A5055021274- Seaweed-derived Bioactive Compounds
- Echinoderm biology and ecology
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Therapeutic Uses of Natural Elements
- Corneal surgery and disorders
- Marine and coastal plant biology
- Hydrogels: synthesis, properties, applications
- Polysaccharides and Plant Cell Walls
- Algal biology and biofuel production
- Polymer Surface Interaction Studies
- Ocular Disorders and Treatments
- Osteoarthritis Treatment and Mechanisms
- Vitamin C and Antioxidants Research
- Exercise and Physiological Responses
- Pharmaceutical Economics and Policy
- Pharmacovigilance and Adverse Drug Reactions
- Macrophage Migration Inhibitory Factor
- Microbial Metabolites in Food Biotechnology
- Biochemical effects in animals
- Aquaculture disease management and microbiota
- Dermatology and Skin Diseases
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Bioactivity Studies
- Collagen: Extraction and Characterization
GlaxoSmithKline (United Kingdom)
2019-2022
GlaxoSmithKline (United States)
2020
Research Triangle Park Foundation
2020
University of Tasmania
2005-2019
Southern Cross University
2016
Marine National Facility
2002
Lions Eye Institute
1997-2000
The University of Western Australia
1997-2000
Commonwealth Scientific and Industrial Research Organisation
1998
Vision Cooperative Research Centre
1998
Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are an important cause of morbidity impact significantly on quality life. Overall, current treatments do not sustain a long-term clinical remission associated with adverse effects, which highlight the need for new treatment options. Fucoidans complex sulphated, fucose-rich polysaccharides, found in edible brown algae described having multiple bioactivities including potent anti-inflammatory effects. Therefore,...
Two concentrated and well-characterized fucoidan-rich extracts were investigated to determine their benefits in topical applications. An Undaria pinnatifida extract, containing 85% fucoidan, a Fucus vesiculosus co-extract, 60% fucoidan 30% polyphenol, assessed number of vitro assays measure the effect on enzyme inhibition, glycation, antioxidant activity Sirtuin 1 (SIRT1) protein expression. Double-blind, placebo-controlled clinical studies also conducted soothing, protection, wrinkle depth,...
Fucoidans are sulfated, complex, fucose-rich polymers found in brown seaweeds. have been shown to multiple bioactivities, including anti-inflammatory effects, and known inhibit inflammatory processes via a number of pathways such as selectin blockade enzyme inhibition, demonstrated inhibition pathologies vivo. In this current investigation, fucoidan extracts from Undaria pinnatifida, Fucus vesiculosus, Macrocystis pyrifera, Ascophyllum nodosum, Laminaria japonica were assessed for modulation...
We have developed an antibody-based method to assess plasma uptake of a proprietary Undaria-derived fucoidan galactofucan sulfate (GFS(TM)) after oral ingestion by human volunteers. Fucoidans high-molecular-weights but exert biological effects in experimental animals intake. By using novel antibody raised against sulfated polysaccharides, we carried out competitive ELISA quantitate GFS samples from healthy volunteers who ingested 3 g/day whole Undaria containing 10% fucoidan, purified 75% or...
Corneal epithelial tissue migration over the surface of a synthetic polymer can be inhibited by pores in substrate. The effects this substrate topography upon were studied vitro. Membranes different porosities and structures used to provide two series surfaces having graded increase discontinuities: cellulose nitrate/acetate membranes with tortuous network pores, track-etched polycarbonate columnar pores. outgrowth was increased pore size, for both membranes, completely halted on mean...
ObjectiveTransplantation of hematopoietic progenitor stem cells (HPC) is an important treatment modality for a variety neoplastic diseases. HPC collection transplantation with granulocyte colony-stimulating factor may be unsuccessful in patients who have received prior chemotherapy or other reasons. Methods to improve mobilization HPCs are required. Disruption the interaction between cell surface receptor CXCR4 and its ligand stromal derived factor-1 (SDF-1) mechanism release from bone...
