A5110987362- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Celiac Disease Research and Management
- Dermatologic Treatments and Research
- Corneal Surgery and Treatments
- Autoimmune Bullous Skin Diseases
- Infrared Thermography in Medicine
- Wnt/β-catenin signaling in development and cancer
- Fibroblast Growth Factor Research
- Surgical site infection prevention
- Biomarkers in Disease Mechanisms
- Retinal and Macular Surgery
- Mechanical Circulatory Support Devices
- Mast cells and histamine
- Medical and Biological Ozone Research
- Inflammatory Biomarkers in Disease Prognosis
- Folate and B Vitamins Research
- Proteoglycans and glycosaminoglycans research
- Connective Tissue Growth Factor Research
- Wound Healing and Treatments
- Inflammatory mediators and NSAID effects
- Vitamin D Research Studies
- Esophageal and GI Pathology
Mersin Üniversitesi
2007-2025
Massachusetts Eye Research and Surgery Institute
2025
Sebelas Maret University
2024
Hacettepe University
2017-2024
Mustafa Kemal University
2024
University College London
2018-2022
Ankara Yıldırım Beyazıt University
2022
Sağlık Bilimleri Üniversitesi
2022
Afyon Kocatepe University
2022
The Royal Free Hospital
2018-2020
To describe the associations between autoantibodies, clinical presentation, and outcomes among patients with systemic sclerosis (SSc) in order to develop a novel SSc classification scheme that would incorporate both antibodies cutaneous disease subset as criteria.Demographic characteristics, including subset, time of organ complication onset, autoantibody specificities, were determined cohort subjects. Survival analysis was used assess effect autoantibodies on death.The study included 1,325...
Systemic sclerosis (SSc) is characterized by the presence of SSc-specific or SSc-associated antibodies (SSc-Abs): anti-topoisomerase I (ATA), anti-centromere (ACA), anti-RNA polymerase III (ARA), anti-U3RNP (U3RNP), anti-U1RNP (U1RNP), anti-PmScl (PmScl), anti-Ku (Ku) and anti-Th/To (Th/To), each being associated with specific clinical features prognosis. The detection more than one SSc-Abs in SSc patients rare only few data about these patients' phenotype available. aim our study was to...
Distributed generation models have started to be seen intensively in distribution networks with technological developments. The increase distributed resources has brought changes the grid. Problems such as improper operation of grid protection systems and imbalances load flow emerged. In this article, short circuit analyses a low voltage network source are performed effects on predicted. Results predictions regarding optimum operating conditions presence been obtained. Real-time power...
Objectives The objective of this study was to report the experience with rituximab treatment in a case series patients long-standing systemic sclerosis–associated interstitial lung disease (SSc-ILD). Methods We reviewed charts 197 SSc patients. Fourteen who received for SSc-ILD participated analysis. Pulmonary function tests, high-resolution thorax computed tomography and modified Rodnan skin scores were evaluated at baseline end follow-up. Results Median age 53.2 years (interquartile range,...
Purpose Pterygium is a proliferative, inflammatory, and invasive ocular surface disease associated with excessive ultraviolet radiation exposure has several tumor-like characteristics. Cyclooxygenase-2 (COX-2) an inducible enzyme recently increased expression of the was found in many cancers premalign lesions. This study conducted to identify COX-2 pterygium tissues. Methods Immunohistochemical staining using primary antibody for performed on 30 specimens (20 without recurrence 10 which...
To explore the frequency and clinical associations of radiologic pleuroparenchymal fibroelastosis (PPFE) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).In this single-center retrospective study, high resolution computed tomography (HRCT) images 105 SSc-ILD were examined for presence PPFE. Demographic, clinical, laboratory, pulmonary function test (PFT) data without PPFE compared.PPFE was detected 19 (18.1%) ('definite PPFE' 13 'consistent 6 patients)....
In patients with systemic sclerosis (SSc) gastrointestinal (GI) involvement, nutritional status and medications may lead to cobalamin (Vit B12) deficiency. We aimed determine the frequency potential causes of Vit B12 deficiency in SSc patients.We conducted a cross-sectional analysis 62 single center 1 year period. Medical history physical examination were reevaluated. Data about organ involvements obtained from hospital file records. The was assessed Malnutrition Universal Screening Tool...
Deterioration in pulmonary gas exchange occurs after cardiovascular surgery involving cardiopulmonary bypass (CPB) (1–6). A cohort study reported a 12% incidence and 4.4% mortality 1,461 patients with early onset acute dysfunction CPB, which was defined on the patient’s arrival at intensive care unit (ICU) need for mechanical ventilation Pao2/inspired oxygen fraction (Fio2) ratio of <150 mm Hg (1). We report successful treatment life-threatening hypoxemic respiratory failure venoarterial...
