A5026593767- Neurogenesis and neuroplasticity mechanisms
- Galectins and Cancer Biology
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Wound Healing and Treatments
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Glycosylation and Glycoproteins Research
- Tissue Engineering and Regenerative Medicine
- Ion channel regulation and function
- Protein Tyrosine Phosphatases
- Memory and Neural Mechanisms
- Proteoglycans and glycosaminoglycans research
- Meta-analysis and systematic reviews
- Cellular Mechanics and Interactions
- Neonatal Respiratory Health Research
- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Signaling Pathways in Disease
Universidade Federal de São Paulo
2015-2021
University of Oxford
2015-2019
Intense activation of neurons triggers the appearance immediate expression genes, including c-Fos. This gene is related to various signal cascades involved in biochemical processes such as neuronal plasticity, cell growth and mitosis. Here we investigate pattern refractory period c-Fos rats monkey's brains after stimulation with pentylenetetrazol. Rats monkeys were sacrificed at times PTZ-induced seizure. show that already showed 0.5 h Yet, protein was longer than rats, also not uniform...
Cuprizone leads to demyelination of the corpus callosum (CC) and activates progenitor cells in adjacent subventricular zone (SVZ), a stem cell niche which contributes remyelination. The healthy SVZ contains semi-activated microglia constitutively expresses pro-inflammatory molecule galectin-3 (Gal-3) suggesting uniquely regulates inflammation. We studied inflammatory response cuprizone CC Gal-3 knockout mice using immunohistochemistry with vitro neurosphere assay. caused loss myelin basic...
Brain injuries such as trauma and stroke lead to glial scar formation by reactive astrocytes which produce secret axonal outgrowth inhibitors. Chondroitin sulfate proteoglycans (CSPG) constitute a well-known class of extracellular matrix molecules produced at the cause growth cone collapse. The CSPG glycosaminoglycan side chains composed chondroitin (CS) are responsible for its inhibitory activity on neurite dependent RhoA activation. Here, we hypothesize that also impairs neural stem cell...
Multiple sclerosis (MS) frequently starts near the lateral ventricles, which are lined by subventricular zone (SVZ) progenitor cells that can migrate to lesions and contribute repair. Because MS‐induced inflammation may decrease SVZ proliferation thus limit repair, we studied role of galectin‐3 (Gal‐3), a proinflammatory protein. Gal‐3 expression was increased in periventricular regions human MS post‐mortem brain samples also upregulated murine model, Theiler's encephalomyelitis virus (TMEV)...
Postnatal subventricular zone (SVZ) neural stem cells generate forebrain glia, namely astrocytes and oligodendrocytes. The cues necessary for this process are unclear, despite phase of brain development being pivotal in gliogenesis. Galectin-3 (Gal-3) is increased multiple pathologies thereby regulates astrocyte proliferation inflammation injury. To study the function Gal-3 gliogenesis, we carried out functional studies mouse. We overexpressed with electroporation using immunohistochemistry...
Abstract Transplanting stem cells into the central nervous system is a promising therapeutic strategy. However, preclinical trials of cell-based therapies are limited by poor local cell engraftment and survival. Here, we present polylactic acid (PLA) scaffold to support delivery mesenchymal (MSCs) in mouse model stroke. We isolated bone marrow MSCs from adult C57/Bl6 mice, cultured them on PLA polymeric rough microfibrous (PLA-PRM) scaffolds obtained rotary jet spinning, transplanted brains...
Abstract Traumatic brain injury is an important cause of mortality and morbidity all over the world. After initial there a cascade cellular molecular events that ultimately lead to cell death. Therapies aim not only counteract these mechanisms but also replenish lost population in order achieve better recovery. The adult mammal as plastic postnatal, it has at least two neurogenic regions maintains physiological functions brain; subgranular zone dentate gyrus hippocampus, which produces...