A5075017238- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Soft tissue tumor case studies
- Endometrial and Cervical Cancer Treatments
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Bone Tumor Diagnosis and Treatments
- AI in cancer detection
- Intraperitoneal and Appendiceal Malignancies
- Gestational Trophoblastic Disease Studies
- Cancer Cells and Metastasis
- IgG4-Related and Inflammatory Diseases
- Breast Implant and Reconstruction
- Multiple and Secondary Primary Cancers
- Vasculitis and related conditions
- PI3K/AKT/mTOR signaling in cancer
- Lymphatic System and Diseases
Metaxa Hospital
2003-2024
St Savas Hospital
2007
Western Infirmary
2003
International Breast Cancer Study Group
1998
National Institutes of Health
1997
Abstract BACKGROUND The number of mitoses and, thus, the proliferative capacity a tumor is one most crucial variables for grading. Ki‐67 nuclear antigen may be considered as an alternative to mitotic counts in grading schemes and single parameter that can used fine‐needle aspirates small biopsies. METHODS Immunohistochemistry using anti‐Ki‐67 antibody MIB‐1 was performed on 434 breast carcinoma specimens from International Breast Cancer Study Group (formerly Ludwig) Trial V. Three groups...
PURPOSE To assess the prognostic importance of thymidylate synthase (TS) expression in breast tumors patients with early-stage cancer, and to determine whether benefit chemotherapy (CT) is associated TS expression. PATIENTS AND METHODS The level was evaluated 210 node-negative 278 node-positive enrolled onto Trial V International Breast Cancer Study Group ([IBCSG] formerly Ludwig Group) a median follow-up time 8.5 years. assessed using immunohistochemical method monoclonal antibody 106 on...
Histologic grade is well recognized for its prognostic significance in cases of primary operable invasive breast carcinoma; however, the majority studies which has been assessed have based on single-center trials. In addition, role predicting response to chemotherapy not examined many previous studies.The authors value Nottingham histologic (NHG) a group 465 patients enrolled multicenter, randomized International Breast Cancer Study Group clinical trial adjuvant with lymph node (LN) positive...
Background The aim of the present study was to investigate efficacy adjuvant dose-dense sequential chemotherapy with epirubicin, paclitaxel, and CMF in subgroups patients high-risk operable breast cancer, according tumor subtypes defined by immunohistochemistry (IHC). Materials Methods Formalin-fixed paraffin-embedded (FFPE) tissue samples from 1,039 participating two phase III trials were centrally assessed micro-arrays IHC for 6 biological markers, that is, estrogen receptor (ER),...
Background-Aim To evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, E1, p21, p27 and p53 in context various breast cancer subtypes. Methods Cyclin p53, p21 were evaluated with immunohistochemistry 1077 formalin-fixed paraffin-embedded tissues from patients who had been treated within clinical trials. Jaccard distances computed for markers resulted matrix was used conducting unsupervised hierarchical clustering, order to identify distinct groups correlating...
Primary osteogenic sarcomas of the breast are extremely rare neoplasms. The histologic and cytologic features comparable to those their soft tissue skeletal counterparts. To assess utility fine needle aspiration (FNA) in preoperative identification sarcomas, we retrospectively reviewed FNA findings 3 cases diagnosed our hospital over 2 1/2 years.Three women, aged 48, 55 76 years, presented with a palpable lump few months' duration breasts. was indicative malignancy, mastectomy ipsilateral...
Histone H2AX undergoes phosphorylation as an answer to DNA double-strand breaks, which in turn are part of the oncogenic procedure. The detection gamma-H2AX can potentially serve a biomarker for transformation normal tissue premalignant and consequently malignant tissues. aim this study was evaluate clinical significance expression breast cancer. Gamma-H2AX tissues from 110 cancer patients analyzed by immunohistochemistry correlated with clinicopathological variables. Greater tumor size,...
A recent theory supports that high-grade serous epithelial ovarian cancer derives from the fimbrial end of fallopian tube and during last decade, a few studies have examined cytology. Our study aims to determine cytomorphological characteristics both benign non-benign salpingeal samples, in order establish cytology as valuable diagnostic test for women with high risk development ovarian/fallopian/peritoneal cancer.Our included patients undergoing salpingoophorectomy or total hysterectomy any...
Sarcomas of the breast constitute less than 1% all malignant tumors and primary rhabdomyosarcoma (RMS) is a very rare entity with limited case reports in literature. RMS common children adolescents adults. Primary arising from exceedingly We report 60-year-old woman, who presented an early stage, mimicking invasive ductal carcinoma clinically complete remission after three years diagnosis one year treatment.
Renal cell carcinoma (RCC) is proved to be the ninth most common malignancy. Two-third of patients suffering from RCC will present metastases. Secondary metastases spermatic cord are very rare.In this report we case a patient with renal metachronous metastasis occurring two years after initial diagnosis disease.Our was treated according EAU guidelines. The metastatic tumor diagnosed accidentally, in contrast previous follow-up exams which show no disease meantime. Moreover, histological...
Primary malignant germ cell tumors of the mediastinum are extremely rare among females. choriocarcinoma is a form extragonadal tumor that has poorer prognosis in comparison to other extragenital
Background: Silicone lymphadenopathy is a recognized complication of silicone implant rupture. It occurs when droplets migrate from breast implants to lymph nodes, resulting in the formation granulomas (known as siliconoma) and node enlargement. The ipsilateral axillary nodes are most commonly involved but it can also affect contralateral axillary, supraclavicular, internal mammary mediastinal nodes.Case presentation: A 60-year-old woman with history left cancer who had undergone modified...
Small cell carcinomas (SCCs) are poorly differentiated neuroendocrine tumors that arise predominantly in the lung and gastrointestinal tract (GIT). Neuroendocrine can occur a variety of extrapulmonary sites throughout body, including breast, larynx, GIT, prostate, urinary bladder, ovary cervix. This is case report 55-year-old Asian female patient with metastatic high-grade carcinoma unknown origin responded notably to off-label nivolumab maintenance treatment after first-line carboplatin -...