A5088313281- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- interferon and immune responses
- Neurofibromatosis and Schwannoma Cases
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- TGF-β signaling in diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Hematomas and Complications
- Dermatologic Treatments and Research
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Brain Metastases and Treatment
- Global Maternal and Child Health
- Ear and Head Tumors
- Bone Metabolism and Diseases
- Parasites and Host Interactions
- Acne and Rosacea Treatments and Effects
- Intracranial Aneurysms: Treatment and Complications
- Parasite Biology and Host Interactions
- RNA Research and Splicing
Capital Medical University
2015-2025
Beijing Tian Tan Hospital
2015-2025
National Clinical Research Center for Digestive Diseases
2014-2022
Chinese Institute for Brain Research
2016-2019
Beijing Institute of Neurosurgery
2016
OBJECTIVE Skull base chordoma is relatively rare, and a limited number of reports have been published regarding its clinical features. Moreover, the factors associated with extent resection, as well value marginal resection for long-term survival, are still in question this disease. The objective study was to investigate these by evaluating their features surgical outcomes. METHODS A retrospective analysis 238 patients skull chordomas, who met inclusion criteria, performed. This summarized...
OBJECTIVE The natural history of cerebral cavernous malformations (CMs) has been widely studied, but the clinical course untreated thalamic CMs is largely unknown. Hemorrhage these lesions can be devastating. authors undertook this study to obtain a prospective hemorrhage rate and provide better understanding prognosis CMs. METHODS This longitudinal cohort included patients with who were diagnosed between 2000 2015. Clinical data recorded, radiological studies extensively reviewed, follow-up...
Chordoma is a rare malignant bone tumor exhibiting poor survival and prognosis. Hence, it crucial to develop convenient effective prognostic classification method for the rehabilitation management of patients with chordoma. In this study, we combined DNA methylation profiles magnetic resonance imaging (MRI) images generate radiogenomic signature assess its effectiveness prognosis in skull base from chordoma tissue samples 40 were factorized into eight signatures. Among them, Signature 4 was...
Abstract Skull base chordoma is a rare and fatal disease, recurrence of which inevitable, albeit variable. We aimed to investigate the clinicopathologic features disease progression, identify prognostic factors, construct nomogram for predicting progression in individual patients. Data 229 patients with skull treated by one institution between 2005 2014 were retrieved grouped as primary recurrent. Kaplan–Meier survival was estimated, taking competing risks into account. Multivariable Cox...
<h3>BACKGROUND AND PURPOSE:</h3> Skull base chordoma has been widely studied in recent years, however, imaging characteristics of this tumor have not well elaborated. The purpose study was to establish an MR grading system for skull chordoma. <h3>MATERIALS METHODS:</h3> In study, 156 patients with chordomas were retrospectively assessed. Tumor-to-pons signal intensity ratios calculated from pretreatment images R<sub>T1</sub> (ratio pons T1 FLAIR sequence), R<sub>T2</sub> T2 sequence) and...
Patients with skull base chordomas have a poor prognosis, and the role of protein expression brachyury in remains to be fully elucidated. The present study used immunohistochemistry analyze 57 cases chordoma, analyzed clinical data patients. results demonstrated that was negative 8.8% (5/57) cases. weak/positive, positive strong/positive rates were 5.3% (3/57), 21.1% (12/57) 64.9% (37/57), respectively. association between recurrence not statistically significant. Kaplan‑Meier analysis...
Although a bone tumor, significant differences in the extent of invasion exist skull base chordoma, which directly affect surgical resection, and have an impact on its prognosis. However, underlying mechanism phenomenon is not clearly understood. Therefore, we used iTRAQ-based quantitative proteomics strategy to identify potential molecular signatures, find predictive markers discrepancy clivus chordoma. According invasive classification criteria, 35 specimens chordoma were calssified be...
Abstract Chordoma is a rare bone malignancy with high rate of local recurrence and distant metastasis. Although DEP domain-containing protein 1B (DEPDC1B) implicated in variety malignancies, its relationship chordoma unclear. In this study, the biological role molecular mechanism DEPDC1B were explored. The function cells was clarified through loss-of-function assays vitro vivo. Furthermore, recognized by RNA sequencing Co-Immunoprecipitation (Co-IP) assay. malignant behaviors knockdown...
A recent chordoma cancer genotyping study reveals that the rs2305089, a single nucleotide polymorphism (SNP) located in brachyury gene and key development of notochord, is significantly associated with risk. The believed to be one genes involved pathogenesis chordoma, rare primary bone tumor originating along spinal column or at base skull. association between Gly177Asp risk skull Chinese populations currently unknown. We investigated genotype distribution this SNP 65 skull-base cases 120...
The roles of T (brachyury) isoforms in chordomas remain unclear. This study aimed to investigate the different and mechanisms them chordomas.The expression mRNAs 57 was assessed, a prognosis analysis conducted. Cell apoptosis, proliferation cell cycle assays were performed after specific isoform mRNA knockdown. Whole-transcriptome sequencing, Gene Set Enrichment Analysis, Ontology analysis, Kyoto Encyclopedia Genes Genomes competing endogenous RNA (ceRNA) conducted.As revealed this study,...
Meningiomas, as the most common primary tumor of central nervous system, are known to harbor genomic aberrations that associate with clinical phenotypes. Here we performed genome-wide genotyping for cranial meningiomas in 383 Chinese patients and identified 9,821 copy-number variations (CNVs). Particularly, diverse features had distinct CNV profiles. burdens were greater high-grade (WHO grade II III) samples, recurrent lesions, large tumors (diameter >4.3 cm), those collected from male...
Cerebral schistosomiasis is a rare but severe manifestation of
The object of this study was to clarify the expression characteristics and prognostic value survivin in skull base chordomas.