Background/aim: To investigate the frequency and clinical relevance of an extended autoantibody (ab) profile in patients with SSc. Materials Methods: In this cross-sectional study, serum from 100 consecutive was subjected to indirect immunofluorescence (HEp-20-10/primate liver mosaic) Systemic Sclerosis Profile by EUROIMMUN (Lübeck, Germany) evaluate ANA autoantibodies against 13 different SSc less than three years. Results: 93 were positive for (IIF). The prevalence Anti-Scl70 ab 41%,...
<h3>Background:</h3> Gastrointestinal tract (GIS) involvement is a leading cause of morbidity in systemic sclerosis (SSc). Non-invasive biomarkers are needed for GI involvement. The role anti-muscarinic 3 receptor (anti-M3R) antibodies the pathogenesis has been demonstrated. <h3>Objectives:</h3> aim this study was to investigate relationship between uptake characteristics and serum anti-M3R SSc patients. <h3>Methods:</h3> This conducted with 41 patients 5 healthy controls. complaints all...
Alzheimer's disease (AD) is a neurodegenerative related to elderly with subtle onset and progressive impairment of behavior cognitive functions that projected increase without medical breakthroughs. Recent medication effectiveness limited, only symptomatic treatment available, none are curative, variably palliative. Studies suggest an association between gut health progression through the “microbiome-gut-brain axis”. A scoping review was conducted further explore positive effects probiotics...
To investigate the frequency and clinical relevance of an extended autoantibody profile in patients with systemic sclerosis (SSc).
Difficulty in the clinical practice of stem cell therapy is often experienced achieving desired target tissue differentiation and migration cells to other compartments where they are destroyed or die. This study was performed evaluate if mesenchymal (MSCs) may differentiate into types when injected after combined with an injectable cryogel scaffold investigate this help preventing from passing different compartments. MSCs were obtained fat rabbits as autografts nuclei cytoplasms these...
Systemic sclerosis (SSc) is a rare, potentially destructive systemic autoimmune disease characterized by organ fibrosis and vasculopathy. Netrin-1 associated with angiogenesis, inflammation, apoptosis. To assess the level of serum netrin-1 in SSc patients capillary abnormalities to evaluate its relation manifestations. This study investigated relationship between 56 58 matched control. The modified Rodnan skin score (mRss) was used thickness. Serum quantitatively measured using an...
<h3>Background</h3> Vitamin B12 (Vit B12) deficiency is a common condition, which can be manifested with non-specific clinical features or neurological and/or haematological abnormalities in severe cases. In systemic sclerosis (SSc) gastrointestinal involvement (GI), nutritional status and medications may lead to Vit deficiency. <h3>Objectives</h3> We aimed investigate the frequency of its determinants SSc patients. <h3>Methods</h3> Sixty-two (90.3% female) patients were enrolled study. The...
<h3>Background</h3> Interstitial lung disease (ILD) is the leading cause of mortality in systemic sclerosis (SSc) patients. Treatment options are rather limited SSc associated ILD (SSc-ILD). <h3>Objectives</h3> Objective this study was to report experience RTX treatment a series patients with longstanding SSc-ILD whom unsatisfactory response functions noted under conventional treatments. <h3>Methods</h3> We retrospectively reviewed charts 197 evaluated between April 2015 and November 2016....
<h3>Background:</h3> Scleroderma is a connective tissue disease that characterized by fibrosis of the skin.The modified Rodnan Skin Score (mRSS) measure generally used to assess skin thickness in patients with scleroderma.Data on effectiveness mRSS training courses differ literature. <h3>Objectives:</h3> The objective our study was evaluate course rheumatology fellows departments. <h3>Methods:</h3> included 6 from departments rheumatology.Participants were given 1-hour-long theoretical...
Objective: Sarcoidosis is a disease which courses with noncaseating granulomas, and within the pathophysiology of abnormal immune response, inflammation oxidative stress are held responsible. Lungs organs it mostly involves lung involvement radiologically divided into stages. The present research aims to evaluate relationship between stage sarcoidosis carotid intima media thickness measurement one indicators subclinical atherosclerosis.
<h3>Background</h3> Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has diverse and wide array of clinical presentations ranging from asymptomatic to disease. The exact pathophysiological mechanism COVID-19 is still obscure; however, unrestrained immune response, exaggerated systemic inflammation, endothelial activation, vascular damage are implicated in its pathogenesis similar sclerosis (SSc) autoimmune diseases [1-2]....
one of characteristic nailfold changes or SSc autoantibodies is required.If only subjective evidence Raynaud's phenomenon present (i.e.patient report only) then both are required.The proposed modifications the use thermographic parameters as objective phenomenon, required in 2001 criteria.Methods: This was a retrospective study 158 patients with consultant rheumatologist diagnosis SSc.The following inclusion criteria were used for patient selection: patient's first clinic letter and...