David O'Neill

ORCID: 0000-0002-1609-7666
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About
Contact & Profiles
Research Areas
  • Ultrasound and Hyperthermia Applications
  • Thermoelastic and Magnetoelastic Phenomena
  • Viral Infections and Immunology Research
  • Atomic and Subatomic Physics Research
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Reflective Practices in Education
  • Biomedical and Engineering Education
  • Engineering Education and Curriculum Development
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Experimental Learning in Engineering
  • Advanced MRI Techniques and Applications
  • Innovations in Medical Education
  • Trauma Management and Diagnosis
  • Cardiac Arrest and Resuscitation
  • Traumatic Ocular and Foreign Body Injuries
  • Higher Education Learning Practices
  • Liver Disease Diagnosis and Treatment
  • Respiratory Support and Mechanisms
  • Advanced Thermodynamics and Statistical Mechanics
  • Infrared Thermography in Medicine
  • Food Allergy and Anaphylaxis Research
  • Higher Education and Employability
  • Brain Metastases and Treatment
  • Hemoglobin structure and function
  • Ultrasound Imaging and Elastography

Northwestern University
2020-2025

McCormick (United States)
2025

Northwestern University
2024

Emory University
2020-2024

Georgia Institute of Technology
2020-2024

North Carolina State University
2024

Manchester College
2024

New College
2024

St. Mary's University, Texas
2024

American Society For Engineering Education
2020

Objectives Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Iron deficiency, with or without anaemia, associated other chronic conditions, such as congestive heart failure, where it predicts worse outcome. However, the prevalence iron deficiency in COPD unknown. This observational study aimed to determine associations differences clinical phenotype. Setting University hospital outpatient clinic. Participants 113 adult patients (65% male) diagnosed...

10.1136/bmjopen-2015-007911 article EN cc-by BMJ Open 2015-07-01

The treatment of cancerous tumours in the liver remains clinically challenging, despite wide range possibilities, including radio-frequency ablation (RFA), high-intensity focused ultrasound and resection, which are currently available. Each has its own advantages disadvantages. For non- or minimally invasive modalities, such as RFA, considered here, it is difficult to monitor vivo . This particularly problematic liver, where large blood vessels act heat sinks, dissipating delivered shrinking...

10.1098/rsta.2011.0240 article EN Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences 2011-10-03

There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O2, CO2, and water vapor within the airway every 10 ms. The analyzer is integrated a novel respiratory flow meter that an order magnitude more precise than other meters. Such precision, coupled with accurate alignment gas concentrations flow, makes possible determination O2 by direct integration over time product...

10.1126/sciadv.1600560 article EN cc-by-nc Science Advances 2016-08-05

Inhomogeneity in the lung impairs gas exchange and can be an early marker of disease. We hypothesized that highly precise measurements contain sufficient information to quantify many aspects inhomogeneity noninvasively. Our aim was explore whether one parameterization could both fit such data provide reliable parameter estimates. A mathematical model inhomogeneous developed, containing parameters for compliance, vascular conductance, dead space, all relative volume. Inputs were respiratory...

10.1152/japplphysiol.00745.2017 article EN Journal of Applied Physiology 2017-10-26

Existing techniques for the non-invasive in vivo study of dynamic changes skeletal muscle metabolism are subject to several limitations, example, poor signal-to-noise ratios which result long scan times and low temporal resolution. Hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy (HP-MRS) allows real-time visualization metabolic processes has been used extensively cardiac metabolism, but not resolved oxidative phosphorylation contracting muscle. Combining HP-MRS with an...

10.1002/nbm.70020 article EN cc-by NMR in Biomedicine 2025-04-02

10.1016/j.ijheatmasstransfer.2010.12.019 article EN International Journal of Heat and Mass Transfer 2011-01-24

A number of mathematical models have been produced that, given the Pco2 and Po2 blood, will calculate total concentrations for CO2 O2 in blood. However, all these contain at least some empirical features, thus do not represent underlying physicochemical processes an entirely mechanistic manner. The aim this study was to develop a model carriage by blood determine whether our understanding physical chemistry major chemical components together with their interactions is sufficiently strong...

10.1152/japplphysiol.00318.2016 article EN Journal of Applied Physiology 2016-11-24

Abstract Providing students with detailed, descriptive feedback and having them reflect on what they have learned can foster self-directed learning (Ambrose, 2013); a critical ability for future engineers whom need to be able translate their skills knowledge novel situations (Bary & Rees, 2016). Standards-based grading (SBG) has been slowly emerging in the engineering education field as way provide how well are meeting course objectives (Carberry, et. al., This approach contrasts traditional...

10.18260/1-2--38079 article EN mit 2020 ASEE Virtual Annual Conference Content Access Proceedings 2024-02-20

Abstract Introduction: Reflective practices have been used in conjunction with many evidence-based strategies, including standards-based grading [1] to tailor student learning and efforts are known increase awareness about [2]. This study investigated the implementation of different reflective a laboratory course that uses grading. We hypothesized reflecting while completing deliverables addition post-submission reflection would enhance as measured by system when compared only...

