Abstract Reported here is the first catalytic atroposelective electrophilic amination of indoles, which delivers functionalized atropochiral N ‐sulfonyl‐3‐arylaminoindoles with excellent optical purity. This reaction was furnished by 1,6‐nucleophilic addition to p ‐quinone diimines. Control experiments suggest an ionic mechanism that differs from radical pathway commonly proposed for 1,6‐addition quinones. The origin selectivity investigated through computational studies. Preliminary studies...

Abstract Small molecules with conformationally rigid, three-dimensional geometry are highly desirable in drug development, toward which a direct, simple-to-complexity synthetic logic is still of considerable challenges. Here, we report intermolecular aza-[2 + 2] photocycloaddition (the aza-Paternò–Büchi reaction) indole that facilely assembles planar building blocks into ladder-shape azetidine-fused indoline pentacycles contiguous quaternary carbons, divergent head-to-head/head-to-tail...

Reported herein is the first metal-free oxidative [4 + 2] coupling of o-phenylenediamines with various alkenes. Differing from known strategy that hinged on reactive π-allyl Pd intermediates restrained allylic alcohol/acetate and diene substrates, this method features easy accessibility starting materials, step economy, benign reaction conditions, more importantly broad C-C double bonds (styrenes, vinyl (thio)ethers, benzofurans, indoles) diastereospecificities. Mechanistic studies suggest...

We provide an effective method to create DNA nanostructures below 100 nm with defined charge patterns and explore whether the density location of charges affect cellular uptake efficiency nanoparticles (NPs). To avoid spontaneous neutralization, negatively charged polymer nanopatterns were first created by in situ polymerization using photoresponsive monomers on origami. Subsequent irradiation generated positive immobilized polymers, achieving precise positively surface. Via this method, we...

The first regiospecific catalytic intermolecular assembly of 2,2-disubstituted indolines has been developed. This protocol is based on a ligand and directing group free, iron-catalyzed radical [3 + 2] process, allowing efficient coupling different N-sulfonylanilines with various α-substituted styrenes. Preliminary mechanistic studies elucidated the mechanism involving reactive versatile anilino importance iron complex as Lewis acid, rendering both reactivity regiospecificity this transformation.

Herein we develop a novel micellar catalytic system based on amphiphilic bifunctional iodide salts for oxidative intramolecular α‐oxygenation and α‐amination of carbonyl substrates in water, thus enabling unified benign synthesis various 2‐oxindoles containing spirotetrahydrobenzofurans, spiroisochromanones, spiroindolines spirolactones. Notably, the terminal oxidant H 2 O produced water as only by‐product. The excellent recyclability aqueous medium catalyst further highlights synthetic...

π-Extended benzofuro[2,3-<italic>b</italic>]indoles were efficiently constructed from readily available <italic>p</italic>-hydroquinone esters and indoles <italic>via</italic> aerobic oxidation.

A novel synergistically catalyzed thia-aza-Prins cyclization of alkenylamines with disulfides is reported, rendering the first synthesis sulfenylated 1,3-oxazinanes and oxazolidines in good to high yields. Importantly, DMSO serves simultaneously as a reaction medium surrogate for formaldehyde. Mechanistic studies provide evidence that actions CuBr2 situ formed sulfinic acids Lewis acid Brønsted catalyst, respectively, catalyze these processes.

Abstract Reported here is the first catalytic atroposelective electrophilic amination of indoles, which delivers functionalized atropochiral N ‐sulfonyl‐3‐arylaminoindoles with excellent optical purity. This reaction was furnished by 1,6‐nucleophilic addition to p ‐quinone diimines. Control experiments suggest an ionic mechanism that differs from radical pathway commonly proposed for 1,6‐addition quinones. The origin selectivity investigated through computational studies. Preliminary studies...

Complex <bold>2</bold> can induce nuclear and mitochondrial dual damage in HCT116 cells also apoptosis.

Selective labeling of the protein interest (POI) in genetically unmodified live cells is crucial for understanding functions and kinetics their natural habitat. In particular, spatiotemporally controlled installation labels on a POI under light control without affecting original activity high demand but tremendous challenge. Here, we describe novel ligand-directed photoclick strategy endogenous proteins cells. It was realized with designer reagent skillfully integrating photochemistries...

Investigation of N-heterocycle transition metal complexes has led to the discovery metal-based antitumor agents. Herein, two binuclear complexes, [Cu(p-4-bmb)(Ac)2]2 (1) and [Co(p-4-bmp)Cl2]2 (2), were prepared characterized. The interactions 1 2 with calf thymus (CT)-DNA bovine serum albumin (BSA) detected by absorbance emission spectroscopy. bind CT-DNA via an intercalative mode show moderate affinity BSA. Both exhibited remarkable DNA cleavage activity. MTT assay demonstrated that higher...

A formal dual C(sp 2 )–H cross-dehydrogenative C–O bond formation reaction between phenols and naphthylamine derivatives to construct diaryl ethers has been developed under mild conditions.

An efficient iron-catalyzed radical cross-dehydrogenative aromatic C–H amidation provides a straightforward access to structurally diverse diarylamine derivatives incorporating benzofuran/benzothiophene motifs.

Two novel porous metal–organic frameworks (MOFs) with {M18(Hbtib)36} (M = Ni(II), Zn(II)) as the basic building unit, namely, [Ni(Hbtib)2]n (1) and [Zn(Hbtib)2·H2O]n (2) [H2btib 4-((2-butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-enyl)-1H-imidazol-1-yl)methyl)] were synthesized using solvothermal reactions. Gas adsorption (N2, H2, CO2 CH4) studies show that desolvated solid 1 is a highly effective absorbent for over CH4 at 273 298 K. The results suggest has potential application in gas...

We report the molecular design of a novel multifunctional reagent and its application for light-controlled selective protein labeling. This molecule integrates functions protein-ligand recognition, bioconjugation, ligand cleavage, photoactivation by merging photochemistries 2-nitrophenylpropyloxycarbonyl 3-hydroxymethyl-2-naphthol with an affinity fluorescein. Highly electrophilic o-naphthoquinone methide was photochemically released underwent proximity-driven labeling interest (e.g.,...

It is necessary for clinicians to be aware of a rare but possible acute respiratory distress syndrome (ARDS) complication caused by multiple wasp stings. Severe ARDS has high mortality rate no specific pharmacotherapies have been identified date. This case study presents the first severe stings, treated successfully with extracorporeal membrane oxygenation (ECMO). also emphasizes effectiveness early ECMO treatment persistent hypoxemia.A 24-year-old woman was admitted emergency department...

Glutathione peroxidase 4 (GPx4) is the membrane in mammals that essential for protecting cells against oxidative damage and critical ferroptosis. However, no live cell probe currently available to specifically label GPx4. Herein, we report both inhibitory noninhibitory fluorescent turn-on probes specific labeling of GPx4 cells. With these probes, expression levels degradation kinetics could be visualized, their real-time responses cellular selenium availability were revealed. These also...

Cochineal red is an organic compound widely used in food, cosmetics, pharmaceuticals, textiles, and other fields due to its excellent safety profile. Poisoning caused by eating foods containing cochineal rare, repeated atrial arrhythmia poisoning even rarer.An 88-year-old Asian female patient was admitted hospital a disturbance of consciousness. Twelve hours prior presentation, the consumed 12 eggs over period 2 h. At coma had score 6 on Glasgow Coma Scale (E2 + VT M4). The patient's skin...