A5037499701- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Lung Cancer Diagnosis and Treatment
- Air Quality and Health Impacts
- Smoking Behavior and Cessation
- Respiratory viral infections research
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Congenital Diaphragmatic Hernia Studies
- Cystic Fibrosis Research Advances
- Mast cells and histamine
- Phosphodiesterase function and regulation
- Cancer Cells and Metastasis
- Energy and Environment Impacts
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
Universidade Federal de Minas Gerais
2025
University of Tasmania
2015-2024
Royal Prince Alfred Hospital
2022-2024
National Health and Medical Research Council
2016-2024
Tulane University
2021
Ichinomiya Kenshin College
2021
Launceston General Hospital
2018
Weatherford College
2007
The second wave of COVID-19 in India has had severe consequences the form spiralling cases, reduced supplies essential treatments, and increased deaths particularly young population. Understanding why been more dangerous than first could help to identify potential areas diagnostics target with future control strategies. Studies have identified various circulating double-mutant triple-mutant strains SARS-CoV-2 across different regions India, which are pathogenic initial strains. Such altered...
Abstract We explore potential dysregulation of macrophage phenotypes in COPD pathogenesis through integrated study human small airway tissue, bronchoalveolar lavage (BAL) and an experimental murine model COPD. evaluated tissue BAL from healthy controls, normal lung function smokers (NLFS), subjects. Both airways cells were immunohistochemically stained with anti-CD68 for total macrophages anti-CD163 M2, anti-iNOS M1 macrophages. Multiplex ELISA measured cytokines. Comparable cigarette...
Heat-not-burn (HNB) devices can alter vital physiological functions in the lung. HNB may not be a safer option than cigarette smoking or eCig vaping; this does support recommendation of their use over other nicotine delivery products. http://ow.ly/wZ5P30ng8bU.
Fucoidans are sulfated, complex, fucose-rich polymers found in brown seaweeds. have been shown to multiple bioactivities, including anti-inflammatory effects, and known inhibit inflammatory processes via a number of pathways such as selectin blockade enzyme inhibition, demonstrated inhibition pathologies vivo. In this current investigation, fucoidan extracts from Undaria pinnatifida, Fucus vesiculosus, Macrocystis pyrifera, Ascophyllum nodosum, Laminaria japonica were assessed for modulation...
COVID-19 is complicated by acute lung injury, and death in some individuals. It caused SARS-CoV-2 that requires the ACE2 receptor serine proteases to enter AEC. We determined what factors are associated with expression particularly patients asthma COPD.
Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells early disease stages remain ill defined. Chronic obstructive pulmonary (COPD) a major respiratory characterized by small-airway inflammation, emphysema, breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased early-stage COPD, molecular functional neutrophil states correlate with...
Tobacco smoking has emerged as a risk factor for increasing the susceptibility to infection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via increased expression of angiotensin-converting enzyme-2 (ACE2) in lung, linked disease 2019 (COVID-19) development. Given modifiable nature electronic cigarettes and delivery high concentrations nicotine, we investigate whether cigarette vaping potential increase SARS-CoV-2 infection. We exposed BEAS-2B cells (bronchial epithelium...
Background COPD is the third leading cause of death worldwide. Cigarette smoke (CS)-induced chronic inflammation inducing airway remodelling, emphysema and impaired lung function primary cause. Effective therapies are urgently needed. Human chymase (hCMA)1 its orthologue mCMA1/mouse mast cell protease (mMCP)5 exocytosed from activated cells have adverse roles in numerous disorders, but their role unknown. Methods We evaluated hCMA1 levels tissues patients. used mmcp5 -deficient ( −/− ) mice...
ABSTRACT Background and objective The of this study was to enumerate total cells the number inflammatory cell differentials in large airways ( LAs ) versus small SAs mild‐moderate COPD , against appropriate controls. Methods For LA we used endobronchial biopsies for SA resected lung tissues. Immunostaining enumerated (cells per mm 2 macrophages, neutrophils, CD4 CD8 T lamina propria LP up 150 µM deep full wall thickness . Results We confirmed hypocellularity smokers P < 0.001)....
Previous reports have shown epithelial-mesenchymal transition (EMT) as an active process that contributes to small airway fibrotic pathology. Myofibroblasts are highly pro-fibrotic cells secrete excessive and altered extracellular matrix (ECM). Here we relate myofibroblast presence with remodelling, physiology EMT activity in smokers COPD patients.Lung resections from nonsmoker controls, normal lung function current ex-smokers were stained anti-human α-smooth muscle actin (SMA), collagen 1...
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic interstitial lung disease. We performed size-based quantitation of arterial remodelling in IPF and examined the role endothelial-to-mesenchymal transition (EndMT) effects on physiology.Resected tissues from 11 normal controls (NCs), 13 patients were differentially stained using Movat Pentachrome technique. Size-based classification for arteries was conducted NC tissues. For each artery, size, luminal diameter,...