A5062302604- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Single-cell and spatial transcriptomics
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Neural dynamics and brain function
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Advanced Neural Network Applications
- Biotin and Related Studies
- Neuropeptides and Animal Physiology
- Agricultural Productivity and Crop Improvement
- Botany and Plant Ecology Studies
- Signaling Pathways in Disease
- Cell Image Analysis Techniques
- Medical Imaging and Pathology Studies
- Autism Spectrum Disorder Research
- Macrophage Migration Inhibitory Factor
- Galectins and Cancer Biology
- RNA Research and Splicing
- Amino Acid Enzymes and Metabolism
- Plant Taxonomy and Phylogenetics
- Connective tissue disorders research
- Virology and Viral Diseases
Semmelweis University
2018-2024
University of Veterinary Medicine
2017
Schizophrenia is one of the most widespread and complex mental disorders. To characterize impact schizophrenia, we performed single-nucleus RNA sequencing (snRNA-seq) >220,000 neurons from dorsolateral prefrontal cortex patients with schizophrenia matched controls. In addition, >115,000 were analyzed topographically by immunohistochemistry. Compositional analysis snRNA-seq data revealed a reduction in abundance GABAergic concomitant increase principal neurons, pronounced for upper cortical...
Microglia, the brain's resident macrophages, shape neural development and are key neuroimmune hubs in pathological signatures of neurodevelopmental disorders. Despite importance microglia, their has not been carefully examined human brain, most our knowledge derives from rodents. We aimed to address this gap by establishing an extensive collection 97 post-mortem tissues order enable quantitative, sex-matched, detailed analysis microglia across lifespan. identify dynamics these cells...
Postnatal subventricular zone (SVZ) neural stem cells generate forebrain glia, namely astrocytes and oligodendrocytes. The cues necessary for this process are unclear, despite phase of brain development being pivotal in gliogenesis. Galectin-3 (Gal-3) is increased multiple pathologies thereby regulates astrocyte proliferation inflammation injury. To study the function Gal-3 gliogenesis, we carried out functional studies mouse. We overexpressed with electroporation using immunohistochemistry...
Abstract Neuroserpin is a serine‐protease inhibitor mainly expressed in the CNS and involved inhibition of proteolytic cascade. Animal models confirmed its neuroprotective role perinatal hypoxia‐ischaemia adult stroke. Although neuroserpin may be potential therapeutic target treatment aforementioned conditions, there still no information literature on distribution during human brain development. The present study provides detailed description changing spatiotemporal patterns focusing...
Schizophrenia (SCH) and autism spectrum disorder (ASD) share several common aetiological symptomatic features suggesting they may be included in a spectrum. For example, recent results suggest that excitatory/inhibitory imbalance is relevant the etiology of SCH ASD. Numerous studies have investigated this regions like ventromedial dorsolateral prefrontal cortex (DLPFC). However, relatively little known about neuroanatomical changes could reduce inhibition subcortical structures, such as...
Abstract Astrocytes, a type of glial cell, significantly influence neuronal function, with variations in morphology and density linked to neurological disorders. Traditional methods for their accurate detection measurement are laborious unsuited large-scale operations. We introduce dataset from human brain tissues stained aldehyde dehydrogenase 1 family member L1 (ALDH1L1) fibrillary acidic protein (GFAP). The digital whole slide images these were partitioned into 8730 patches 500 × pixels,...
ABSTRACT Schizophrenia is one of the most wide-spread mental brain disorders with complex and largely unknown etiology. To characterize impact schizophrenia at a cellular level, we performed single nucleus RNA sequencing >190,000 neurons from dorsolateral prefrontal cortex patients matched controls (7 vs 11, respectively). In addition, to correlate data cortical anatomy, >100,000 were analyzed topographically by immunohistochemistry in an extended cohort cases (10 10). Compositional...
The excitatory/inhibitory imbalance theory is widely accepted in the pathology of autism spectrum disorder. Recent results suggest its relevance aetiology schizophrenia as well (Jardri 2016, Yang 2017, Gao and Penzes 2015). In order to discover possibly altered neuronal composition numerous studies have been focussing mainly on different cortical regions such ventromedial prefrontal cortex dorsolateral cortex. particular, various interneuronal populations found altered.2 However, relatively...
Abstract d -Aspartate ( -Asp) and -serine -Ser) have been proposed to promote early-phase LTP in vitro enhance spatial memory vivo. Here, we investigated the behavioural effects of chronic consumption -Asp -Ser on learning mice together with expression NMDA receptors. We also studied alterations neurogenesis by morphometric analysis bromo-deoxyuridine incorporating doublecortin expressing cells hippocampus. Our results specify a time period (3–4 h post-training), within which animals exposed...
Abstract Schizophrenia (SCH) is a chronic and serious mental illness which puts an enormous burden on the individual, families, society. It well established that altered dopamine signaling excitatory‐inhibitory imbalance contributes to symptoms of schizophrenia. Recent neuroimaging histological studies suggest striatum key area involved in SCH, however, our knowledge how specific cell neuronal subtypes certain subcortical structures may be impaired incomplete. To this date, no detailed...
A növényt, amelyet 1994-ben Vaccinium oxycoccos L. néven közöltek a Siroki Nyírjes-tóról, e cikk első szerzője 1999-ben microcarpum (Turcz. ex Rupr.) Schmalh. fajként azonosította. határozás helyességét bizonyító morfometriai tulajdonságok gyűjtésére 2016. augusztus 24-én került sor siroki Nyírjes-tó tőzegmohalápján és szeptember 2-án 3-án beregi Báb-tava Nyíres-tó tőzegmohalápján. vizsgálatokhoz felhasználtuk Beregi-lápokon készített korábbi saját fényképfelvételeinket is. állomány...
Microglia, the brain’s resident macrophages, shape neural development and wiring, are key neuroimmune hubs in pathological signature of neurodevelopmental disorders. In human brain, microglial has not been carefully examined yet, most our knowledge derives from rodents. We established an unprecedented collection 97 post-mortem tissues enabling quantitative, sex-matched, detailed analysis microglia across lifespan. identify dynamics these cells telencephalon, describing novel waves density...