10.18260/1-2--40716 article EN 2024-02-06

It has been suggested that Coxsackie B virus infections may play a part in causing or triggering myocardial infarction. This study was designed to compare the incidence of such Coronary Care Unit patients and normal controls. The choice suitable criterion for diagnosis infection is discussed fully. Two hundred fifty admissions 100 control subjects had serum sample tested by microneutralisation antibodies. among 130 diagnosed as acute infarction 5% compared with 4% group. In subgroup...

10.1136/jcp.36.6.658 article EN Journal of Clinical Pathology 1983-06-01

Summary Pneumopericardium and pneumomediastinum have been described as complications of endotracheal intubation assisted ventilation in neonates children. Here the occurrence these an adult is possible mechanism discussed.

10.1136/pgmj.55.642.273 article EN Postgraduate Medical Journal 1979-04-01

Identification of salvageable brain tissue is a major challenge when planning the treatment ischaemic stroke. As standard technique used in this context, perfusion-diffusion mismatch, has not shown total accuracy, there an ongoing search for new imaging protocols that could better identify region at risk and physiological models could, on one hand, incorporate imaged parameters predict evolution condition individual, and, other future biomarkers thus suggest directions design protocols....

10.1098/rsfs.2012.0079 article EN Interface Focus 2013-02-21

Ablation techniques have become a widespread choice for the treatment of cancerous tumors which surgical resection poor prognosis. The minimally invasive nature and high success rate when performed by experienced clinicians mean that ablation is likely to remain core technique. However, can drop off dramatically less-experienced operators are involved, it particularly difficult kill all tumor only tumor, given dynamic processes lead cell death. Mathematical modeling response has long...

10.1615/critrevbiomedeng.v38.i1.30 article EN Critical Reviews in Biomedical Engineering 2010-01-01

We compute the Gaseous Dynamical Friction (GDF) force experienced by massive perturbers on elliptical Keplerian orbits. In this paper, we investigate density wake morphology, dynamical friction force, and secular orbital evolution for single as well equal mass binaries embedded in an homogenous, static background flow. all cases, rate-of-change semi-major axis is found to be negative (as expected), whereas eccentricity strictly-subsonic trajectories positive strictly-supersonic trajectories....

10.48550/arxiv.2401.16166 preprint EN arXiv (Cornell University) 2024-01-29

Abstract Introduction: This work-in-progress study assesses the impact of reflective practices, including peer review, on written assignments in a sophomore-level, biomedical engineering laboratory course. The course serves as an introduction to experimentation and covers statistical design experiments well how quantify quality experimental measurement data. Topics include problem-solving skills, scientific writing, hypothesis generation, amongst other research-related topics. Course...

10.18260/1-2--44182 article EN 2024-02-07

Nineteen patients with hay fever symptoms received nine weekly injections of pyridine-extracted alum-precipitated grass pollen vaccine (Alavac P). The results were compared agroup twenty who a three injection series glutaraldehyde-modified pollen-tyrosine (Pollinex). In both groups 65% had subjective improvement in their and no significant difference symptom scores was obtained throughout the season. Pollinex group lower incidence systemic side effects recorded.

10.1111/j.1365-2222.1977.tb01441.x article EN Clinical & Experimental Allergy 1977-03-01

Data below 1 mm voxel size is getting more and common in the clinical practice but it still hard to obtain a consistent collection of such datasets for medical image processing research. With this paper we provide large Contrast Enhanced (CE) Computed Tomography (CT) data from porcine animal experiments describe their acquisition procedure peculiarities. We have acquired three CE-CT phases at highest available scanner resolution 57 livers during induced respiratory arrest. These capture...

10.1109/isbi.2014.6867814 article EN 2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI) 2014-04-01

A model is presented that an alternative approach to the bio-heat equation for use in radio frequency heating of liver. The comprises both a tissue subvolume and blood subvolume. Separate equations are determined each subvolume, but with additional term exchanging heat between them, thus creating coupled system. derivation two differential outlined sample simulations demonstrate importance considering subvolumes separately, even when small fraction

10.1109/iembs.2009.5332651 article EN Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2009-09-01

Summary In a prospective study we identified group of 12 patients diagnosed as having acute myocardial infarction but with electrocardiographic features non-transmural and serological evidence recent Coxsackie B infection favouring the possibility myocarditis. The included 9 females 3 males, aged from 38–60 y. Coronary arteriography was carried out in 11 patients. Eight showed no significant (≥ 50%) coronary arterial obstruction. We suggest that artery disease did not contribute to clinical...

10.1136/pgmj.61.716.485 article EN Postgraduate Medical Journal 1985-06-01

Abstract Standards-based grading (SBG) involves the creation of course learning objectives (LO) and linking these to particular aspects assignments. Assignments are created such that students have opportunity show mastery in a objective multiple times over course. This approach aligns student assessment with intended outcomes, rather than traditional score-based grading. The technique has been implemented extensively K-12, but we just now beginning assess its use engineering higher...

10.18260/1-2--33591 article EN 2020-09-10

Thermal ablation of a tumour in the liver with Radio Frequency energy can be accomplished by using probe inserted into tissue under guidance medical imaging. The extent significantly affected heat loss due to high blood perfusion liver, especially when is located close large vessels. A mathematical model thus presented here investigate sinking effects vessels, combining 3D two-equation coupled bio-heat and 1D convective transport across vessel surface. simulation able recover experimentally...

10.1109/iembs.2011.6091693 article EN Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2011-08-01
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