Seaweed-derived heparin-like substances such as fucoidan have been extensively studied in vitro potential blood anticoagulants. However, there no human studies investigating the anticoagulant activity of when administered orally. This pilot clinical trial was aimed to assess safety and effects ingestion on hemostasis well study its in-vitro activity. In a single-blinded trial, total 20 volunteers were allocated both placebo group (n = 10) who ingested 3 g guar gum capsules active treatment...
Background: Although the use of complementary and alternative medicines is widespread in cancer patients, clinical evidence their benefits sparse. Furthermore, while they are often assumed to be safe with regard concurrent anticancer therapies, few studies have been carried out investigate possible interactions. Fucoidans a group sulfated carbohydrates, derived from marine brown algae, which long used as dietary supplements due reported medicinal properties, including activity. The aim this...
Preliminary investigation of a fucoidan with demonstrated reduction in the symptoms osteoarthritis (OA) hip and knee.A double-blind randomized controlled trial was carried out to determine safety efficacy 300 mg dose Fucus vesiculosus extract (85% fucoidan) over 12-week period population (n=122) mild-to-moderate OA knee as measured by validated instrument "Comprehensive Osteoarthritis Test." Safety assessing cholesterol, liver function, renal hematopoietic closely monitoring adverse...
Inflammatory bowel disease (IBD) is a complex and multifactorial disorder characterised by relapsing remitting inflammation of the intestinal tract. Oxidative stress (OS) result an imbalance between production accumulation reactive oxygen species (ROS), which has been associated with inflammatory responses implicated in exacerbation IBD. Fucoidan, sulfated polysaccharide from brown seaweed, well-known anti-inflammatory agent emerging evidence indicates that fucoidan extracts Macrocystis...
Abstract Tasmania is an island state in south-eastern Australia that has a long and rich history of seaweed use, research, development. It cool-temperate system with 750 macroalgal species currently described. Tasmanian Aboriginal peoples have lived on this land for at least 40,000 years utilising as food, shelter, water carriers medicine, well ceremonial reasons. Modern taxonomic investigations began French naturalist Jacques-Julien Houtou de La Billardière 1791, there are 184 type...
Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels have been used in the past as ocular implants. In a recent development, PHEMA sponges shown suitable properties materials for peripheral component of an artificial cornea (keratoprosthesis). However, propensity to calcify could threaten long-term stability implanted devices. attempt improve understanding calcification mechanism, dynamics, extent, and nature calcified deposits within were investigated this study, possible correlation between...
Isolated fucoidans from brown marine algae have been shown to a range of immune-modulating effects. This exploratory study aimed determine whether seaweed nutrient complex containing blend extracts three different species plus nutrients is safe administer and has biological potential as an immune modulator. The was undertaken open-label combined Phase I II study.Participants (n = 10) were randomized receive the medication at either 100 mg 5) or 1000 dose over 4 weeks. primary outcome...
A six-week feeding trial was conducted to determine the effects of different concentrations fucoidan (1 g/kg, 10 g/kg and 30 g/kg; w/w) from Undaria pinnatifida on gibel carp (Carassius auratus gibelio). Our results demonstrated that significantly increased (p < .05) growth performance, intestinal digestive enzyme activities, acid phosphatase activity immunoglobulin M content. Histological examinations revealed receiving had significant higher abundance mucin-containing goblet cells in...
Fucoidans are known to be effective inhibitors of inflammation, and virus binding cellular entry.
Seaweed polysaccharides in the diet may influence both inflammation and gut microbiome. Here we describe two clinical studies with an Ulva sp. 84-derived sulfated polysaccharide—“xylorhamnoglucuronan” (SXRG84)—on metabolic markers, inflammation, flora composition. The first study was a double-blind, randomized placebo-controlled trial placebo, either 2 g/day or 4 of SXRG84 daily for six weeks 64 overweight obese participants (median age 55 years, median body mass index (BMI) 29 kg/m2)....