Abstract Objective The skin pathergy test (SPT) is an important tool in the diagnosis of Behçet disease (BD), but its decreasing sensitivity over years has resulted less frequent use clinical practice. This study aimed to improve SPT without compromising specificity. Methods BD patients, patients with other inflammatory diseases, recurrent aphthous stomatitis, and healthy controls comprised group. was conducted using 20G needle 21G lancet pricks, or additional application 23-valent...

Background/aim: B-cell depletion with rituximab (RTX) is widely used as a rescue therapy in patients systemic sclerosis (SSc). The aim herein was to analyze the progress of disease-related outcomes after RTX severe SSc patients. Materials and methods: Included this study were 27 who followed-up between 2012 2020 received at least 1 cycle for active disease, despite receiving standard immunosuppressives (ISs). In addition European Scleroderma Study Group Trials Research activity scores,...

Background: Patients with systemic lupus erythematosus (SLE) can present acute disease flares/exacerbations during pregnancy and postpartum period. 1 These flares cause adverse outcomes (APO). Objectives: In this study, our pregnant SLE cohort, which was under medical surveillance of both Rheumatology Gynecology Obstetrics departments analyzed. We intended to determine the effects on activity correlation between outcomes. Methods: 168 data involving 136 patients meeting ACR criteria were...

Bektaş, Murat MD; Ağargün, Besim Fazil Torun, Ege Sinan Çatma, Yunus Beşişik, Selman Fatih Nalçaci, Meliha Yegen, Gülçin Yalçinkaya, Yasemin Esen, Bahar Artim Gül, Ahmet Öcal, Mahdume Lale İnanç, MDAuthor Information

Background: Systemic AA amyloidosis is a serious and life-threatening complication of chronic inflammatory diseases such as rheumatoid arthritis, spondyloarthritis (SpA), periodic fever syndromes. While most common cause Familial Mediterranean Fever; Ankylosing Spondylitis (AS) another frequent in Turkey. Objectives: We aimed to evaluate the response secukinumab (SEC) treatment three patients with AS (AS-AA) our tertiary referral centre. Methods: retrospectively evaluated who fulfilled...

Spondiloartritler aksiyel tutulum, periferik artrit, entezit, daktilit yanı sıra psöriyazis, üveit ve enflamatuvar barsak hastalığı (İBH) gibi ekstrartiküler tutulumlarla karakterize bir kronik hastalık grubudur

<h3>Background</h3> CD163 is a glycosylated membrane protein expressed in monocytes and macrophages that phagocytize the hemoglobin/haptoglobin complex. As result of proinflammatory stimuli, shedded from cell becomes soluble CD163. Therefore, it has been shown serum (s) urine (u) levels increase acute or chronic inflammatory diseases. sCD163 uCD163 are considered as potential biomarkers reflecting disease activity patients with systemic lupus erythematosus (SLE). <h3>Objectives</h3> We aimed...

<h3>Background:</h3> BAFF and APRIL are cytokines involved in B cell development they take place the pathogenesis of SLE. <h3>Objectives:</h3> The aim this study was to investigate relationship between serum BAFF/APRIL levels with clinical features disease activity SLE patients. <h3>Methods:</h3> We included 79 patients (ACR criteria) 27 healthy controls into study. Serum were assessed by ELISA. In 19 active at time assessment reassessed least 6 months later (mean 7.8 months) evaluated...

<h3>Background</h3> ANCA associated vasculitides (AAV) comprise an important subset of small vessel with a multifactorial pathogenesis, which is considered to be the interaction genetic and environmental factors. Certain HLA Class 2 alleles have been reported among risk factors for AAV from different geographic regions such as Europe Asia (1,2). <h3>Objectives</h3> In this study, we aimed analyse distribution genotypes series Turkish patients in comparison healthy subjects previously data...

Background: Adjusted global antiphosholipid syndrome score (aGAPSS) is the simplified version GAPSS that was recently developed to assess thrombotic risk by consideration of antiphospholipid antibody (aPL) profile and conventional cardiovascular factors. Objectives: The aim this study evaluate validity aGAPSS in predicting thrombosis extra-criteria manifestations our (APS) cohort. Methods: Ninety-eight patients with APS were classified according clinical as vascular (VT), pregnancy morbidity...

Background: Hydroxychloroquine (HCQ) is an immunomodulatory drug that has been shown to improve disease activity in systemic lupus erythematosus (SLE). However, retinal toxicity important concern. Objectives: In this study we sought evaluate the effect of HCQ on and damage patients with SLE whom was discontinued due whether it could be restarted by a detailed ophthalmologic examination. Methods: Patients who met SLICC classification criteria were for at least 3 years after reaching Lupus Low...

