis Research Advances
- Gastric Cancer Management and Outcomes
- Autoimmune and Inflammatory Disorders
- Health and Medical Research Impacts
- Biomedical and Engineering Education
- COVID-19 Clinical Research Studies
- Diverticular Disease and Complications
- Immune Response and Inflammation
- Neuroendocrine Tumor Research Advances
Morehouse School of Medicine
2021-2025
University of Arkansas for Medical Sciences
2015-2021
Central Arkansas Veterans Healthcare System
2015-2019
University of Alberta Hospital
2007-2014
Alberta Hospital Edmonton
2007-2014
University of Alberta
2009-2013
Brigham and Women's Hospital
2002-2010
Harvard University
1998-2010
University Gastroenterology
2010
Northwestern University
2005
To identify prognostic factors in methanol poisoning and determine the effect of medical interventions on clinical outcome.Retrospective review all patients treated for from 1982 through 1992 at The Toronto Hospital. Presenting history, physical examination, results laboratory tests, interventions, final outcomes after hemodialysis were abstracted.Of 50 poisoning, 18 (36%) died, 32 (64%) survived. Seven survivors sustained visual sequelae (22%), remaining 25 (78%) recovered completely....
Confocal endomicroscopy can be used to image intestinal mucosa. Epithelial gaps resulting from shedding of epithelial cells have been reported in patients. We hypothesize that the rate cell increases patients with Crohn's disease, leading more and barrier dysfunction. In this study, we probe-based confocal laser quantify disease compared controls. also determined density a mouse model inflammatory bowel disease-interleukin-10-deficient (IL-10) mice, versus background strain using rigid probe...
INTRODUCTION: Duodenal epithelial barrier impairment and immune activation may play a role in the pathogenesis of functional dyspepsia (FD). This study was aimed to evaluate duodenal epithelium patients with FD healthy individuals for detectable microscopic structural abnormalities. METHODS: is prospective using esophagogastroduodenoscopy enhanced confocal laser endomicroscopy (CLE) mucosal biopsies (n = 16) controls 18). Blinded CLE images analysis evaluated density gaps (cell extrusion...
Microbial sensing plays essential roles in the innate immune response to pathogens. In particular, NLRP3 forms a multiprotein inflammasome complex responsible for maturation of interleukin (IL)-1β. Our aim was delineate role macrophages, and contribution IL-1β host defense against Citrobacter rodentium acute infection mice. Nlrp3−/− background C57BL/6 (WT) mice were infected by orogastric gavage, received (0.5 µg/mouse; ip) on 0, 2, 4 days post-infection (DPI), assessed 6 10 DPI. Infected...
OBJECTIVES: Epithelial gaps resulting from intestinal cell extrusions can be visualized with confocal laser endomicroscopy (CLE) during colonoscopy and increased in normal-appearing terminal ileum of inflammatory bowel disease (IBD) patients. Cell-shedding events on CLE were found to predictive relapse. The aim this study was assess the prognostic value epithelial gap densities for major clinical (hospitalization or surgery) follow-up. METHODS: We prospectively followed IBD patients...
Objectives: To assess strategies for optimizing participation of underserved minorities in a blood-based early CRC detection test study (PREEMPT CRC; NCT04369053) at hospital serving primarily Black patients. Methods: Culturally sensitive, racially congruent research staff approached patients undergoing average-risk screening colonoscopy. Consent/study procedures were synchronized with clinical appointments. Enrolled and not-enrolled patient characteristics compared. Recruitment was compared...
Two distinct forms of intestinal epithelial cell (IEC) extrusion are described: 1 with preserved integrity and that introduced breaches in the lining. In this study, we sought to determine mechanism underlying IEC alters permeability gut epithelium.IEC extrusions polarized T84 monolayer were induced nigericin. Epithelial was assessed transepithelial electrical resistance movements latex microspheres green fluorescent protein-transfected Escherichia coli across monolayer. vivo modulated...
