A5074565282- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Kawasaki Disease and Coronary Complications
- Medical Imaging and Pathology Studies
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Pulmonary Hypertension Research and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders Research
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- Human Health and Disease
- Renal and related cancers
- Inflammation biomarkers and pathways
- Advanced Drug Delivery Systems
- Polyomavirus and related diseases
- Neuroscience and Neuropharmacology Research
- Dermatological and COVID-19 studies
- Dermatological and Skeletal Disorders
- Phagocytosis and Immune Regulation
- Hepatitis Viruses Studies and Epidemiology
- Salivary Gland Disorders and Functions
- Psoriasis: Treatment and Pathogenesis
Istanbul University
2017-2024
Center for Rheumatology
2023
Czech Academy of Sciences, Institute of Physiology
2015
In this study, we aimed to screen 31 genes (C1QA, C1QB, C1QC, C1R, C1S, C2, C3, TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, DNASE1, DNASE1L3, PRKCD, ACP5, SLC7A7, IFIH1, TMEM173, ISG15, CYBB, FAS, FASLG, KRAS, NRAS, MAN2B1, PEPD, PTPN11, RAG2, and SHOC2), that have categorized under the umbrella term "monogenic lupus" using a targeted next-generation sequencing (NGS) panel in 24 individuals with early-onset (≤10 years of age) systemic lupus erythematosus (SLE) patients late-onset (>10...
This study aimed to investigate whether patients regularly using colchicine or hydroxychloroquine (HCQ) have an advantage of protection from coronavirus disease 2019 (COVID-19) developing less severe disease. Patients who were taking HCQ for a rheumatic including Familial Mediterranean Fever, Behçet's syndrome, Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Sjogren's as well their healthy household contacts the control group, included in study. The clinical data regarding COVID-19...
Staphylococcus aureus is a rare cause of postinfectious glomerulonephritis, and Staphylococcus-related glomerulonephritis primarily occurs in middle-aged or elderly patients. Patients with also present hematuria, proteinuria varying degrees, rising serum creatinine levels, and/or edema. The severity renal insufficiency proportional to the degree proliferation crescent formation. Here, we diabetic patient admitted history 1 week left elbow pain. Laboratory results revealed that erythrocyte...
Background/aim: B-cell depletion with rituximab (RTX) is widely used as a rescue therapy in patients systemic sclerosis (SSc). The aim herein was to analyze the progress of disease-related outcomes after RTX severe SSc patients. Materials and methods: Included this study were 27 who followed-up between 2012 2020 received at least 1 cycle for active disease, despite receiving standard immunosuppressives (ISs). In addition European Scleroderma Study Group Trials Research activity scores,...
ABSTRACT Objectives We aimed to analyze the prevalence, mortality, and prognostic factors in systemic sclerosis (SSc) patients with pulmonary hypertension (PH) or without interstitial lung disease (ILD). Methods The associations between mortality demographics, transthoracic echocardiography, right heart catheterization (RHC), functional parameters at baseline, treatment modalities two groups; arterial (PAH, PH significant ILD) + ILD were evaluated. Results mean age of was 56.6±13.5 (range:...
The article presents the results of studying etiological structure and clinical features acute intestinal infections (AII) in young children Baku, Azerbaijan. In most cases, disease has a viral etiology proceeds form gastroenteritis. At same time age groups 6—12 months 1—3 years life, 72.72% cases have mixed (usually viral-viral), with predominance rotavirus infection. Taking into account obtained results, it is necessary for all early AII, addition to routine diagnostics, conduct research...
Background Serious infections are more frequently seen in patients with inflammatory rheumatic diseases, being treated immunosuppressive or biologic disease-modifying antirheumatic drugs (b-DMARDs). Potential harmful effects of as well b-DMARDs were a major concern during the early phases Coronavirus disease 2019 (COVID-19) pandemic, and preliminary data documented worse outcome COVID-19 associated B cell depleting treatments (1). On other hand, limited information has been shared about...
Objective Hyperinflammation (HI) that develops in week 2 of COVID‐19 contributes to a worse outcome. Because laboratory findings can be relatively mild, the available criteria for classification hemophagocytic lymphohistiocytosis or macrophage activation syndrome are not helpful. Methods Our study included discovery cohort patients from Turkey with symptomatic who were followed up while hospitalized during initial wave and replication later period, all whom required oxygen support received...
