A5053058181- Hair Growth and Disorders
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- melanin and skin pigmentation
- Skin and Cellular Biology Research
- Alzheimer's disease research and treatments
- Biochemical and Structural Characterization
- Cellular transport and secretion
- Trypanosoma species research and implications
- Chemical Synthesis and Analysis
- Dermatological and Skeletal Disorders
- Research on Leishmaniasis Studies
- Enzyme Production and Characterization
- Cancer-related gene regulation
- S100 Proteins and Annexins
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
- CAR-T cell therapy research
- Iron Metabolism and Disorders
- Stress Responses and Cortisol
- Gestational Diabetes Research and Management
- Pluripotent Stem Cells Research
- Endoplasmic Reticulum Stress and Disease
University of Cape Town
2017-2024
South African Medical Research Council
2024
Groote Schuur Hospital
2017-2023
Rhodes University
2013
Abstract Maternal obesity and gestational diabetes mellitus (GDM) are associated with insulin resistance health risks for mother offspring. Obesity is also characterized by low‐grade inflammation, which in turn, impacts sensitivity. The placenta secretes inflammatory cytokines hormones that influence maternal glucose handling. However, little known about the effect of obesity, GDM their interaction, on placental morphology, cytokines. In a South African cohort non‐obese obese pregnant women...
Proteases are critical enzymes in cellular processes which regulate intricate events like proliferation, differentiation and apoptosis. This review highlights the multifaceted roles of serine proteases FAM111A FAM111B, exploring their impact on functions diseases. is implicated DNA replication fork protection, thereby maintaining genome integrity. Additionally, as an antiviral factor against RNA viruses. Apart from being involved repair, a paralog FAM111A, participates cell cycle regulation...
Abstract Angiotensin-converting enzyme (ACE) is a zinc metalloprotease best known for its role in blood pressure regulation. ACE consists of two homologous catalytic domains, the N- and C-domain, that display distinct but overlapping functions vivo owing to subtle differences substrate specificity. While current generation inhibitors target both domain-selective may be clinically advantageous, either reducing side effects or having utility new indications. Here, we used site-directed...
The aim of this study was to explore the inhibitory potential apoferritin or apoferritin-capped metal nanoparticles (silver, gold and platinum) against Trypanosomabrucei arginine kinase. kinase activity determined in presence absence nanoparticles. In addition, kinetic parameters relative inhibition enzyme were estimated. Apoferritin nanoparticles’ interaction with T. brucei led a >70% reduction activity. Further analysis determine suggests mixed by apoferritin-nanoparticles, decrease...
Mutations in the uncharacterised human FAM111B gene are associated with POIKTMP, a rare multi-organ fibrosing disease. Recent studies also reported overexpression of specific cancers. Moreover, mutation screening may prove expensive under-resourced facilities. Therefore, this study investigated its cellular function and dysfunction described an inexpensive method. expression was assessed silico validated vitro cell lines primary skin fibroblasts from South African POIKTMP-patient...
Abstract Background Mutations of the human FAM111B gene are associated with hereditary fibrosing poikiloderma tendon contracture, myopathy, and pulmonary fibrosis (POIKTMP), a rare autosomal dominant multi-systemic disease. To date, total 36 cases documented, eleven mutations identified confirmed by Whole-Exome Sequencing Sanger sequencing. However, these methods require certain level expertise. The was annotated using SNAPGENE tool to identify various restriction enzymes. enzymes that cut...
Most hair relaxers or straighteners used for Afro-textured have a pH above 11. This pH, according to international occupational health and safety guidelines, is corrosive the skin. Further, are associated with 3-6 times increased risk of alopecia. The skin also gets into contact these straightening products during application resulting in irritation. Using animals as test subjects determine products' potential margin standard practice; however, European Union (EU) ban on animal testing,...
ABSTRACT Glioblastoma multiforme (GBM) is an aggressive grade IV primary malignant tumour which accounts for 78 % of all brain tumours. K0513 a GBM biomarker that upregulated in the invasive phenotype. expressed ubiquitously and reportedly enriched cerebral cortex brain. further implicated signalling pathways involving neuroplasticity, cytoskeletal regulation apoptosis. The protein encoded by prospective pancreatic cancer prognosis. However, gene product K0153 not well characterised. This...