Probe-based confocal laser endomicroscopy (pCLE) is a novel imaging modality that enables virtual optical biopsy in vivo. Loss of barrier function the small bowel observed via pCLE as increased density epithelial gaps (extrusion zones left intestinal lining after cells are shed) predictive relapse adult patients with inflammatory disease (IBD). This study aims to determine whether such observations on similarly pediatric IBD.Pediatric biopsy-proven IBD underwent during colonoscopy and...
Abstract Objective Mucosal barrier dysfunction plays a crucial role in intestinal inflammation Crohn’s disease (CD). Intestinal epithelial cell (IEC) death resulting from innate immune activation, termed pyroptosis, was recently found to be cause of this defect. The aim study determine the predictive value pretreatment ileal biopsy pyroptosis as biomarker for clinical response vedolizumab CD. Design patients ranging 18 80 years old 5 IBD centers with pre-vedolizumab biopsies during...
Endoluminal gastroplication (ELGP) is an endoscopic mucosal suturing procedure for the treatment of gastroesophageal reflux disease. The antireflux mechanism suture remains poorly understood. aim this study to investigate any morphologic changes in smooth muscle layer induced by sutures placed at junction.ELGPs were performed using devices with placement two or three circumferential within 2 cm squamocolumnar junction. Eight patients subsequent symptom resolution underwent ultrasound (EUS)...
INTRODUCTION: Proton pump inhibitor (PPI) use was recently reported to be associated with increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and worse clinical outcomes. The underlying mechanism(s) for this association are unclear. METHODS: We performed a prospective study of hospitalized disease 2019 (COVID-19) patients COVID-negative controls understand how PPI may affect angiotensin-converting enzyme (ACE2) expression stool SARS-CoV-2 RNA. Analysis...
Atypical manifestations are common in patients with gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the response atypical GERD endoscopic antireflux treatment.Patients including hoarseness, cough, wheezing, and non-cardiac chest pain were studied. Endoscopic treatment consisted placement sutures below squamo-columnar junction. Clinical defined as complete resolution symptom. Patients followed clinically for up 3 yr after procedure. Short-term evaluated within 6...
BACKGROUND: Wireless pH studies can offer prolonged monitoring, which may potentially facilitate the diagnosis and management of patients with gastroesophageal reflux disease (GERD). The aim present study was to evaluate detection rate abnormal esophageal acid exposure using monitoring in suspected or refractory GERD symptoms. METHODS: Patients undergoing ambulatory for evaluation GERD-related symptoms were assessed. a known tested on medical therapy, while off therapy. wireless capsules...
Therapeutic efficacy of biologics has remained at about 50% for 2 decades. In Crohn's disease (CD) patients, we examined the predictive value an epithelial cell biomarker, ileal microvillar length (MVL), clinical response to ustekinumab (UST) and vedolizumab (VDZ) its relationship another intestinal (IEC) pyroptosis, with respect VDZ.Ileal biopsies from UNITI-2 randomized controlled trial were analyzed MVL as a predictor UST. 5-center academic retrospective cohort CD was determine VDZ....
Crohn's disease (CD) is a chronic inflammatory condition affecting the entire gastrointestinal tract that associated with significant humanistic, clinical, and economic burdens. Few studies have assessed association between CD severity patient-reported outcomes (PROs), healthcare resource utilization (HCRU), medical costs; even fewer examined differences in among patients of various racial/ethnic groups.
OBJECTIVES: Confocal laser endomicroscopy (CLE) is a non-invasive imaging modality of the gastrointestinal tract. Epithelial gaps in small intestine patients and rodents have been demonstrated using CLE. The goal this study was to quantitatively validate findings epithelial gap density observed with CLE against confocal microscopy (CM) light microscopy. METHODS: Two strains mice (control 129 Sv/Ev interleukin 10 knockout (IL-10−/−)) underwent terminal ileum. Adjacent ileal tissues were...