Background In systemic sclerosis (SSc), studies showed that permenant organ damage may exist very early in the disease course. Objectives To reveal differences between diffuse cutaneous and limited SSc (dcSSc lcSSc) patients regarding progress of related over time. Methods Medical records consecutive 210 patients(91.9% women) who fulfilled classification criteria had a follow-up period at least 12 months were retrospectively evaluated. ‘Scleroderma Clinical Trials Consortium Damage Index‘...
<h3>Background</h3> Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has diverse and wide array of clinical presentations ranging from asymptomatic to disease. The exact pathophysiological mechanism COVID-19 is still obscure; however, unrestrained immune response, exaggerated systemic inflammation, endothelial activation, vascular damage are implicated in its pathogenesis similar sclerosis (SSc) autoimmune diseases [1-2]....
<h3>Background</h3> Some specific autoantibodies were known to be associated with cutaneous subtype, type of organ involvement and prognosis in systemic sclerosis (SSc). <h3>Objectives</h3> The aim our study was evaluate the impact autoantibody profile on course SSc regarding new over time. <h3>Methods</h3> data 206 consequitive patients (189 women) who followed up at least 12 months retrospectively analyzed. Associations between (anti-nuclear antibody (ANA) (27.7%, n=57), anti-Scl70 (47.1%,...
<h3>Background</h3> Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis with high mortality. Although new drugs and treatment strategies developed in the last years, prognosis prevalent patients has not been sufficiently improved. <h3>Objectives</h3> We aimed to analyze prevalence, mortality, prognostic factors SSc-PAH from our single-center SSc cohort. <h3>Methods</h3> retrospectively evaluated association between mortality demographics, transthoracic...
Background: Treatment options for systemic sclerosis (SSc) remain limited especially in severe skin, lung and musculoskeletal involvements. B-cell targeted therapy with anti-CD20 Rituximab (RTX), is widely available, reports from case series are encouraging as a rescue might have an improving effect on organ involvement SSc. Objectives: We aimed to retrospectively analyze the efficacy safety of rituximab (RTX) courses patients who were refractory standard immunosuppressive treatment....
Background: Proximal scleroderma is the major criterion in both 1980 and 2013 classification criteria for sytemic scleroris (SSc). ACR(1980) included digital lesions bibasiler fibrozis, nonetheless ACR/EULAR(2013) based on a scoring system including lesions, telangiectasia, abnormal nailfold video-capillaroscopy(NVC), PAH, Raynaud’s specific autoantibodies. Objectives: We aimed to implement Turkish SSc kohort evaluate contribution of non-skin manifestations, NVC Methods: A consecutive...
Studies have been carried out to determine the mechanisms of effect vitamin D deficiency on clinical manifestation, course and prognosis intestinal diseases in children Aral Sea region, as well develop substantiated methods corrective therapy. Based data obtained, it was concluded that analysis results dynamics observation will make possible predict outcome disease, evaluate effectiveness therapy, and, if.
Background: Evaluating disease activity and severity in systemic sclerosis (SSc) is crucial to define the patients who are candidate for treatment options. Objectives: We aimed investigate relationship between SSc a large cohort. Methods: This cross-sectional prospective analysis of 278 (253 females) fulfilling ACR/EULAR (2013) classification criteria SSc. Disease were calculated seperately cutaneous subsets (EscSG Medsger). The grouped as inactive if EscSG score=0, mildly active...
Background Nintedanib, an intracellular inhibitor of tyrosine kinases, has been recently approved for interstitial lung disease associated with systemic sclerosis (SSc-ILD). Nintedanib shown antifibrotic and antiinflammtory effects in animal models fibrosing ILDs. Objectives We aimed to evaluate clinical charcteristics progressive SSc-ILD patients receiving anti-fibrotic therapy who were resistant standart immunosuppressives (ISs) adverse events during treatment period this cohort. Methods...
Background: Hyperinflammation with features of cytokine storm developing in 2nd week COVID-19 contributes to the worse outcome. Because relatively milder inflammatory findings compared other storms, available criteria for classification hemophagocytic lymphohistiocytosis or macrophage activation syndrome (MAS) could not be helpful.Methods: Discovery cohort included symptomatic patients, who were followed at hospital during initial wave. Replication consisted hospitalized patients from a...
Background: Infection is a remarkable cause of morbidity and mortality in patients with SLE. Objectives: We aimed to determine the clinical course COVID-19 infection our SLE factors affecting this Methods: (2012 SLICC criteria) diagnosed by positive PCR test and/or typical findings lung involvement CT (computed tomography) imaging were included. Data regarding cumulative laboratory characteristics, histopathology results, autoantibody profiles, immunsuppressives damage (SLICC index/ SDI ))...