A5007599416- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Chemical Synthesis and Analysis
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Aortic Disease and Treatment Approaches
- Antioxidant Activity and Oxidative Stress
- Endoplasmic Reticulum Stress and Disease
- Catalytic Cross-Coupling Reactions
- Iron Metabolism and Disorders
- Vitamin C and Antioxidants Research
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Synthetic Organic Chemistry Methods
- Sulfur-Based Synthesis Techniques
- Tendon Structure and Treatment
- Silk-based biomaterials and applications
- Retinoids in leukemia and cellular processes
- Sports injuries and prevention
- Multicomponent Synthesis of Heterocycles
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Catalytic C–H Functionalization Methods
- Periodontal Regeneration and Treatments
- Complement system in diseases
Donghua University
2024
Zhejiang University
2018-2024
Wuhan Textile University
2021-2023
Pharmaceutical Biotechnology (Czechia)
2018
Hangzhou Xixi hospital
2018
Zhengzhou Children's Hospital
2017
Soochow University
2014
First Affiliated Hospital of Soochow University
2014
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2011
Guangzhou University
2004
Abstract Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this. Here, we reformulate lipid nanoparticles (LNPs) through adjustments in material structures compositions systematically the pulmonary hepatic (respectively) distribution expression. A combinatorial library of degradable-core based ionizable cationic lipids is designed, following by optimisation...
The imbalance between endogenous and exogenous healing is the fundamental reason for poor tendon healing. In this study, a Janus patch was developed to promote inhibit healing, leading improved repair. upper layer of poly(dl-lactide-co-glycolide)/polycaprolactone (PLGA/PCL) nanomembrane (PMCP-NM) modified with poly(2-methylacryloxyethyl phosphocholine) (PMPC), which created lubricated antifouling surface, preventing cell invasion mechanical activation. lower PLGA/PCL fiber membrane loaded...
Multicomponent reactions (MCRs) are powerful tool for the construction of polyfunctional molecules in an operationally simple and atom-economic manner, discovery novel MCRs requests various building blocks. Herein, triazenyl alkynes were disclosed as versatile blocks a multicomponent reaction with carboxylic acids, aldehydes anilines to furnish β-amino amides achievement high diastereoselectivity structural diversity. In this process, bifunctional so that alkyne moiety acts C2 fragment...
Protein neddylation is catalyzed by a three-enzyme cascade, namely an E1 NEDD8-activating enzyme (NAE), one of two E2 NEDD8 conjugation enzymes and several E3 ligases. The physiological substrates are the family members cullin, scaffold component cullin RING ligases (CRLs). Currently, potent inhibitor, MLN4924, also known as pevonedistat, in clinical trials for anti-cancer therapy. Here we report discovery, through virtual screening structural modifications, small molecule compound HA-1141...
A cascade reaction involving Diels–Alder for modular synthesis of amino α-pyrones, indolines and anilines is reported.
Herein we report a redox cyclization of amides and sulfonamides with nitrous oxide (N2O) for the direct synthesis heterocycles. Various could undergo directed ortho metalation (DoM) by treatment BuLi, lithium intermediate be trapped N2O gas to achieve cyclization. serves as N-atom donor mediate intramolecular coupling species toward heterocycle formation free external oxidant. This protocol offers heterocycles features readily available starting materials, simple operation, broad substrate scope.
Abstract Multicomponent reactions (MCRs) are powerful tool for the construction of polyfunctional molecules in an operationally simple and atom‐economic manner, discovery novel MCRs requests various building blocks. Herein, triazenyl alkynes were disclosed as versatile blocks a multicomponent reaction with carboxylic acids, aldehydes anilines to furnish β‐amino amides achievement high diastereoselectivity structural diversity. In this process, bifunctional so that alkyne moiety acts C2...
To comprehensively analyze the clinical characteristics, treatment strategies and outcome of patients with thrombotic thrombocytopenic purpura (TTP).A retrospective survey 51 TTP confirmed in our database. Relevant statistical analyzes were performed by GraphPad Prism 5 software.51 cases acquired identified as idiopathic TTP. In study, only 18 (35.29%) had typical pentalogy TTP, where thrombocytopenia (100.00%), microangiopathic hemolytic anemia (92.16%) neurologic abnormalities (88.24%)...
Abstract Polylactic acid (PLA) and silk fibroin (SF) have been widely used in biomedical applications because of their excellent biocompatibility degradability. In this study, PLA SF were as raw materials to prepare hollow fibers with a skin‐core structure by wet spinning technology. Scanning electron microscopy observations revealed that the became increasingly uniform increasing mass fraction. Tensile test results showed increase content, elastic modulus decreased tensile properties...
The heart valve is crucial for the human body, which directly affects efficiency of blood transport and normal functioning all organs. Generally, decellularization one method tissue-engineered (TEHV), can deteriorate mechanical properties eliminate allograft immunogenicity. In this study, removable polyvinyl alcohol (PVA) used to encapsulate decellularized porcine valves (DHVs) as a dynamic template improve processability DHVs, such suturing. Mechanical tests show that strength elastic...
目的 分析小儿急性早幼粒细胞白血病（APL）采用三氧化二砷结合全反式维甲酸治疗的效果。 方法 选取本院收治的APL患儿84例，随机分为A组与B组，每组42例。A组予以全反式维甲酸口服，B组在A组基础上加用三氧化二砷治疗，比较两组的完全缓解（CR）率、白细胞峰值、达CR时间、复发率、无病生存率以及不良反应。 结果 ①CR率：A组为64.29%，B组为85.71%，两组对比差异有统计学意义（P 0.05）。 结论 APL患儿接受全反式维甲酸+三氧化二砷治疗后，复发率降低，CR率较高，值得临床推广。
Enhancing the mechanical properties and cytocompatibility of decellularized heart valves is key to promote application biological valves. In order further improve properties, electrospinning non-woven processing methods are combined prepare polylactic acid (PLA)/decellularized valve nanofiber-reinforced sandwich structure electrospun scaffold. The effect time on performance investigated from aspects morphology, softness, biocompatibility valve. Results tests show that compared with pure...