A5101398746- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Diabetes Treatment and Management
- Electrolyte and hormonal disorders
- Lipoproteins and Cardiovascular Health
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Analytical Chemistry and Chromatography
- Advancements in Transdermal Drug Delivery
- Evaluation and Optimization Models
- Crystallization and Solubility Studies
- Helicobacter pylori-related gastroenterology studies
- Pharmaceutical Practices and Patient Outcomes
- Chromatography in Natural Products
- Cancer Treatment and Pharmacology
- Nanoparticle-Based Drug Delivery
Shenyang Pharmaceutical University
2016-2025
Anhui University of Science and Technology
2013-2025
Central South University
2012-2022
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
Anhui Medical University
2008-2018
First Affiliated Hospital of Anhui Medical University
2008-2018
China National Environmental Monitoring Center
2014
Philadelphia VA Medical Center
2013
Shenyang First People's Hospital
2011
Tigecycline is one of the few therapeutic options for treating infections caused by some multi-drug resistant pathogens, such as Klebsiella pneumoniae. However, tigecycline-resistant K. pneumoniae has been discovered recently in China. From 2009 to 2013, nine isolates were identified our hospital. Six strains before using tigecycline. To investigate efflux-mediated resistance mechanisms pneumoniae, expression efflux pump genes (acrA, acrB, tolC, oqxA and oqxB) regulators (acrR, marA, soxS,...
AIM:To investigate Time-and pH-dependent colon-specific drug delivery systems (CDDS) for orally administered diclofenac sodium (DS) and 5-aminosalicylic acid (5-ASA), respectively.METHODS: DS tablets 5-ASA pellets were coated by ethylcellulose (EC) methacrylic copolymers (Eudragit ® L100 S100), respectively.The in vitro release behavior of the examined, then vivo absorption kinetics dogs further studied. RESULTS:Release profile time-dependent was not influenced pH dissolution medium, but lag...
Objective: Several disproportionality analysis methods are widely used for signal detection. The goal of this study was to compare the concordance performance characteristics these in spontaneous reporting system China. Methods: Algorithms including odds ratio (ROR), proportional (PRR) and information component (IC), a composite criterion previously by Medicines Healthcare Products Regulatory Agency (MHRA) were compared. Kappa coefficient as gauge test concordance. Reports received year 2004...
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim this study was physicochemical properties aprepitant by preparation solid dispersions. were characterized dissolution, FTIR, XRPD, DSC, SEM pharmacokinetic studies in rats. significantly increased dispersions, XRD, analysis indicated that existed an amorphous form within result showed SDs nearly five-fold faster than aprepitant....
Successful chemotherapy with paclitaxel (PTX) is impeded by multidrug resistance (MDR) in tumor cells. In this study, lipid-albumin nanoassemblies co-loaded borneol and (BOR/PTX LANs) were prepared to circumvent MDR C6 glioma The physiochemical properties including particle size, encapsulation efficiency morphology evaluated vitro. Quantitative qualitative investigations of cellular uptake carried out cytotoxicity the BOR/PTX LANs was determined MTT assay. After that, targeting also bearing...
The purpose of the present study was to optimize formulations thermoresponsive ophthalmic in situ gels a poorly water-soluble drug fluconazole (FLU) and evaluate vitro vivo properties formulations. FLU were prepared by mixing FLU, Poloxamer407, Tween80, benzalkonium chloride carbopol934 borate buffer solution. eye irritation tests absorption carried out rabbits. formulation compositions influenced physicochemical gels. amount poloxamer407 main factor that affected sol–gel transition...
A temperature-sensitive hydrogel encapsulating tegafur and protoporphyrin IX dimers could be delivered intratumorally for synergetic chemotherapy photodynamic therapy.