A5008262587- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- Gastrointestinal disorders and treatments
- Anorectal Disease Treatments and Outcomes
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism, Diabetes, and Cancer
- Seaweed-derived Bioactive Compounds
- Enhanced Recovery After Surgery
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
Kaohsiung Medical University Chung-Ho Memorial Hospital
2015-2025
Kaohsiung Medical University
2015-2025
Creative Commons
2023
Taiwan Nurses Association
2023
Primary Source
2023
ORCID
2019
Fooyin University
2011-2013
Background The recurrence of colorectal cancer (CRC) is frequent within the first year curative resection surgery and may be unavoidable. microRNAs have been suggested to play roles in carcinogenesis recurrence. We recently identified microRNA-29c (miRNA-29c) as a predictor early CRC. In present study, we further investigated functions serum level miRNA-29c relation Methods First confirmed overexpression non-early relapse subjects. Gain-of-function vitro studies were used evaluate effect on...
Colorectal cancer (CRC) is the third leading cause of mortality worldwide and associated with high recurrence mortality, despite recent advancements in therapeutic strategies. MicroRNA (miR) deregulation CRC development recurrence; therefore, miRs may be reliable biomarkers for detecting early relapse postoperatively. In this study ten candidates were identified using miR arrays: miR-7, miR-31, miR-93, miR-141, miR-195, miR-375, miR-429, miR-494, miR-650, let-7b. Substantial differences...
Background: The high prevalence of type 2 diabetes mellitus (DM) among patients with colorectal cancer (CRC) is becoming a serious public health concern worldwide. FOLFOX4 chemotherapy one the most widely used adjuvant therapies in stage III colon after surgical resection. However, resistance associated poor prognosis. prognostic impact blood sugar levels on oxaliplatin CRC an unexplored topic. Methods: In total, 157 were classified according to their fasting level (⩾126 or <126 mg/dl)....
Curative resection is typically recommended for treating gastrointestinal stromal tumors (GISTs). Exceptions are made locally advanced GISTs (LAGISTs) where radical may be impossible. First-line imatinib therapy can employed to treat harboring mutations in the tyrosine-protein kinase KIT (KIT) and platelet-derived growth factor receptor α (PDGFRα) genes reduce tumor size resectable levels minimize surgical risks. The present study investigated treatment outcomes of patients with LAGISTs...
Colorectal cancer (CRC) is the third most common worldwide. The incidence and mortality rates of CRC are significantly higher in Taiwan than other developed countries. Genes involved tumorigenesis differ depending on whether tumor occurs left or right side colon, genomic analysis a keystone study treatment subtypes. However, few studies have focused genetic landscape Taiwanese patients with CRC. This comprehensively analyzed genomes 141 through whole-exome sequencing. Significant differences...
Studies have demonstrated that metformin has antitumor effects in addition to therapeutic on hyperglycemia; however, few studies explored the of chemotherapy. Therefore, we hypothesized administration would enhance 5-fluorouracil and oxaliplatin (FuOx) inhibit growth colorectal cancer (CRC) cells vitro vivo. The results our experiments significantly increased FuOx with respect cell proliferation (p < 0.05), colony formation migration 0.01) induced cycle arrest G0/G1 phase HT29 S SW480 SW620...
The pTNM staging system is widely recognized as the most effective prognostic indicator for cancer. latest update of this introduced a new pathological (ypTNM) patients receiving neoadjuvant chemoradiotherapy (NACRT). However, whether value ypTNM rectal cancer similar to that remains unclear. This study was conducted compare and systems in terms their with nonmetastatic undergoing proctectomy.
Abstract Background Angiogenesis plays an important role in the progression of colorectal cancer (CRC). Studies have indicated vascular endothelial growth factor (VEGF) is predominant angiogenic factor. Cyclin D1 (CCND1) induces production VEGF and required for migration blood vessels. Our aim was to determine roles CCND1 overexpression CRC patients. Methods We analyzed clinicopathological features, expressions by immunohistochemical (IHC) staining 100 stage I–III patients (44 were...
BACKGROUND: To evaluate the efficacy and toxicities of regorafenib plus irinotecan, dose-escalated on basis uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping, in previously heavily treated metastatic colorectal cancer (mCRC) prognostic values EGFR expression, KRAS mutations, tumor sidedness. METHODS: Forty-one patients with mCRC disease progression after treatment fluoropyrimidines, oxaliplatin, anti-VEGF, anti-EGFR MoAbs were subjected to UGT1A1 genotyping received...
It has been reported that 20-25% of patients with colorectal cancer (CRC) have metastases at the time diagnosis. Liver and lung are most common metastatic sites. The aim present study was to investigate association KRAS NRAS mutations clinicopathological features prognosis initial liver-metastasis only (LiM-only) or lung-metastasis (LuM-only) CRC (mCRC). Overall, 166 LiM-only (n=124) LuM-only (n=42) were retrospectively analyzed from January 2014 December 2017. median follow-up 19.2 months...
This study investigated the roles of low-molecular-weight fucoidan (LMWF) in enhancing anti-cancer effects fluoropyrimidine-based chemotherapy. HCT116 and Caco-2 cells were treated with LMWF 5-FU. Cell viability, cell cycle, apoptosis, migration analyzed both types. Potential mechanisms underlying how enhances chemotherapy also explored. The viability was significantly reduced after treatment a LMWF-–5FU combination. In cells, enhanced suppressive 5-FU on through (1) induction cycle arrest S...
Patients with cancer use low-molecular-weight fucoidan (LMF) as a supplement to therapy. However, most studies of LMF are in vitro or conducted using animals. Concurrent chemoradiotherapy (CCRT) is the gold standard for locally advanced rectal (LARC). This study investigated quality life (QoL) and clinical outcomes patients LARC taking neoadjuvant CCRT. was double-blind, randomized, placebo-controlled study. The sample comprised 87 patients, whom 44 were included group 43 placebo group. We...
This study analyzed the oncological outcomes of robotic-assisted total mesorectal excision (TME) in patients with rectal cancer after neoadjuvant concurrent chemoradiotherapy (CCRT). We enrolled 109 consecutive stage II–III who underwent TME CCRT at one hospital between July 2013 and June 2018. All preoperative CCRT. Of them, 37 (33.9%) achieved a pathologic complete response, 29 (26.6%) experienced relapse, local recurrence 9 (8.3%) distant metastasis 20 (18.3%). R0 resection was performed...
Background. The safety and efficacy of gastrectomy for locally advanced gastric cancer (LAGC) following neoadjuvant therapy have gained increasing attention. In this article, we present our preliminary treatment results compare the surgical outcomes concurrent chemoradiotherapy (CCRT) with those chemotherapy in patients LAGC. Patients Methods. Sixty-three a diagnosis LAGC (clinical staging cT3N2+, cT4aN+, or cT4b) who had received at any period from January 2014 to December 2020 were...