A5040501773- Occupational and environmental lung diseases
- Cancer Research and Treatments
- Liver physiology and pathology
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Neuropeptides and Animal Physiology
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Graphene and Nanomaterials Applications
- Pancreatic function and diabetes
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Macrophage Migration Inhibitory Factor
- Ubiquitin and proteasome pathways
- Tissue Engineering and Regenerative Medicine
- Advanced Glycation End Products research
- Fibroblast Growth Factor Research
- PI3K/AKT/mTOR signaling in cancer
- Polyomavirus and related diseases
- Protein Hydrolysis and Bioactive Peptides
- Cancer Mechanisms and Therapy
- ATP Synthase and ATPases Research
- HER2/EGFR in Cancer Research
- Protein Kinase Regulation and GTPase Signaling
Cancer Center of Hawaii
2014-2024
University of Hawaii System
2014-2024
University of Hawaiʻi at Mānoa
2014-2024
University of Hawaii Cancer Center
2014-2024
Mesothelioma Applied Research Foundation
2018
Eisai (United Kingdom)
2018
Hyogo Medical University
2018
Takeda (Japan)
2018
University of Hawaii–West Oahu
2015
University of Turin
1989-2013
Hepatocyte Growth Factor (HGF, also known as Scatter Factor) is a powerful mitogen or motility factor in different cells, acting through the tyrosine kinase receptor encoded by MET protooncogene. Endothelial cells express gene and expose at cell surface mature protein (p190MET) made of 50 kD (alpha) subunit disulfide linked to 145-kD (beta) subunit. HGF binding endothelial identifies two sites with affinities. The higher affinity site (Kd = 0.35 nM) corresponds p190MET receptor....
BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms. To answer the question if different germline may predispose to single syndrome wide phenotypic range or distinct syndromes, we investigated presence in two unrelated families (L W) mesothelioma. Suspicious cutaneous lesions were clinically pathologically...
Abstract Human malignant mesothelioma is an aggressive and highly lethal cancer that believed to be caused by chronic exposure asbestos erionite. Prognosis for this generally poor because of late-stage diagnosis resistance current conventional therapies. The damage-associated molecular pattern protein HMGB1 has been implicated previously in transformation mesothelial cells. Here we show establishes autocrine circuit cells influences their proliferation survival. Malignant strongly expressed...
Exposure to erionite, an asbestos-like mineral, causes unprecedented rates of malignant mesothelioma (MM) mortality in some Turkish villages. Erionite deposits are present at least 12 US states. We investigated whether increased urban development has led erionite exposure the United States and after preliminary exploration, focused our studies on Dunn County, North Dakota (ND). In ND, we discovered that over past three decades, more than 300 miles roads were surfaced with erionite-containing...
MicroRNAs (miRNAs) post-transcriptionally regulate the expression of target genes, and may behave as oncogenes or tumor suppressors. Human malignant mesothelioma is an asbestos-related cancer, with poor prognosis low median survival. Here we report, for first time, a cross-evaluation miRNA in (MPP-89, REN) human mesothelial cells (HMC-telomerase reverse transcriptase). Microarray profiling, confirmed by real-time quantitative RT-PCR, revealed differential miRNAs between cells. In addition,...
When grown as three-dimensional structures, tumor cells can acquire an additional multicellular resistance to apoptosis that may mimic the chemoresistance found in solid tumors. We developed a spheroid model of malignant mesothelioma investigate molecular mechanisms acquired apoptotic resistance. cell lines, when spheroids, variety stimuli, including combinations necrosis factor-related apoptosis-inducing ligand (TRAIL), ribotoxic stressors, histone deacetylase, and proteasome inhibitors,...
We used a custom-made comparative genomic hybridization array (aCGH; average probe interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy number loss throughout the 3p21 region (10.7 Mb) that harbors 251 genes, including BRCA1 (breast cancer 1)-associated protein 1 (BAP1), most commonly mutated gene in MM. identified frequent minute biallelic deletions (<3 kb) 46 of genes: four were cancer-associated SETD2 (SET domain-containing 2) (7 33), BAP1 (8 PBRM1...
We hypothesized that four criteria could help identify malignant mesotheliomas (MMs) most likely linked to germline mutations of BAP1 or other genes: family history MM, BAP1-associated cancers, multiple malignancies; age younger than 50 years.
Carriers of heterozygous germline BAP1 mutations (BAP1+/-) develop cancer. We studied plasma from 16 BAP1+/- individuals 2 families carrying different and 30 wild-type (BAP1WT) controls these same families. Plasma samples were analyzed by liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS), ultra-performance triple quadrupole (UPLC-TQ-MS), gas (GC-TOF-MS). found a clear separation in the metabolic profile between BAP1WT individuals. confirmed specificity data vitro using 12...
Malignant mesothelioma is strongly associated with asbestos exposure. Among fibers, crocidolite considered the most and chrysotile least oncogenic. Chrysotile accounts for more than 90% of used worldwide, but its capacity to induce malignant still debated. We found that exposures have similar effects on human mesothelial cells. Morphological molecular alterations suggestive epithelial-mesenchymal transition, such as E-cadherin down-regulation β-catenin phosphorylation followed by nuclear...
Significance Millions of people have been exposed to asbestos and are at increased risk developing mesothelioma, an aggressive malignancy resistant current therapies. Here, we elucidate critical steps in carcinogenesis: induces the release high mobility group box 1 that triggers autophagy. Autophagy activation constitutes a key biological process allows some mesothelial cells survive cytotoxicity consequently increases fraction DNA-damaged human susceptible malignant transformation. We found...