A5059190185- Inflammasome and immune disorders
- Oral microbiology and periodontitis research
- Systemic Lupus Erythematosus Research
- interferon and immune responses
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Connective tissue disorders research
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Dysphagia Assessment and Management
- Parkinson's Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 detection and testing
- IL-33, ST2, and ILC Pathways
- Oral Health Pathology and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Surgical Sutures and Adhesives
- Plant Virus Research Studies
- Metabolism, Diabetes, and Cancer
- Medical Imaging and Pathology Studies
- Salivary Gland Disorders and Functions
- Hypertrophic osteoarthropathy and related conditions
- Gout, Hyperuricemia, Uric Acid
- Dental Radiography and Imaging
Istanbul Medeniyet University
2018-2025
Istanbul University
2025
Istanbul University-Cerrahpaşa
2025
Ümraniye Eğitim ve Araştırma Hastanesi
2020
Sağlık Bilimleri Üniversitesi
2020
Istanbul Technical University
2017-2019
Marmara University
2018
Maltepe University
2018
Streptococcus mutans, is considered the main microbial etiological agent of dental caries, therefore it has been proposed as a useful predictor caries risk well target for prevention strategies. We aimed to compare genomic characteristics S. mutans strains isolated from individuals with high and low risk, in order determine their genotypic features related adults. A total 25 isolates, obtained saliva 13 volunteers activity 12 caries-free individuals, were analysed using whole-genome...
OBJECTIVE:Turkey is one of the latest countries that COVID-19 disease was reported, with first case on March 11, 2020, and since then, Istanbul became epicenter pandemic in Turkey.Here, we reveal sequences virus isolated from three different patients various clinical presentations. METHODS:Nasopharyngeal swab specimens were tested positive for by qRT-PCR.Viral RNA extraction performed same samples.Amplicon based libraries prepared sequenced using Illumina NextSeq platform.Raw sequencing data...
Abstract Aim To detect the unknown components of oral microbiome and effects root canal treatment in a Turkish population to evaluate changes microbial diversity canals before after treatment. Methodology Single‐rooted central lateral maxillary incisors with one were chosen from 20 patients. Baseline samples intact intracanal microbiota collected permanent teeth necrotic pulps using sterile paper points. After preparation, filled calcium hydroxide paste for 7 days. Calcium was removed 2.5%...
The oral microbiome is maintained by host- and microbe-derived factors. A shift in microbial composition, as a result of diseases related to the immune system, most important step development dental diseases. aim this study was investigate composition patients with Kostmann syndrome, who have severe neutropenia, compared healthy children.A group nine syndrome controls participated. After clinical investigation, DNA from stimulated saliva specimens examined high-throughput sequencing V3-V4...
This study aimed to investigate whether patients regularly using colchicine or hydroxychloroquine (HCQ) have an advantage of protection from coronavirus disease 2019 (COVID-19) developing less severe disease. Patients who were taking HCQ for a rheumatic including Familial Mediterranean Fever, Behçet's syndrome, Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Sjogren's as well their healthy household contacts the control group, included in study. The clinical data regarding COVID-19...
Objective: Autosomal recessive cutis laxa type IIA (ARCL2A) is a rare congenital disorder characterized by loose and elastic skin, growth developmental delay, skeletal anomalies.It caused biallelic mutations in ATP6V0A2.Those lead to increased pH secretory vesicles thereby impaired glycosyltransferase activity organelle trafficking.We aimed identify the genetic molecular cause of unexpected hematological findings Turkish family. Materials Methods:We performed clinical, genetic, histological...
Abstract There are recent studies which aimed to detect the inheritance on etiology of dental caries exploring oral composition. We present data microbiota and its relation with other factors in monozygotic (MZ) dizygotic (DZ) twin children. Following clinical investigation, DNA samples were collected isolated from saliva 198 patients (49 MZ 50 DZ twins) an average age 9.7 ± 2.7 years. Salivary bacterial analysis was performed using high throughput amplicon sequencing method targeting V3-V4...
<h3>Background</h3> Takayasu arteritis (TA) is an inflammatory large vessel vasculitis affecting mainly aorta and its branches. Inflammation in vessels causes thickening of walls, fibrosis, dilatation nonspecific symptoms such as fever, hypertension arthralgia. It a rare disorder with unknown etiology the worldwide incidence 0.4 to 2.6 per million. <h3>Objectives</h3> We studied three consanguineous families consisting two affected daughters each their healthy parents order identify disease...
Objective: Autosomal recessive cutis laxa type IIA (ARCL2A) is a rare congenital disorder characterized by loose and elastic skin, growth developmental delay, skeletal anomalies.It caused biallelic mutations in ATP6V0A2.Those lead to increased pH secretory vesicles thereby impaired glycosyltransferase activity organelle trafficking.We aimed identify the genetic molecular cause of unexpected hematological findings Turkish family. Materials Methods:We performed clinical, genetic, histological...
Objective: Glucose transporter-1 deficiency syndrome (GLUT1- DS) is defined as a metabolic encephalopathy that associated with heterozygous and usually de novo pathogenic variations in the SLC2A1 (solute carrier family2 member1) gene. Materials Methods: In this study, all coding exons neighboring intronic regions of were Sanger sequenced 12 patients clinically suspected GLUT1-DS. For revealed after sequencing segregation analysis, we also performed genome wide Single Nucleotide Polymorphism...
Amaç: Bu çalışmada mikroRNA (miRNA) hedeflerinin spesifik olarak belirlenmesi ve ekspresyon ölçümünün yapılmasına yönelik tek basamaklı ters transkripsiyon kantitatif polimeraz zincir reaksiyonu (RT-qPZR) yönteminin, seçilen iki farklı miRNA (hsa-miR-145-5p hsa-miR-146a-5p) için araştırılması sürecin optimizasyonu amaçlanmıştır. Gereç Yöntem: RNA eldesi HEK293T hücre hattından yapılmıştır. Çalışmada her hedefi uygun primerler tasarlanmış, RT-qPZR yöntemi ile optimizasyon işlemi...
<h3>Background</h3> Takayasu arteritis (TA) is a rare chronic inflammatory disease of the aorta and its major branches, seen predominantly in females. Its etiology unknown, however, there growing body evidence to suggest genetic contribution pathogenesis disease: a) The relatively frequent Asia, b) Several familial cases TA have been published (1) even, autosomal recessive inheritance pattern has suggested (2), c) Genetic association with HLA-B*52 across multiple ethnicities confirmed (3),...
<h3>Background</h3> There are reports showing Three Prime Repair Exonuclease 1 (<i>TREX1</i>) mutations in atypical Systemic Lupus Erythematosus (SLE) patients. <h3>Objectives</h3> Here we report a family with SLE and Antiphospholipid Syndrome (aPL) who positive for <i>TREX1</i> mutation complicated AA amyloidosis <h3>Methods</h3> DNA samples were extracted from peripheral blood of two affected (mother daughter) unaffected individuals the same family. Exome sequencing was performed daughter...
Summary COVID-19 is a viral respiratory disease caused by SARS-CoV-2 infection. Global efforts of genomic surveillance the virus give chance to track spread pandemic. emergence some mutations called attention and various studies have been suggested about increased infectivity virus. Herein, we sequenced genomes isolated from 184 patients in Istanbul analyzed clinical metadata for investigation any mutation which affects course host. We did not detect affecting outcome our cohort. Besides,...