A5019749812- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Gut microbiota and health
- Infant Development and Preterm Care
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- Genetic Associations and Epidemiology
- Child and Adolescent Health
- IL-33, ST2, and ILC Pathways
- Tracheal and airway disorders
- Digestive system and related health
- Childhood Cancer Survivors' Quality of Life
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Pharmaceutical studies and practices
- Respiratory viral infections research
- Delphi Technique in Research
- Phonocardiography and Auscultation Techniques
- Peptidase Inhibition and Analysis
University of the Basque Country
2016-2025
Biogipuzkoa Health Research Institute
2015-2025
Donostiako Unibertsitate Ospitalea
2012-2025
Osakidetza
2010-2017
Boston Children's Hospital
2010
Hospital Materno-Infantil
2009
Rationale: Early identification of children with poorly controlled asthma is imperative for optimizing treatment strategies. The analysis exhaled volatile organic compounds (VOCs) an emerging approach to identify prognostic and diagnostic biomarkers in pediatric asthma. Objectives: To assess the accuracy gas chromatography-mass spectrometry based metabolite differentiate between uncontrolled Methods: This study encompassed a discovery (SysPharmPediA) validation phase (U-BIOPRED, PANDA)....
The raised volume rapid thoracoabdominal compression (RVRTC) technique is commonly used to obtain full forced expiratory manoeuvres from infants, but reference equations derived 'in-house' equipment have been shown be inappropriate for current commercially available devices. <h3>Aim</h3> To explore the impact of differences on RVRTC outcomes, derive robust equipment-specific ranges and investigate their potential clinical data interpretation. <h3>Method</h3> healthy subjects using Jaeger...
Substantial variability in response to asthma treatment with inhaled corticosteroids (ICS) has been described among individuals and populations, suggesting the contribution of genetic factors. Nonetheless, only a few genes have identified date. We aimed identify variants associated exacerbations despite ICS use European children young adults validate findings non-Europeans. Moreover, we explored whether gene-set enrichment analysis could suggest potential novel therapies.A genome-wide...
Background/Objectives: Metered-dose inhalers (MDIs) and dry powder (DPIs) are common inhaled corticosteroid (ICS) inhaler devices. The difference in formulation administration technique of these devices may influence oral cavity microbiota composition. We aimed to compare the saliva microbiome children with moderate-to-severe asthma using ICS via MDIs versus DPIs. Methods: Saliva samples collected from 143 (6–17 yrs) across four European countries (The Netherlands, Germany, Spain, Slovenia)...
ABSTRACT Background Asthma exacerbations (AEs) represent the major contributor to global asthma burden. Although genetic and environmental factors have been associated with AEs, role of epigenetics remains uncovered. Objective This study aimed identify whole blood DNA methylation (DNAm) markers AEs in Europeans. Methods DNAm was assessed 406 samples from Spanish individuals using Infinium MethylationEPIC microarray (Illumina). An epigenome‐wide association conducted test at differentially...
Childhood asthma has been linked to distinct metabolomic profiles. To identify phenotypes (metabotypes) in children with moderate-to-severe through integrative fecal and serum metabolome analysis. Children from the Systems Pharmacology Approach Uncontrolled Pediatric Asthma cohort Global Initiative for treatment step ≥3 were recruited. control was defined by Control Test annual exacerbation history. Targeted metabolomics profiling of feces performed using liquid chromatography flow injection...
Abstract Background Airway diseases are highly prevalent in infants and cause significant morbidity. We aimed to determine the incidence risk factors for respiratory morbidity a Spanish cohort of moderate‐to‐late preterm ( MLP ) prospectively followed during their first year life. Methods SAREPREM is multicenter, prospective, longitudinal study. Preterm born at 32–35 weeks gestation with no comorbidities were enrolled within 2 life 2–4 weeks, 6, 12 months age. Multivariate mixed‐models...
Asthma is a chronic inflammatory disease of the airways. patients may experience potentially life-threatening episodic flare-ups, known as exacerbations, which significantly contribute to asthma burden. The Pi*S and Pi*Z variants SERPINA1 gene, usually involve alpha-1 antitrypsin (AAT) deficiency, had previously been associated with asthma. link between AAT deficiency might be represented by elastase/antielastase imbalance. However, their role in exacerbations remains unknown. Our objective...
BackgroundThe upper-airway microbiome is involved in asthma exacerbations despite inhaled corticosteroid (ICS) treatment. Although human genetics regulates composition, its influence on asthma-related airway bacteria remains unknown.ObjectiveWe sought to identify genes and biological pathways regulating airway-microbiome traits ICS response.MethodsSaliva, nasal, pharyngeal samples from 257 European patients with were analyzed. The association of 6,296,951 genetic variants...
Background In the USA, genetically admixed populations have highest asthma prevalence and severe exacerbations rates. This could be explained not only by environmental factors but also genetic variants that exert ethnic-specific effects. However, no admixture mapping has been performed for exacerbations. Objective We sought to identify associated with in Hispanic/Latino subgroups means of analyses fine mapping, assess their transferability other potential functional roles. Methods an 1124...
Abstract Background Data addressing short‐ and long‐term respiratory morbidity in moderate‐late preterm infants are limited. We aim to determine the incidence of recurrent wheezing associated risk protective factors these during first 3 years life. Methods Prospective, multicenter birth cohort study born at 32 +0 35 weeks’ gestation followed for assess physician‐diagnosed wheezing. Allergen sensitization pulmonary function were also studied. used multivariate mixed‐effects models identify...
Abstract Background Uncontrolled asthma can lead to severe exacerbations and reduced quality of life. Research has shown that the microbiome may be linked with characteristics; however, its association control not been explored. We aimed investigate whether gastrointestinal used discriminate between uncontrolled controlled in children. Methods 143 103 feces samples were obtained from children moderate‐to‐severe aged 6 17 years SysPharmPediA study. Patients classified as or asthmatics, their...
There is a clinical need to identify children with poor asthma control as early possible, optimize treatment and/or find therapeutic alternatives. Here, we present the “Systems Pharmacology Approach Uncontrolled Pediatric Asthma” (SysPharmPediA) study, which aims establish pediatric cohort of moderate-to-severe uncontrolled and controlled patients asthma, investigate pathophysiological mechanisms underlying in on maintenance treatment, using multi-omics systems medicine approach. In this...
Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, influence DNAm on BDR FeNO scarcely investigated. This study aims identify markers in whole blood associated either with or We analyzed 121 samples from children moderate-to-severe The association genome-wide has been assessed using regression models,...
Objective. The aim of this post hoc analysis was to establish the relationship between FENO levels and asthma predictive index (API) among infants with recurrent wheezing. Methods. Infants wheezing (three or more episodes) were recruited consecutively online tests at tidal breathing multiple breaths performed. Results. Twenty-seven (84%) out 32 (median age 12 months) who met inclusion criteria for analysis, successfully performed determinations. Eighteen (66%) classified positive stringent...