A5082934880- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
- Surface and Thin Film Phenomena
- Genital Health and Disease
- Pregnancy-related medical research
- Ovarian cancer diagnosis and treatment
- Cancer survivorship and care
- Intraperitoneal and Appendiceal Malignancies
- Salmonella and Campylobacter epidemiology
- COVID-19 Impact on Reproduction
- Hepatitis B Virus Studies
- Molecular Junctions and Nanostructures
- Quantum and electron transport phenomena
- Pelvic floor disorders treatments
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- Advanced Chemical Physics Studies
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Gestational Trophoblastic Disease Studies
- Occupational Health and Performance
- Colorectal Cancer Screening and Detection
- Immunotherapy and Immune Responses
- Childhood Cancer Survivors' Quality of Life
University of Southern Denmark
2020-2025
Odense University Hospital
1994-2025
IMEC
2024
Regional Hospital Randers
1996-2024
Holbæk Sygehus
2024
Copenhagen University Hospital
2023-2024
Aarhus University Hospital
2011-2023
Aarhus University
1996-2023
University of Copenhagen
2001-2023
Rigshospitalet
2023
The investigational 9-valent viruslike particle vaccine against human papillomavirus (HPV) includes the HPV types in quadrivalent (qHPV) (6, 11, 16, and 18) five additional oncogenic (31, 33, 45, 52, 58). Here we present results of a study efficacy immunogenicity 9vHPV women 16 to 26 years age.
Large-amplitude electron density oscillations were observed on a Be(0001) surface by means of variable-temperature scanning tunneling microscopy. Fourier transforms the images showed ring radius 2kF, where kF is Fermi wave vector state. This wavelength was expected from Friedel caused electronic screening defects, but amplitude waves for energies near energy anomalously large and inconsistent with concept screening. The enhanced must be many-body effect, either in gas (possibly an incipient...
A 9-valent human papillomavirus (9vHPV) vaccine has been developed to prevent infections and diseases related HPV 6/11/16/18 [as per the licensed quadrivalent (qHPV) vaccine], as well 5 additional oncogenic types (HPV 31/33/45/52/58). Compared with qHPV vaccine, 9vHPV potentially increases coverage of protection from 70% 90% cervical cancers. We compared immunogenicity safety versus in 9-15-year-old girls.Participants (n = 600) were randomized receive or vaccines on day 1, month 2 6....
Abstract Introduction We identified risk factors and outcomes associated with SARS‐CoV‐2 infection in pregnancy a universally tested population according to disease severity validated information on during national health registers Denmark. Material methods Cohort study using data from medical records including all pregnancies between March 1, 2020 February 28, 2021. compared women positive test non‐infected pregnant women. Risk were assessed by Poisson Cox regression models stratified...
Abstract Background This study aimed to establish a feasible large porcine model for dynamic assessment of cisplatin concentrations in carcinomatosis-relevant abdominal tissues using microdialysis during and after HIPEC combined with cytoreductive surgery. Methods In total, eight pigs underwent open surgery followed by HIPEC. Microdialysis was employed concentration sampling organs tissue. Cisplatin dialysate were analyzed the UPLC-MS/MS method. STATA (version 18.0) used perform...
Direct images of the two-dimensional Fermi contour at a surface can be generated by Fourier transform (FT) scanning tunneling microscopy (STM) taken low-bias voltages. The origins in FT are standing waves electrons near energy caused defects surface. Several examples FT-STM presented to illustrate simplicity this technique. advantages and limitations imaging technique discussed.
To determine the effects of one or two conisations on preterm delivery and perinatal mortality in subsequent pregnancies.A population-based cohort study.Aarhus University Hospital.Preterm rates were evaluated 721 deliveries after conisation, 37 conisations, compared with 390 dysplasia 74 552 that not preceded by conisation dysplasia.Cox regression was used to evaluate mortality.Birthweight, gestational age (prior 28, 32, weeks gestation, respectively) mortality.The risk increased [adjusted...
Abstract Background State Trait Anxiety Inventory (STAI) scale was developed in the 1980’s and has been widely used both clinical settings research. However Danish version of STAI not validated. The aim this study to assess validity reliability - state anxiety women aged 45 years older with abnormal cervical cancer screening results. Methods Women ≥45 referred an cytology healthy volunteers ( n = 12) underwent cognitive interview after completing STAI. Further, sent out electronic...
Cervical intraepithelial neoplasia grade 2 has historically been the threshold for surgical excision, but because of high regression rates, many countries are transitioning to active surveillance. However, estimates rates based on small studies with heterogeneous definitions and progression.This study aimed describe progression cervical using nationwide healthcare registry data.This was a population-based cohort women aged 18 40 years who had undergone surveillance in Denmark from 1998 2020....
