A5077612510- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Thermography and Photoacoustic Techniques
- Soft Robotics and Applications
- Optical Imaging and Spectroscopy Techniques
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Hand Gesture Recognition Systems
- Stroke Rehabilitation and Recovery
- Ultrasound in Clinical Applications
- Surgical Simulation and Training
- Muscle activation and electromyography studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Coherence Tomography Applications
- Ultrasonics and Acoustic Wave Propagation
- Flow Measurement and Analysis
- Advanced Radiotherapy Techniques
- Renal and Vascular Pathologies
- Medical Imaging and Analysis
- Advanced X-ray and CT Imaging
- Robot Manipulation and Learning
- Radiology practices and education
- Computer Graphics and Visualization Techniques
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
Worcester Polytechnic Institute
2019-2025
University of Massachusetts Chan Medical School
2023
Johns Hopkins University
2014-2020
Johns Hopkins Medicine
2018
Kyoto University
2012-2015
Photoacoustic (PA) techniques have shown promise in the imaging of tissue chromophores and exogenous contrast agents various clinical applications. However, key drawback current PA technology is its dependence on a complex hazardous laser system for excitation sample. Although light-emitting diodes (LED) potential to replace laser, image quality an LED-based severely corrupted due low output power LED elements. The standard way improve increase scanning time, which leads reduction speed...
Novel severe acute respiratory syndrome coronavirus 2 (COVID-19) has become a pandemic of epic proportions, and global response to prepare health systems worldwide is utmost importance. 2-dimensional (2D) lung ultrasound (LUS) emerged as rapid, noninvasive imaging tool for diagnosing COVID-19 infected patients. Concerns surrounding LUS include the disparity patients healthcare providers, importantly, requirement substantial physical contact between patient operator, increasing risk...
Ultrasound image quality is often inherently limited by the physical dimensions of imaging transducer. We hypothesize that, collecting synthetic aperture data sets over a range positions while precisely tracking position and orientation transducer, we can synthesize large effective apertures to produce images with improved resolution target detectability. analyze two largest limiting factors for coherent signal summation: aberration mechanical uncertainty. Using an excised canine abdominal...
A sensitive, noninvasive method to detect localized prostate cancer, particularly for early detection and repetitive study in patients undergoing active surveillance, remains an unmet need. Here, we propose a molecular photoacoustic (PA) imaging approach by targeting the prostate‐specific membrane antigen (PSMA), which is over‐expressed vast majority of cancers. We performed spectroscopic PA experimental model namely, immunocompromised mice bearing PSMA+ (PC3 PIP) PSMA− flu) tumors through...
Minimally-invasive monitoring of electrophysiological neural activities in real-time—that enables quantification functions without a need for invasive craniotomy and the longer time constants fMRI PET—presents very challenging yet significant task neuroimaging. In this paper, we present vivo functional PA (fPA) imaging chemoconvulsant rat seizure model with intact scalp using fluorescence quenching-based cyanine voltage-sensitive dye (VSD) characterized by lipid vesicle mimicking different...
Abstract Optical coherence tomography (OCT) can be used to image microstructures of human kidneys. However, current OCT probes exhibit inadequate field-of-view, leading potentially biased kidney assessment. Here we present a robotic system where the probe is integrated robot manipulator, enabling wider area (covers an 106.39 mm by 37.70 mm) spatially-resolved imaging. Our comprehensively scans surface at optimal altitude with preoperative path planning and image-based feedback control...
Ultrasonography is a widely used imaging modality to visualize anatomical structures due its low cost and ease of use; however, it challenging acquire acceptable image quality in deep tissue. Synthetic aperture (SA) technique increase resolution by synthesizing information from multiple subapertures, but the improvement limited physical size array transducer. With large F-number, difficult achieve high regions without extending effective size. We propose method extend available for SA-called...
Voltage-sensitive dyes (VSDs) are designed to monitor membrane potential by detecting fluorescence changes in response neuronal or muscle electrical activity. However, imaging is limited depth of penetration and high scattering losses, which leads low sensitivity vivo systems for external detection. By contrast, photoacoustic (PA) imaging, an emerging modality, capable deep tissue, noninvasive combining near-infrared light excitation ultrasound Here, we show that voltage-dependent quenching...
