A5101881540- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Drug Solubulity and Delivery Systems
- Selenium in Biological Systems
- Polymer Surface Interaction Studies
- Advancements in Transdermal Drug Delivery
- Immune Cell Function and Interaction
- Carbon and Quantum Dots Applications
- Nanoparticle-Based Drug Delivery
- Biopolymer Synthesis and Applications
- 2D Materials and Applications
- Lung Cancer Treatments and Mutations
- Metal-Organic Frameworks: Synthesis and Applications
- Protein purification and stability
- Surfactants and Colloidal Systems
- Oral Health Pathology and Treatment
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- T-cell and B-cell Immunology
- Oral health in cancer treatment
- Analytical Methods in Pharmaceuticals
- Cholinesterase and Neurodegenerative Diseases
- Chemokine receptors and signaling
- Traditional Chinese Medicine Studies
Changchun University of Science and Technology
2021-2023
Dalian Medical University
2009-2018
First Affiliated Hospital of Dalian Medical University
2009-2018
Shenyang Pharmaceutical University
2005-2012
Roswell Park Comprehensive Cancer Center
2011
Virginia Commonwealth University
2011
Beijing Normal University
2011
Institute of Molecular Medicine
2011
Osaka University
2000-2002
Sumitomo Hospital
2000
Background/Aims: Intestinal mucositis (IM) is a commonly encountered side effect in cancer patients receiving chemotherapy. This study aimed to investigate the of Bifidobacterium infantis (B. infantis) attenuating severity chemotherapy-induced intestinal by regulating T cell subsets rats with colorectal (CRC). Methods: Thirty male Sprague-Dawley (SD) were injected dimethyl hydrazine (DMH) subcutaneously for 10 weeks, and then SW480 cells rectal mucosa create CRC model, randomly divided into...
Although dendritic cell (DC) vaccines offer promise as cancer immunotherapy, further improvements are needed to amplify their clinical therapeutic efficacy. The pattern recognition scavenger receptor SRA/CD204 attenuates the ability of DCs activate CD8(+) T-cell responses. Therefore, we examined impact on antitumor responses generated by DC and also evaluated feasibility enhancing vaccine potency blockade. from SRA/CD204-deficient mice were more immunogenic in generating B16 melanoma,...
The effective chemotherapy treatment for liver cancer patients remains an urgent issue due to the difficulty in precisely delivering drugs tumor site. targeted delivery of by nanoparticles is a promising strategy address this problem. However, fabrication drug nanosystem still major challenge. In study, novel folic acid-functionalized (doxorubicin, DOX) DOX@ZIF-8 (DOX@ZIF-8-FA) were prepared as cancer-targeted system. exhibited high loading capacity (15.7 wt%) and presented excellent...
A photoresponsive therapeutic antibacterial platform was designed and constructed using polydopamine-functionalized selenium nanoparticles as a carrier loaded with indocyanine green (Se@PDA-ICG). The confirmed by characterization the activity of Se@PDA-ICG against Staphylococcus aureus (S. aureus) Escherichia coli (E. coli) investigated. Under 808 nm laser irradiation, rate E. S. 100% at 125 μg mL-1. Furthermore, in mouse wound infection model, closure photoresponse group 88.74% compared...
The purpose of this study was to investigate the possibility parenteral delivery poorly water-soluble lipophilic drugs using a phospholipid-based microemulsion system. Ibuprofen eugenol ester (IEE), highly compound, synthesized from ibuprofen and eugenol, isolated as an amorphous whitish solid with melting point at 40.2+/-0.1 degrees C, which structure confirmed by IR, 1H-NMR MS spectra. A pharmaceutically acceptable system Miglyol 812, soybean phosphatidylcholine (SbPC) poly (ethylene...
Backgrounds: Rebamipide (REB) is classified as a Biopharmaceutics Classification System (BCS) Class-IV compound with poor aqueous solubility and permeability. The local concentration in the mucosa makes REB exhibiting therapeutic activities, strategy of increasing dissolution rate has possibility to improve oral gastrointestinal (GI) distribution when using nanosuspensions.Objective: purpose this work was prepare nanosuspensions (REB-NSs) by combining neutralization microfluidization its...
Abstract Interleukin (IL)-12 plays a central role in the initiation and regulation of T cell-mediated immune responses. The present study investigated how IL-12, endogenously produced during tumor vaccination, functions for anti-tumor Mice were given anti-IL-12 monoclonal antibody immunization with attenuated syngeneic cells. Splenic cells from anti-IL-12-treated immunized mice exhibited comparable levels tumor-neutralizing activity those tumor-immunized without treatment. When these two...
Interleukin-12 (IL-12) treatment is effective in the CSA1M but not Meth A and CSA1M-variant tumor models. The authors investigated cause by which IL-12 fails to induce regression these two T cells from CSA1M-bearing mice have high levels of responsiveness, whereas A–bearing display marginal responsiveness. Because responsiveness induced after T-cell receptor stimulation, lack suggests that are sensitized antigen. Immunization normal with attenuated resulted a protective immunity, as shown...
Abstract Review: 89 refs.
Abstract Background Bacterial infections have always been one of the medical challenges facing mankind. Compared with conventional antibiotic therapy, photoresponsive synergistic antibacterial offers a new therapeutic modality. Results Herein, platform was designed and constructed by polydopamine-functionalized selenium nanoparticles as carrier loading indocyanine green (Se@PDA-ICG). The confirmed characterization activity Se@PDA-ICG against Staphylococcus aureus (S. aureus) Escherichia coli...