To describe the long term risk of cervical cancer in women with untreated (that is, undergoing active surveillance) or immediately treated intraepithelial neoplasia grade 2 (CIN2).Nationwide population based historical cohort study.Danish healthcare registries.Women CIN2 diagnosed 1998-2020 and aged 18-40 years at diagnosis, who had either surveillance immediate treatment large loop excision transformation zone (LLETZ). Women a previous record worse LLETZ were excluded.A Weibull survival...
In recent years, active surveillance has been introduced as an alternative to excisional treatment in younger women with cervical intraepithelial neoplasia grade 2 because regression rates are high and is associated increased risk of preterm birth. However, early identification at persistence/progression important ensure timely treatment. Evidence limited on biomarkers that may be used identify persistence/progression.
ABSTRACT The incidence of human infection with Campylobacter jejuni is increasing in most developed countries and the reason for this largely unknown. Although poultry meat considered to be a major source, it evident that other reservoirs exist, possibly common humans poultry. Environmental sources are believed important broiler chicken flocks. We investigated potential importance wildlife as source commercial flocks by comparing serotype distributions, fla types, macrorestriction profiles...
The interaction of largish molecules with metal surfaces has been studied by combining the imaging and manipulation capabilities scanning tunneling microscope (STM). At atomic scale, STM results directly reveal that adsorption a organic molecule can induce restructuring surface underneath. This anchors on substrate is driving force for self-assembly process into characteristic molecular double rows.
We evaluated the role of beetles infesting broiler chicken rearing facilities as potential reservoirs for Salmonella enterica infections between successive flocks. In addition, their thermophilic Campylobacter spp. was also investigated. Fourteen houses located at 11 different farms were included in study. The nonrandomly selected on basis salmonella status; nine persistently contaminated with whereas five negative.For each house, two consecutive flocks (i.e., 28 all) well collected during...
The design and performance of a fast-scanning, low- variable-temperature, scanning tunneling microscope (STM) incorporated in an ultrahigh vacuum system is described. sample temperature can be varied from 25 to 350 K by cooling the using continuous flow He cryostat counter heating W filament. changed tens degrees on time scale minutes, possible within minutes after change. By means software implemented active drift compensation rate as low 1 nm/day. STM rigid, very compact, weight, attached...
Abstract Objectives To evaluate the accuracy of different preoperative modalities for staging endometrial cancer to restrict extensive surgery patients at high risk metastatic disease. Setting Aarhus University Hospital. Population 156 women referred in 2006–2011 because atypical hyperplasia (G0) or cancer. Methods Patients were offered transvaginal ultrasonography ( TVS ), magnetic resonance imaging MRI and hysteroscopic‐directed biopsies from uterine tumor cervix. Final pathology removed...
Almost all premalignant and malignant lesions of the cervix occur in women infected with human papillomavirus (HPV). Vaccination HPV prevents infection disease caused by several oncogenic types. Current vaccines prevent approximately 70% cervical cancers through protection from HPV-16 HPV-18. The investigational 9-valent (9vHPV) viruslike particle vaccine contains 4 types present quadrivalent (qHPV) (types 6, 11, 16, 18) plus 5 additional (31, 33, 45, 52, 58). Increased coverage provided...
We report on a novel diffusion mechanism for one-dimensional platinum clusters the anisotropic $\mathrm{Pt}\left(110\right)\ensuremath{-}(1\ifmmode\times\else\texttimes\fi{}2)$ surface. The mechanism, which is revealed from atom-resolved, time-lapsed scanning tunneling microscopy movies, entails that end atom of cluster promoted up to next layer, migrates over cluster, and drops down again, resulting in displacement by one lattice spacing. activation barriers ascend descend edges are...
The pregnancy associated hormone relaxin induces loosening of the pelvic ligaments in several species. This study was undertaken to evaluate whether pregnant women with symptom-giving girdle relaxation had increased serum concentrations during pregnancy.Serum were measured 38 at time diagnosis, 30th and 38th week as well 2 6 months after delivery. Fourteen without symptoms served a control group. Relaxin by homologous enzyme linked immuno-sorbent assay. All participants clinically examined...
By studying two-dimensional (2D) Fourier transforms of scanning tunneling microscopy (FT-STM) images, we obtain information about the role surface states versus bulk in screening defects and step edges at close-packed Cu Au surfaces. The STM obtained low temperature bias voltage, exhibit wave interference patterns originating from energy-resolved Friedel oscillations surface- state electrons created by defects. FT-STM pictures directly yield images 2D Fermi contour. Here present results for...