Background: Pregnancies of patients with systemic lupus erythematosus (SLE) can be risky both for the mother and fetus because disease activity pregnancy complications. 1 Objectives: In this study, we evaluated risk factors related to adverse outcomes (APO) in our pregnant SLE cohort who were followed up by Rheumatology Obstetrics Gynecology departments at university. Methods: 168 data analyzed from 136 fulfilled ACR classification criteria SLE. The course pregnancies monitored...

Background: ANCA-associated vasculitis (AAV) is a multisystemic autoimmune disease with high mortality and morbidity. Objectives: We aimed to present the long-term follow-up results of our cohort. Methods: Data patients who fulfilled Chapell Hill Consensus Criteria followed up at least 6 months between 1999-2019 were analyzed. A standard form including damage index (VDI) was used. Multivariable analysis performed by using logistic regression. Results: Long-term data available for 197 (%53.8...

Background: Serious infections (SI) are one of the main complications in patients with ANCA associated vasculitis (AAV). Objectives: We planned to investigate prevalence, features and risk factors SI our AAV cohort during follow-up. Methods: Outpatient hospital data diagnosed granulomatous polyangiitis (GPA), microscopic (MPA) eosinophilic (eGPA) between 1999 2019 according Chapel Hill Consensus Criteria followed up at least 6 months clinic were evaluated. Development sepsis, requirement for...

Background: Development of organ damage is a major concern in patients with systemic vasculitis. Treatment may also contribute to this important outcome. Scoring systems has been developed evaluate vasculitis and specifically for large vessel (1). Objectives: We aimed investigate permanent determining factors our giant cell arteritis GCA cohort. Methods: Organ detected at the time diagnosis / or follow-up irreversible least 3 months followed up between 1998-2018 were recorded by using...

Background: AA amyloidosis has been associated with uncontrolled chronic inflammatory diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), bowel disease (IBD) and hereditary periodic fever syndromes, the most common cause is familial Mediterranean (FMF) in Turkey. Objectives: We herein aimed to evaluate clinical laboratory characteristics treatment responses of patients retrospectively a tertiary referral center. Methods: Study group was consisting biopsy proven...

Background: The prevalence of giant cell arteritis (GCA) in Turkey has been reported lower than other European countries and the information on clinical patterns, diagnostic modalities, treatment prognosis GCA are limited (1). Objectives: We aimed to analyse our cohort from a large outpatient clinic for last 20 years. Methods: Data patients followed up at least 6 months vasculitis between 1998 2018 evaluated retrospectively according EULAR research recommendations (2). Chi-square, students...

Background: The prevalence of SLE pulmonary involvement varies depending on several factors, including diagnostic methods [1]. Objectives: We aimed to determine the frequency with different in a single center cohort. Methods: 300 patients were included. Chest x-ray (CXR), lung spirometry, carbonmonoxide diffusion test (DLCOc) and echocardiography performed. High resolution thorax computed tomography (HRCT) was done for definite diagnosis interstitial disease (ILD) whilst diagram...

Background: Retinol binding protein 4 (RBP4) is a plasma retinol transporter that transports from liver to periphery. RBP4 has been studied as biomarker in metabolic and neoplastic conditions, however its association with inflammation not clear. Serum amyloid A (SAA), another protein, known sensitive of familial Mediterranean fever (FMF) other autoinflammatory disorders. C-reactive (CRP), erythrocyte sedimentation rate (ESR) SAA are commonly used acute phase reactants, but they successful...

Background: Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disorder caused by the MEFV gene variants. Although association between FMF and spondyloarthritis (SpA) has previously been reported, clinical laboratory features of patients with SpA have not defined in detail. Objectives: We aimed to evaluate characteristics, disease outcome biologic responses FMF+SpA compared only who were followed-up our tertiary referral center. Methods: Database Clinic was screened for...

Background: Positron emission tomography (PET/CT) has gained importance in the diagnosis and assessment of large vessel vasculitis (LVV) recently. Objectives: We aimed to investigate diagnostic clinical significance PET/CT findings giant cell arteritis (GCA). Methods: Data patients who underwent involvement had at least 6 months follow-up with a GCA were retrospectively evaluated. images assessed by an experienced nuclear medicine specialist, regions interest drawn for major vascular...

Background: Psoriatic arthritis (PsA) is a heterogeneous disease and GRAPPA have proposed Minimal activity (MDA) as composite outcome measure has been validated in PsA. Objectives: In this study, we aimed to evaluate the characteristics, MDA frequencies, first biological modifying antirheumatic drugs (b-DMARD) continuation rate associated factors our PsA cohort. Methods: patients who fulfilled CASPAR classification criteria had at least six months of follow-up data were evaluated...