A5004952127- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Signaling Pathways in Disease
- Nerve injury and regeneration
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Protein Kinase Regulation and GTPase Signaling
- Calpain Protease Function and Regulation
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Molecular Biology Techniques and Applications
- Retinoids in leukemia and cellular processes
- Silk-based biomaterials and applications
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Cell Adhesion Molecules Research
- Prostate Cancer Treatment and Research
- RNA and protein synthesis mechanisms
- Neuropeptides and Animal Physiology
Institute of Crystallography
2021-2022
Consorzio Interuniversitario per le Biotecnologie
2006-2021
The MAGE gene family is characterized by a conserved domain (MAGE Homology Domain). A subset of highly homologous genes (group A; MAGE-A) belong to the chromosome X-clustered cancer/testis antigens. MAGE-A are normally expressed in human germ line and overexpressed various tumor types; however, their biological function largely unknown. Here we present evidence indicating that MageA2 protein, belonging subfamily, confers wild-type-p53-sensitive resistance etoposide (ET) inducing novel p53...
The regulation of cell migration is a highly complex process that often compromised when cancer cells become metastatic. microtubule cytoskeleton necessary for migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting remains unclear. Microtubule plus-end binding (+TIPs) are emerging as important players in many cellular functions, including migration. Here we identify +TIP, GTSE1, promotes GTSE1 accumulates at growing plus ends through...
// Debora Stelitano 1 , Yamila Peche Leticia Emiliano Dalla Martin Monte 2 Silvano Piazza 1, 3 and Claudio Schneider 4 Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie (L.N.CIB), Trieste, Italy de Oncología Molecular, Departamento Química Biológica IQUIBICEN-UBA/CONICET, Universidad Buenos Aires, Argentina Bioinformatics Core facility, Centre for Integrative Biology, University of Trento (CIBIO), Trento, Dipartimento di Scienze Biomediche e...
Calpains regulate a wide spectrum of biological functions, including migration, adhesion, apoptosis, secretion, and autophagy, through the modulating cleavage specific substrates. Ubiquitous microcalpain (μ-calpain) millicalpain (m-calpain) are heterodimers composed catalytic subunits encoded, respectively, by CAPN1 CAPN2 regulatory subunit encoded CAPNS1. Here we show that calpain is required for stability deubiquitinating enzyme USP1 in several cell lines. modulates DNA replication...
MAGE-A (Melanoma Antigen Genes-A) are tumor-associated proteins with expression in a broad spectrum of human tumors and normal germ cells. gene function being increasingly investigated to better understand the mechanisms by which MAGE collaborate tumorigenesis whether their detection could be useful for disease prognosis purposes. Alterations epigenetic involved silencing cause frequent co-expression tumor Here, we have analyzed effect our results suggest that MageA6 can potentiate androgen...
The neurotrophins, i.e., Nerve Growth Factor (NGF), Brain-Derived Neurotrophic (BDNF), Neurotrophin 3 (NT3) and 4 (NT4), are known to play a range of crucial functions in the developing adult peripheral central nervous systems. Initially synthesized as precursors, proneurotrophins (proNTs), that cleaved release C-terminal mature forms, they act through two types receptors, specific Trk receptors (Tropomyosin-related kinases) pan-neurotrophin receptor p75NTR, initiate survival differentiative...
Chimaerins are high affinity receptors for phorbol esters and diacylglycerol (DAG), unrelated to the protein kinase C isozymes. These have deep implications in tumour biology since they regulate activity of Rac1, a small GTP-binding Ras superfamily. It has been demonstrated that chimaerins GTPase activating (GAP) activity, leading acceleration GTP hydrolysis from Rac1 therefore facilitating transition its inactive state. Rac regulates various cellular events, including gene transcription,...
The human genetic variant BDNF (V66M) represents the first example of neurotrophin family member that has been linked to psychiatric disorders. In order elucidate structural differences account for effects in cognitive function, this hproBDNF polymorph was expressed, refolded, purified, and compared directly WT time their 3D structures by DSF, limited proteolysis, FT-IR, SAXS measurements solution. Our complementary studies revealed a deep impact V66M polymorphism on conformations Although...