A5060044644- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Prostate Cancer Treatment and Research
- Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Soft tissue tumor case studies
- Bone Tumor Diagnosis and Treatments
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- Berberine and alkaloids research
- Ubiquitin and proteasome pathways
- Colorectal Cancer Screening and Detection
- Tumors and Oncological Cases
- Ear and Head Tumors
- Neurofibromatosis and Schwannoma Cases
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Kruppel-like factors research
- Infectious Disease Case Reports and Treatments
- Oral and Maxillofacial Pathology
- Wnt/β-catenin signaling in development and cancer
- Digestive system and related health
- PARP inhibition in cancer therapy
Union Hospital
2023-2025
Jilin University
2025
Shandong University of Traditional Chinese Medicine
2025
The First People’s Hospital of Lianyungang
2024
Nanjing Medical University
2024
Fudan University Shanghai Cancer Center
2006-2024
Wuxi Fourth People's Hospital
2024
Jiangnan University
2024
Shanghai Medical College of Fudan University
2011-2023
Changchun University of Science and Technology
2021-2023
Inflammatory bowel disease (IBD) is a chronic inflammatory of intestinal mucosa and submucosa, characterized by the disruption epithelial barrier, increased production mediators, excessive tissue injury. Intestinal cells, as well microvascular endothelial play important roles in IBD. To study potential effects kaempferol IBD progress, we established novel epithelial-endothelial cells coculture model to investigate inflammation barrier function. Data demonstrated an obvious transepithelial...
The purpose of this study was to compare the long-term survival patients with locally advanced cervical cancer (stages IB2-IIB) treated neoadjuvant chemotherapy followed by radical hysterectomy (hysterectomy plus pelvic lymph node dissection) (NACT + RS) those surgery (RS) or concurrent chemoradiotherapy (CCRT).A retrospective performed. Patients were up for 54 114 months (median, 82.8 months). All risk factors that may have affected disease-free (DFS) and overall (OS) assessed.From January...
The standard treatment for advanced, androgen-responsive prostate cancer is androgen deprivation therapy with or without a nonsteroidal antiandrogen, such as bicalutamide. Although maximal blockade exhibits favorable responses in the majority of patients, eventually progresses to an androgen-refractory stage. mechanism underlying bicalutamide resistance course progression incompletely understood. However, interleukin-6 (IL-6) plays critical role development and CRPC. Herein, we explored...
A photoresponsive therapeutic antibacterial platform was designed and constructed using polydopamine-functionalized selenium nanoparticles as a carrier loaded with indocyanine green (Se@PDA-ICG). The confirmed by characterization the activity of Se@PDA-ICG against Staphylococcus aureus (S. aureus) Escherichia coli (E. coli) investigated. Under 808 nm laser irradiation, rate E. S. 100% at 125 μg mL-1. Furthermore, in mouse wound infection model, closure photoresponse group 88.74% compared...
Abstract Background Circular RNAs (circRNAs) are endogenous non-coding RNAs, which associated with various biological processes, including microRNA (miRNA) interaction, protein binding and regulatory splicing. circRNA_0005529 (circ_0005529) is derived from vacuolar sorting 33 homologue B (VPS33B), its role in gastric cancer (GC) has not been examined. In this study, the expression location of circ_0005529 microRNA-527 (miR-527) were determined by qRT-PCR fluorescence situ hybridization...
Clinical data showed that the levels of interleukin-4 (IL-4) are significantly elevated in serum patients with ablation resistant prostate cancer. Previous studies demonstrated IL-4 enhances androgen receptor (AR) activation mediated by NF-kappaB absence or very low cancer cells. In this study, role promoting growth androgen-independent cells was examined.LNCaP were transfected a full-length cDNA and stable clones expressing selected. The LNCaP analyzed vitro vivo both presence...
Androgen receptor (AR) signaling not only plays a pivotal role in the development of androgen-dependent prostate cancer but is also important growth and survival castration-resistant (CRPC). The first line treatment use androgen deprivation therapy. However, most patients will eventually relapse due to CRPC. Thus, strategy target AR for CRPC urgently needed. authors have previously identified andrographolide as an inhibitor interleukin-6, which can suppress tumor cells by screening compounds...
BACKGROUND: Fibroblast growth factor receptor 4 (FGFR4) belongs to the tyrosine kinase family. Little is known about effect of FGFR4 on gastric cancer (GC). Therefore, objective current study was elucidate role in tumorigenesis and progression GC. METHODS: some common prognosis markers, including p53, neu, proliferating cell nuclear antigen (PCNA), were detected 71 tissue samples from patients with GC using immunohistochemical analysis. In addition, a series functional assays carried out...
Anomalous systemic artery to the left lower lobe (ASALLL) is a rare congenital anomaly. The primary symptoms include hemoptysis and lung infection, though some patients may remain asymptomatic. Currently, there no consensus on indications for treatment or optimal choice of therapy this condition. This case presents an asymptomatic adult who underwent coil embolization. A 48-year-old male was admitted our hospital due discovery space-occupying lesion in hilum. contrast-enhanced pulmonary...
Essential thrombocythemia (ET) is characterized by thrombotic and hemorrhagic events. The association of clinical characteristics Chinese ET patients additional sex combs like 1 (ASXL1) mutations in these has remained to be elucidated. In the present study, 72 newly diagnosed were enrolled determine ASXL1 mutations. Mutations ASXL1, Janus kinase (JAK)2, calreticulin (CALR) myeloproliferative leukemia (MPL) genes detected using Sanger sequencing, data statistically analyzed. frequencies JAK2...
Objectives: Histone deacetylase inhibitors represent a promising class of potential anticancer agents for the treatment human malignancies. In this study, effects trichostatin A (TSA) on apoptosis, metastasis-associated gene expression, and activation Notch pathway in pancreatic cancer cell lines were investigated. Methods: After with TSA, viability apoptosis evaluated using MTT [3-(4,5-dimethylthia-zol-2-yl)-2,5-diphenyltetrazolium bromide] assay, Hoechst 33258 staining, flow cytometry....
To investigate the clinicopathological features, immunophenotype, diagnosis and differential of SRF-rearranged cellular perivascular myoid tumor.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated possible link between RNA editing and PCOS, yet the actual role editing, its association with clinical features, underlying mechanisms remain unclear.
Emphysematous pyelonephritis is a rare and severe urinary tract infection that potentially life-threatening easily progresses to septic shock. In this report, we present unique case of emphysematous caused by Raoultella ornithinolytica. An 86-year-old man presented with back pain 3 days' duration. He had history hypertension diabetes for more than 20 years, his indicators serum creatinine were elevated. Abdominal computed tomography revealed an abnormal gas shadow around right kidney the...
You have accessJournal of Urology1 Apr 2008INTERLEUKIN-4 ACTIVATES ANDROGEN RECEPTOR THROUGH CBP/p300 MEDIATED ACETYLATION AND STIMULATES INDEPENDENT GROWTH Soo Lee, Jae Chun, Meng Sun, and Allen Gao LeeSoo Lee More articles by this author , ChunJae Chun SunMeng Sun GaoAllen View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60296-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "INTERLEUKIN-4 GROWTH." The...