We hypothesize that noninvasive photoacoustic imaging can accurately measure cerebral venous oxyhemoglobin saturation (So 2 ) in a neonatal model of hypoxia-ischemia. In piglets, which have skull thickness comparable to human neonates, we compared the measurement sagittal sinus So against measured directly by blood sampling over wide range conditions. Systemic hypoxia was produced decreasing inspired oxygen stepwise (i.e., 100, 21, 19, 17, 15, 14, 13, 12, 11, and 10%) with without unilateral...
Under the ceaseless global COVID-19 pandemic, lung ultrasound (LUS) is emerging way for effective diagnosis and severeness evaluation of respiratory diseases. However, close physical contact unavoidable in conventional clinical ultrasound, increasing infection risk health-care workers. Hence, a scanning approach involving minimal between an operator patient vital to maximize safety procedures. A robotic platform can satisfy this need by remotely manipulating probe with arm. This paper...
Radiofrequency (RF) ablation is a minimally invasive therapy for atrial fibrillation. Conventional RF procedures lack intraoperative monitoring of ablation-induced necrosis, complicating assessment completeness. While spectroscopic photoacoustic (sPA) imaging shows promise in distinguishing ablated tissue, multi-spectral challenging vivo due to low quality caused by motion. Here, we introduce cardiac-gated sPA (CG-sPA) framework enhance image using motion-gated averaging filter, relying on...
Medical ultrasound is extensively used to define tissue textures and characterize lesions, it the modality of choice for detection follow-up assessment thyroid diseases. Classical medical procedures are performed manually by an occupational operator with a hand-held probe. These require high physical cognitive burden yield clinical results that highly operator-dependent, therefore frequently diminishing trust in imaging data accuracy repetitive assessment. A robotic procedure, on other hand,...
The state-of-the-art configurations for acoustic-resolution photoacoustic (PA) microscope (AR-PAM) are large in size and expensive, hindering their democratization. While previous research on AR-PAMs introduced a low-cost light source to reduce the cost, few studies have investigated possibility of optimizing sensor actuation, particularly AR-PAM. Additionally, there is an unmet need evaluate image quality deterioration associated with actuation inaccuracy. A device system cost AR-PAM while...
Conventional manual ultrasound (US) imaging is a physically demanding procedure for sonographers. A robotic US system (RUSS) has the potential to overcome this limitation by automating and standardizing procedure. It also extends accessibility in resource-limited environments with shortage of human operators enabling remote diagnosis. During imaging, keeping probe normal skin surface largely benefits image quality. However, an autonomous, real-time, low-cost method align towards direction...
With the advancement in computing and robotics, it is necessary to develop fluent intuitive methods for interacting with digital systems, augmented/virtual reality (AR/VR) interfaces, physical robotic systems. Hand motion recognition widely used enable these interactions. configuration classification metacarpophalangeal (MCP) joint angle detection important a comprehensive reconstruction of hand motion. Surface electromyography (sEMG) other technologies have been motions. Forearm ultrasound...
Accurate estimation of human hand configuration and the forces they exert is critical for effective teleoperation skill transfer in robotic manipulation. A deeper understanding interactions with objects can further enhance performance. To address this need, researchers have explored methods to capture translate manipulation skills applied systems. Among these, biosignal-based approaches, particularly those using forearm ultrasound data, shown significant potential estimating movements finger...
Three-dimensional (3D) ultrasound (US) imaging is widely used for real-time, non-ionizing, and cost-effective medical diagnostics. However, using a one-dimensional (1D) transducer often results in limited elevational resolution due to the inherent beam thickness. In this paper, we introduce an Synthetic Aperture Focusing (SAF) algorithm specifically designed rotational 3D US imaging. Unlike previous methods requiring channel data, our approach operates on in-plane beamformed radio-frequency...
Existing ultrasound (US) image-guided needle access methods applied in various surgical procedures (such as percutaneous nephrolithotomy) face the challenge of keeping tip visible during insertion process due to unguaranteed alignment between US image and needle. We propose a mechanism with reflector-integrated imaging, where plane are mechanically aligned, is inserted forward-viewing style provide more intuitive access. An acoustic reflector used redirect while goes through slit middle so...